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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Alzheimer's disease: molecular understanding predictsamyloid-based therapeutics 显示文摘 | Selkoe DJ Schenk D | 2003 | Annu Rev Pharmacol Toxicol2003，43，： | 1 |
| 3 | The amyloid hypothesis of Alzheimer's dis- ease: progress and problems on the road to therapeutics显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，5580： | 1 |
| 4 | Alzheimer's disease : genes, proteins, and therapy 显示文摘 | Selkoe D J | 2001 | Physiol Rev2001，81，2： | 1 |
| 5 | The amyloid hypothesis of Alzheimer's disease:progress and problems on the road to therapeutics显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，5800： | 1 |
| 6 | Soluble protein oligomers in neurode- generation: lessons from the Alzheimer's amyloid beta - peptide 显示文摘 | HAASS C SELKOE D J | 2007 | Nat Rev Mol Cell Biol2007，8，2： | 1 |
| 7 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics 显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，： | 1 |
| 8 | Soluble oligomers of the amyloid beta- protein impair synaptic plasticity and behavior显示文摘 | Selkoe D J | 2008 | Behavioural Brain Research2008，192，： | 1 |
| 9 | Alzheimer's disease:a central role for amyloid显示文摘 | Selkoe D J | 1994 | J Neuropath Exp Neurol1994，53，5： | 1 |
| 10 | Alzheimer′s disease:molecular understanding predicts amyloid-based therapeutics显示文摘 | Selkoe DJ Schenk D | | 0，，06： | 1 |
| 11 | The amyloid hypothesis of Alzheimer's disease: progTess and problems on the road to therapeutics 显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，： | 1 |
| 12 | Alzheimer's disease: genes, proteins,and therapy显示文摘 | Selkoe D J | 2001 | Physiol Rev2001，81，2： | 1 |
| 13 | The amyloid hypothesis of Alzheimer' disease:Progress and problems on the road to therapeutics显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，5580： | 1 |
| 14 | The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，： | 1 |
| 15 | Translating cell biology into therapeutic advances in Alzheimer's disease显示文摘 | Selkoe D J | 1999 | Nature1999，399，6738： | 1 |
| 16 | Alzheimer's disease: genes, proteins, and therapy 显示文摘 | Selkoe D J | 2001 | Physiol Rev2001，81，2： | 1 |
| 17 | The amyloid hypothesis ofAlzheimer's disease: progress and problems on theroad to therapeutics 显示文摘 | Hardy J Selkoe D J | 2002 | Science2002，297，5580： | 1 |
| 18 | Notch and presenilin:regulated intramembrane proteolysis links development and degeneration显示文摘 | Selkoe D Kopan R | 2003 | Aunu Rev Neurosci2003，26，： | 1 |
| 19 | Alzheimer's disease is a synaptic failure显示文摘 | Selkoe D J | 2002 | Science2002，298，： | 1 |
| 20 | Cell biology of the amyloid geta-protein precursor and the mechanism of Alzheimer's disease显示文摘 | Selkoe D J | 1994 | Annu Rev Cell Biol1994，10，： | 1 |
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