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| 1 | Prognostic value of clinicopathological characteristics in patients with pancreatic cancer显示文摘Background:The purpose of this study was to analyze me effects of all clinical characteristics on the overall survival time,in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer.Methods:A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital,Shanghai Jiaotong University School of Medicine,between January 2002 and December 2012.There were 68 men and 35 women;the median age was 62 years.Diagnoses of pancreatic cancer in all patients were confirmed by histopathology,cytology,or clinical diagnosis.The Kaplan-Meier method was performed to calculate the overall survival rate.The log-rank method was used to examine the univariate analysis.The Cox regression model was performed for multivariate analysis.Results:The median survival time was 293 days,the 1-,2-,and 3-year survival rates were 27.18%,5.83%,and 1.94%,respectively.Cox regression analysis revealed that age(P=0.015),Karnofsky performance status(PS)(P=0.002),surgical types(P<0.001),and platelet counts(P<0.001) were independent prognostic factors affecting the overall survival of patients with pancreatic cancer.Conclusions:Pancreatic cancer had a poor prognosis,the general physical condition,age,the availability of radical surgery,and platelet counts were factors influencing the overall survival of patients with pancreatic cancer. | Mei Geng Haoping Xu Ruobing Ren Qing Qu Chengfang Shangguan Junwei Wu Jinsong Jiang Hao Li Weiguo Cao | 2015 | Chinese Journal of Cancer Research2015，27，5： | 4 |
| 2 | Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition显示文摘 | Xin Gong Jingxian Li Wei Shao Jianping Wu Hongwu Qian Ruobing Ren Peter Espenshade Nieng Yan | 2015 | Cell Research2015，25，4： | 3 |
| 3 | Reliable Ge_(2)Sb_(2)Te_(5) based phase-change electronic synapses using carbon doping and programmed pulses显示文摘Hardware electronic synapse and neuro-inspired computing system based on phase change random access memory(PCRAM)have attracted an extensive investigation.However,due to the intrinsic asymmetric reversible phase transition,the defective weight update of PCRAM synapses in aspects of tuning range,linearity and continuity has long required a system-level complexity of circuits and al-gorithms.The cell-level improvements to a great extent may slim the system thus achieving efficient computing.We report in this work the great enhancement of Ge_(2)Sb_(2)Te_(5)(GST)based PCRAM synapses by combining materials engineering and pulse programming.It is found that carbon doping in GST retards the rate of phase changing thus increasing the controllability of the conductance,while non-linear programmable pulse excitations can eventually lead to a reliable synaptic potentiation and depression.A set of improved programmable pulse schemes for spike-timing dependent plasticity was then demonstrated,suggesting its potential superiority in flexible programming and reliable data collection.Our methods and results are of great significance for implementing PCRAM electronic synapses and high-performance neuro-inspired computing. | Qiang Wang Gang Niu Ruobing Wang Ren Luo Zuo-Guang Ye Jinshun Bi Xi Li Zhitang Song Wei Ren Sannian Song | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 4 | Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism显示文摘The pituitary adenylate cyclase-activating polypeptide type I receptor(PAC1R)belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs.Abnormal activation of the receptor mediates trigeminovascular activation and sensitization,which is highly related to migraine,making PAC1R a potential therapeutic target.Elucidation of PAC1R activation mechanism would benefit discovery of therapeutic drugs for neuronal disorders.PAC1R activity is governed by pituitary adenylate cyclase-activating polypeptide(PACAP),known as a major vasodilator neuropeptide,and maxadilan,a native peptide from the sand fly,which is also capable of activating the receptor with similar potency.These peptide ligands have divergent sequences yet initiate convergent PAC1R activity.It is of interest to understand the mechanism of PAC1R ligand recognition and receptor activity regulation through structural biology.Here we report two near-atomic resolution cryo-EM structures of PAC1R activated by PACAP38 or maxadilan,providing structural insights into two distinct ligand binding modes.The structures illustrate flexibility of the extracellular domain(ECD)for ligands with distinct conformations,where ECD accommodates ligands in different orientations while extracellular loop 1(ECU)protrudes to further anchor the ligand bound in the orthosteric site.By structureguided molecular modeling and mutagenesis,we tested residues in the ligand-binding pockets and identified clusters of residues that are critical for receptor activity.The structures reported here for the first time elucidate the mechanism of specificity and flexibility of ligand recognition and binding for PACT R,and provide insights toward the design of therapeutic molecules targeting PAC1R. | Jia Wang Xianqiang Song Dandan Zhang Xiaoqing Chen Xun Li Yaping Sun Cui Li Yunpeng Song Yao Ding Ruobing Ren Essa Hu Harrington Liaoyuan AHu Wenge Zhong Cen Xu Xin Huang Hong-Wei Wang Yingli Ma | 2020 | Cell Research2020，30，5： | 1 |
| 5 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
| 6 | Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism显示文摘We noticed the missing structure deposition information in our manuscript published online on February 11,2020,which are the PDB codes and EMDB map entries of the structure PACAP38-PAC1R-GS(PDB code:6M1I and EMDB entry:EMD-30048)and maxadilan-PAC1R-Gs(PDB code:6M1H and EMDB entry:EMD-30047).We apologize for any inconvenience this missing information has caused.This correction does not affect the description of the results or the conclusion of this work. | Jia Wang Xianqiang Song Dandan Zhang Xiaoqing Chen Xun Li Yaping Sun Cui Li Yunpeng Song Yao Ding Ruobing Ren Essa Hu Harrington Liaoyuan AHu Wenge Zhong Cen Xu Xin Huang Hong-Wei Wang Yingli Ma | 2020 | Cell Research2020，30，5： | 0 |
| 7 | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein显示文摘Dear Editor,Takeda G protein-coupled receptor 5(TGR5),also known as G protein-coupled bile acids(BAs)receptor 1(GPBAR1),1 belongs to the class A GPCR subfamily.The major TGR5-dependent actions of BAs include maintaining energy homeostasis,regulating glucose/lipids metabolism,as well as immunosuppressive properties.2 TGR5 is identified as a potential therapeutic target for protecting hepatocytes from bile acid overload,preventing atherosclerosis,and inhibiting macrophage inflammation due to its critical role in bile acid sensitization.Thus,elucidation of structural characteristics of TGR5 and its activation mechanism would benefit the discovery of therapeutic drugs for these metabolic disorders. | Geng Chen Xiankun Wang Yunjun Ge Ling Ma Qiang Chen Huihui Liu Yang Du Richard DYe Hongli Hu Ruobing Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 8 | Novel 2D CaCl crystals with metallicity, room-temperature ferromagnetism, heterojunction, piezoelectricity-like property and monovalent calcium ions显示文摘Under ambient conditions,the only known valence state of calcium ions is+2,and the corresponding crystals with calcium ions are insulating and nonferromagnetic.Here,using cryo-electron microscopy,we report direct observation of two-dimensional(2D)CaCl crystals on reduced graphene oxide(rGO)membranes,in which the calcium ions are only monovalent(i.e.+1).Remarkably,metallic rather than insulating properties are displayed by those CaCl crystals.More interestingly,room-temperature ferromagnetism,graphene-CaCl heterojunction,coexistence of piezoelectricity-like property and metallicity,as well as the distinct hydrogen storage and release capability of the CaCl crystals in rGO membranes are experimentally demonstrated.We note that such CaCl crystals are obtained by simply incubating rGO membranes in salt solutions below the saturated concentration,under ambient conditions.Theoretical studies suggest that the formation of those abnormal crystals is attributed to the strong cation-πinteractions of the Ca cations with the aromatic rings in the graphene surfaces.The findings highlight the realistic potential applications of such abnormal CaCl material with unusual electronic properties in designing novel transistors and magnetic devices,hydrogen storage,catalyzers,high-performance conducting electrodes and sensors,with a size down to atomic scale. | Lei Zhang Guosheng Shi Bingquan Peng Pengfei Gao Liang Chen Ni Zhong Liuhua Mu Lijuan Zhang Peng Zhang Lu Gou Yimin Zhao Shanshan Liang Jie Jiang Zejun Zhang Hongtao Ren Xiaoling Lei Ruobing Yi Yinwei Qiu Yufeng Zhang Xing Liu Minghong Wu Long Yan Chungang Duan Shengli Zhang Haiping Fang | 2021 | National Science Review2021，8，7： | 0 |
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