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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Neural correlates of cognitive impairment in posterior cortical atrophy显示文摘 | Kas A de Souza LC Samri D | 2011 | Brain2011，134，： | 1 |
| 3 | Photodynamic thera- py with two different photosensitizers as a supplement to instru- mentation / irrigation procedures in promoting intracanal reduc- tion of Enterococcus faecalis 显示文摘 | Souza LC Brito PR de Oliveira JC | 2010 | J Endod2010，36，2： | 1 |
| 4 | Comparison of the effectiveness of three !tigation tech- niques in reducing intraeanal Enteroeoecu faeealis pop- ulations: An in vitro study显示文摘 | Brito PR Souza LC Machado de Oliv!ia JC | 2009 | J Endod2009，35，10： | 1 |
| 5 | Nutritional as- sessment in hepatic cirrhosis ; clinical, anthropomctric, bi- ochemical and hematological parameters 显示文摘 | Vieira PM De -Souza DA Oliveira LC | 2013 | Nutr Hosp2013，28，5： | 1 |
| 6 | Susceptibility- weighted imaging for the evaluation of patients with familial cerebral cavernous malformations: a comparison with t2-weighted fast spin-echo and gradient-echo sequences显示文摘 | de Souza JM Domingues RC Cruz LC Jr | 2008 | AJNR Am J Neuroradiol2008，29，： | 1 |
| 7 | Clinical investigations in primary care显示文摘 | de Souza LC Sarazin M Goetz C | | 0，，： | 1 |
| 8 | Susceptibility-weighted imaging for the evaluation of patients with familial cerebral cavernous malformations:a comparison with T2-weighted fast spin-echo and gra- dient-echo sequences 显示文摘 | De Souza JM Domingues RC Cruz LC | 2008 | AJNR Am J Neuroradiol2008，29，1： | 1 |
| 9 | Photodynamic therapy with two different photosensitizers as a supplement to instrumentation irrigation procedures in promoting canal reduction of Enterococcus faecalis显示文摘 | Souza LC Brito PR De Oliveira JC | | 0，，03： | 1 |
| 10 | Similar amyloid-β burden in posterior cortical atrophy and Alzheimer' s disease显示文摘 | de Souza LC Codier F Habert MO | | 0，，7： | 1 |
| 11 | Schistosomiasis mansoni:follow-up of control program based on parasitologic and serologic methods in a Brazilian community of low endemicity显示文摘 | BURLANDY-SOARES LC DE SOUZA DIAS LC KANAMURA HY et a1 | 2003 | Mem Inst Oswaldo Cruz2003，98，6： | 1 |
| 12 | Photodynamic therapy with two different photosensitizers as a supplement to instrumentation/irrigation procedures in promoting intertarsal reduction of Enterococcus faecalis显示文摘 | Souza LC Brito PR de Oliveira JC | | 0，，02： | 1 |
| 13 | Altered response of strain of Schistosoma mansoni to oxamniquine and praziquantel 显示文摘 | Bonesso-Sabadini PI de Souza Dias LC | 2002 | Mem Inst Oswaldo Cruz2002，97，3： | 1 |
| 14 | Photedynamic therapy with two different photosensitizers as a supplement to instrumentation/irrigation procedures in promoting intracoual reduction of Enterococcus faecalis显示文摘 | Souza LC Brito PR de Oliveira JC | 2010 | J Ended2010，36，2： | 1 |
| 15 | Neural correlates ofcognitive impairment in posterior cortical atrophy 显示文摘 | Kas A de Souza LC Samri D | 2011 | Brain2011，134，5： | 1 |
| 16 | Biological markers of Alzheimer's disease 显示文摘 | de Souza LC Sarazin M Teixeira-Janior AL | 2014 | Arq Neurepsiquiatr2014，72，3： | 1 |
| 17 | CSF tau markers are correlated with hippocampal volume in Alzheimer's disease显示文摘 | De Souza LC Chupin M Lamari F | 2012 | Neurobiology of Aging2012，33，7： | 1 |
| 18 | Susceptibilityweighted imping for the evaluation of patients with familial cerebral cavernous malformations:a comparison with T2-weighted fast spin-echo and gradient-echo sequences显示文摘 | de Souza JM Domingues RC Cruz LC Jr | 2008 | AJNR Am J Neuroradiol2008，29，1： | 1 |
| 19 | WT1,WTX and CTNNB1 mutation analysis in 43 patients with sporadic Wilms'tumor显示文摘 | Cardoso LC De Souza KR De AH | 2013 | Oncol Rep2013，29，1： | 1 |
| 20 | Immunotherapy in alzheimers disease;do we have all the pieces of the puzzle?显示文摘 | Sarazin M Dorothee G de Souza LC | 2013 | Biol Psychiatry2013，74，5： | 1 |
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