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| 1 | Genetic polymorphism in pathogenesis of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a complex symptombased disorder without established biomarkers or putative pathophysiology.IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3mo according to ROMEⅢ:relief by defecation,onset associated with a change in stool frequency or onset with change in appearance or form of stool.Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms,as well as the therapeutic responses in treating IBS patients.This review gives new insights on how genetic determinations influence in clinical manifestations,treatment responses and potential biomarkers of IBS. | Cynthia KY Cheung Justin CY Wu | 2014 | World Journal of Gastroenterology2014，20，47： | 3 |
| 2 | Dietary Bacillus spp.enhanced growth and disease resistance of weaned pigs by modulating intestinal microbiota and systemic immunity显示文摘Background:Previous research has shown that dietary supplementation of Bacillus spp.probiotics exerts beneficial effects on animals’growth.However,limited studies have evaluated the efficacy of Bacillus spp.on weaned pigs and their effects on host gut health and microbiome,and systemic immunity using a disease challenge model.The objective of this experiment was to investigate the effects of two Bacillus spp.strains(Bacillus subtilis DSM 32540 and Bacillus pumilus DSM 32539)on growth performance,diarrhea,intestinal health,microbiome,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC).Results:Pigs in PRO1(Bacillus subtilis DSM 32540)had greater(P<0.05)body weight on d 7 and 14 PI,greater(P<0.05)ADG from d 0 to 7 and d 7 to 14 PI,compared with pigs in CON(Control).Pigs in PRO1 had milder(P<0.05)diarrhea on d 2 and 3 PI compared with pigs in CON.However,no differences were observed in growth performance and diarrhea score between PRO2(Bacillus pumilus DSM 32539)and CON groups.Supplementation of PRO1 decreased(P<0.05)lymphocyte counts on d 7 and 14 PI,compared with CON.Supplementation of PRO1 and PRO2 both reduced(P<0.05)total coliforms in mesenteric lymph nodes on d 21 PI.Pigs in PRO2 had greater(P<0.05)goblet cell number and sulfomucin percentage in duodenal villi and greater(P<0.05)sialomucin percentage in jejunal villi than pigs in CON.Supplementation of PRO1 up-regulated(P<0.05)MUC2 gene expression in jejunal mucosa and reduced(P<0.05)PTGS-2 and IL1B gene expression in ileal mucosa on d 21 PI,compared with CON.Pigs in PRO1 had reduced(P<0.05)relative abundance of families Lachnospiraceae,Peptostreptococcaceae and Pasteurellaceae in the ileum.Conclusions:Supplementation of Bacillus subtilis DSM 32540 improved growth performance,alleviated diarrhea severity,enhanced gut health,and reduced systemic inflammation of weaned pigs infected with ETEC F18.Although Bacillus pumilus DSM 32539 was able to alleviate systemic inflammation,it had limited impacts on growth performance and severity of diarrhea of ETEC F18 challenged weaned pigs. | Yijie He Cynthia Jinno Kwangwook Kim Zhaohai Wu Bie Tan Xunde Li Rose Whelan Yanhong Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 3 | Tensile Strain - Hardening Behavior of PVA - ECC 显示文摘 | Li Victor C Wang Shuxin Wu Cynthia | 2001 | ACI Journal of Materials2001，98，6： | 1 |
| 4 | Influence of reinforcing bars on shrinkage stresses in concrete slabs显示文摘 | Zhang Jun Li Victor C Wu Cynthia | 2000 | Journal of Engineering Mechanics2000，126，12： | 1 |
| 5 | Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation显示文摘 | Shaoguang Wu Patrice J. Morin Djik Maouyo Cynthia L. Sears | 2003 | Gastroenterology2003，，2： | 1 |
| 6 | Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography显示文摘 | Wenjuan S. Jobgen Scott C. Jobgen Hui Li Cynthia J. Meininger Guoyao Wu | 2006 | Journal of Chromatography B2006，，1： | 1 |
| 7 | Tensile strain-hardening behavior of polyvinyl alcohol engineered cementitious composite(PVA-ECC)显示文摘 | Victor C Li Shuxin Wang Cynthia Wu | 2001 | ACI Materials Journal2001，98，6： | 1 |
| 8 | Expanding southern whiteness:reconceptualizing ethnic difference in the short fiction of Carson McCullers显示文摘 | WU CYNTHIA | | 0，，01： | 1 |
| 9 | Measuring and Modifying Interface Proferities of PVA Fibers in ECC Matrix显示文摘 | Carl Redon Victor C Li Cynthia Wu | 2001 | Journal of Materials in Civil Engineering2001，13，6： | 1 |
| 10 | Tensile Strain-Hardening Behavior of Polyvinyl Alcohol Engineered Cementitious Composite (PVA-ECC)显示文摘 | VICTOR C Li WANG Shu-xin CYNTHIA Wu | 2001 | ACI Materials Journal2001，98，6： | 1 |
| 11 | Downregulated Expression of the Secreted Gly- coprotein Follistatin-like I (Fstll) is a Robust Hallmark of Preadipocyte to Adipocyte Conversion显示文摘 | Wu Y Zhou S Cynthia MS | 2010 | Mech Dev2010，127，34： | 1 |
| 12 | High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue显示文摘 | Wenjuan Jobgen Wenjiang J. Fu Haijun Gao Peng Li Cynthia J. Meininger Stephen B. Smith Thomas E. Spencer Guoyao Wu | 2009 | Amino Acids2009，，1： | 1 |
| 13 | Influence of Reinforcing Bars on Shrinkage Stress in Concrete Slabs显示文摘 | Zhang Jun Li Victor C Wu Cynthia | 2000 | Journal of Engineering Mechanics2000，126，12： | 1 |
| 14 | The serum immunoglobulin G glycosylation signature of gastric cancer显示文摘 | L. Renee Ruhaak Donald A. Barkauskas Javier Torres Cara L. Cooke Lauren D. Wu Carol Stroble Sureyya Ozcan Cynthia C. Williams Margarita Camorlinga David M. Rocke Carlito B. Lebrilla Jay V. Solnick | 2014 | EuPA Open Proteomics2014，，： | 1 |
| 15 | Tensile Strain-hardening BSehavior of PVA-ECC显示文摘 | Victor C Li Shuxin Wang and Cynthia Wu | 2001 | ACI Materials Journal2001，98，6： | 1 |
| 16 | Influence of reinforcing bars on shrinkage stresses in concrete slabs显示文摘 | Zhang Jun Li Victor C Wu Cynthia | 2000 | Journal of Engineering Mechanics2000，126，12： | 1 |
| 17 | The NHE1 Na^+/H^+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival显示文摘 | WU K L MARIA E B CYNTHIA D L F | 2004 | J Biol Chem2004，279，1： | 1 |
| 18 | Beneficial effects of l-arginine on reducing obesity: potential mechanisms and important implications for human health显示文摘 | Jason R. McKnight M. Carey Satterfield Wenjuan S. Jobgen Stephen B. Smith Thomas E. Spencer Cynthia J. Meininger Catherine J. McNeal Guoyao Wu | 2010 | Amino Acids2010，，2： | 1 |
| 19 | Important roles for the arginine family of amino acids in swine nutrition and production显示文摘 | Guoyao Wu Fuller W. Bazer Teresa A. Davis Laurie A. Jaeger Greg A. Johnson Sung Woo Kim Darrell A. Knabe Cynthia J. Meininger Thomas E. Spencer Yu-Long Yin | 2007 | Livestock Science2007，，1： | 1 |
| 20 | Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs显示文摘 | Winkler Thomas Hong So Gun Decker Jake E Morgan Mary J Wu Chuanfeng Hughes William M V Yang Yanqin Wangsa Danny Padilla-Nash Hesed M Ried Thomas Young Neal S Dunbar Cynthia E Calado Rodrigo T | 2013 | Journal of Clinical Investigation2013，，5： | 1 |
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