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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment显示文摘 | Visser PJ Scheltens P Verhey FRJ | 1999 | J Neurol1999，246，6： | 1 |
| 3 | Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment显示文摘 | Visser PJ Verhey FRJ Hofman PAM | 2002 | J Neurol Neurosurg Psychiatry2002，72，4： | 1 |
| 4 | Morbidity related to defunctioning ileostomy closure after ileal pouch-anal anastomosis and low colonic anastomosis显示文摘 | van Westreenen HL Visser A Tanis PJ Bemelman WA | 2012 | Int J Colorectal Dis2012，27，1： | 1 |
| 5 | Interobserver agreement for the assessment of handicap in stroke patients显示文摘 | van Swieten JC Koudstaal PJ Visser MC | 1988 | Stroke1988，19，： | 1 |
| 6 | Interobserver agreement for the assessment of handicap in stroke patients显示文摘 | Van Swieten JC Koudstaal PJ Visser MC | 1988 | Stroke1988，，19： | 1 |
| 7 | Preclinical Alzheimer's disease and its outcome:a longitudinal cohort study显示文摘 | Vos SJ Xiong C Visser PJ | 2013 | Lancet Neurol2013，12，10： | 1 |
| 8 | In vitro osteoclast generation from different bone marrow fractions,including a highly enriched haematopoietic stem cell population显示文摘 | Scheven BA Visser JW Nijweide PJ | 1986 | Nature1986，321，6065： | 1 |
| 9 | Relationship between genetic risk factors and markers for Alzheimer's disease pathology显示文摘 | Elias-Sonnenschein LS Bertram L Visser PJ | | 0，，04： | 1 |
| 10 | Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment显示文摘 | KORF ES WAHLUND LO VISSER PJ | 2004 | Neurology2004，63，1： | 1 |
| 11 | Interobserver agreement {or the assessment of handicap in stroke patients显示文摘 | Van Swieten JC Koudataal PJ Visser MC | 1988 | Stoke1988，19，5： | 1 |
| 12 | Interobserver agreement for the assessment of handicap in stroke patients显示文摘 | Van Swieten JC Koudstaal PJ Visser MC | 1988 | Stroke1988，19，5： | 1 |
| 13 | Medial temporallobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment 显示文摘 | Visser PJ Verhey FR Hofman PA | 2002 | J Neurol Neurosurg Psychiatry2002，72，4： | 1 |
| 14 | Interobserver agreement for the assessment of handicap in stroke patients 显示文摘 | van Swieten JC Koudstaal PJ Visser MC | 1988 | Stroke1988，19，5： | 1 |
| 15 | Tau and p-tau as CSF biomarkers in dementia: a meta-analysis 显示文摘 | VanHarten AC Kester MI Visser PJ | 2011 | Chem Lab Med2011，49，3： | 1 |
| 16 | Tumefactive multiple sclerosis lesions under fingolimod treatment显示文摘 | Visser F Wattjes MP Pouwels PJ | 2012 | Neurology2012，79，： | 1 |
| 17 | Interobserver agreement for the assessment of handicap in stroke patients显示文摘 | Koudstaal PJ Visser MC | 1988 | Stroke1988，19，： | 1 |
| 18 | Interobserver agreement for the assessment of handicap in stroke patients显示文摘 | van Swieten JC Koudstaal PJ Visser MC | 1988 | Stroke1988，19，： | 1 |
| 19 | Mlid cognitive impairment (MCI) in medical practice:A critical review of the coneeDt and new diagnostic procedure : Report of the MC1 working group of the europeanconsortium on Alzheimer' s disease 显示文摘 | Portet F Ousset PJ Visser PJ | 2006 | Neurol Neuro- surg Psychatry2006，77，6： | 1 |
| 20 | Interobserver agreement for the assessment ofhandicap in stroke patients显示文摘 | van Swieten JC Koudstaal PJ Visser MC | 1988 | Stroke1988，19，： | 1 |
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