4篇
您的检索式：作者名="DAI Ruiping"
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| 1 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
| 2 | Fluorine-doped BiVO_(4) photocatalyst: Preferential cleavage of C−N bond for green degradation of glyphosate显示文摘With increasing concerns on the environment and human health,the degradation of glyphosate through the formation of less toxic intermediates is of great importance.Among the developed methods for the degradation of glyphosate,photodegradation is a clean and efficient strategy.In this work,we report a new photocatalyst by doping F ion on BiVO_(4) that can efficiently degrade glyphosate and reduce the toxic emissions of aminomethylphosphonic acid(AMPA)through the selective(P)−C−Ncleavage in comparison of BiVO_(4) catalyst.The results demonstrate that the best suppression of AMPA formation was achieved by the catalyst of 0.3F@BiVO_(4) at pH=9(AMPA formation below10%).In situ attenuated total reflectance Fourier transforms infrared(ATR-FTIR)spectroscopy indicates that the adsorption sites of glyphosate on BiVO_(4) and 0.3F@BiVO_(4) are altered due to the difference in electrostatic interactions.Such an absorption alteration leads to the preferential cleavage of the C−Nbond on the N−C−P skeleton,thereby inhibiting the formation of toxic AMPA.These results improve our understanding of the photodegradation process of glyphosate catalyzed by BiVO_(4)-based catalysts and pave a safe way for abiotic degradation of glyphosate. | Yunlong Chen Yingping Huang Hailin Tian Liqun Ye Ruiping Li Chuncheng Chen Zhongxu Dai Di Huang | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 3 | Genetic effects of historical anthropogenic disturbance on a long-lived endangered tropical tree Vatica mangachapoi显示文摘The endangered Vatica mangachapoi,a longlived,tropical tree with economic and ecological importance found in Hainan,China,was used to assess the hypothesis that historical human activities in Hainan's tropical rain forest could have negative effects on the genetic diversity of V.mangachapoi.Three hundred and twenty individuals from 11 natural populations—which were classified into three groups according to levels of disturbance—were sampled and analyzed with ISSRmarkers.Although genetic diversity of V.mangachapoi is high at the species level,it is relatively low within populations.A significant genetic differentiation occurs among different disturbance levels.Significant isolation-by-distance indicated relevant historical anthropogenic changes.Our findings showed that historical human disturbances significantly increase the genetic differentiation and slightly decrease the genetic diversity of long-lived tree V.mangachapoi.Relevant targeting conservation actions were recommended. | Zhicong Dai Chuncan Si Deli Zhai Ping Huang Shanshan Qi Ying Lin Ruiping Wang Qiongxin Zhong Daolin Du | 2018 | Journal of Forestry Research2018，29，2： | 0 |
| 4 | Research on Measurement Accuracy of the Double-Channel Microwave Power Sensors Based on an MEMS Cantilever Beam显示文摘A thermopile-based microwave power sensor and a double-channel microwave power sensor are compared in order to research the measurement accuracy of microwave power. The relationship of the displacement of MEMS cantilever beam with the measured microwave power is researched, and the reason that the microwave power consumed by the MEMS cantilever cannot be ignored at low power level is explained. The ratio of microwave power consumed by the MEMS cantilever with the microwave frequency is obtained, and the measured results show that the percentage is 51.96%@8GHz, 52.31%@10GHz and 55.11%@12GHz on the average, respectively. There is an important reference value to achieve the accurate microwave power measurement of the double-channel microwave power sensors. | WANG Debo WU Lele LI Longfei DAI Ruiping | 2019 | Chinese Journal of Electronics2019，28，5： | 0 |
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