|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Lysine requirement through the human显示文摘 | DANIEL T CECILE B | 2007 | J Nutr2007，137，： | 1 |
| 4 | Measurement of scenic beauty :the law of comparative judgment and scenic beauty estimation proce-dures 显示文摘 | Hulliv H B Buhyoff G J Daniel T C | 1984 | Forest Science1984，30，4： | 1 |
| 5 | Mechanism of AP - 1 - mediated gene expression by select organochlorines through the p38 MAPK pathway显示文摘 | Daniel E F Yan T B Beckman S | 2004 | Carcinogencsis2004，25，2： | 1 |
| 6 | Overall Es- sen's experience with the Evita open hybrid stent graft system and evolution of the surgical technique显示文摘 | Konstantinos T Daniel D Jamslav B | 2013 | Ann Cardiothorae Surg2013，2，： | 1 |
| 7 | Toxicity studies of 1,3- dichlorobenzene in Sprague-Dawley rats显示文摘 | McCauley P T Robinson M Daniel F B | 1995 | Drug and Chemical Toxicology1995，18，23： | 1 |
| 8 | Laboratory observations and numerical simulations of wave height attenuation in heterogeneous vegetation 显示文摘 | Philip J B Daniel T C WU W C | 2014 | Journal of Waterway Port Coastal and Ocean Engineering2014，140，1： | 1 |
| 9 | Isolation and iden tification of synthetic pyrethroid-degrading bacteria显示文摘 | GRANT R J DANIELL T J BETTS W B | 2002 | Journal of Applied Microbiology2002，92，3： | 1 |
| 10 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 11 | Effect of Chemical and Microbial Amendments on Ammonia Volatilization from Composting Poultry Litter显示文摘 | P B Delaune P A Moore Jr T C Daniel J L Lemunyon | 2004 | Journal of Environmental Quality2004，33，2： | 1 |
| 12 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents显示文摘 | Daniel T W Chu Prabhavathi B Fernandes Akiyo K Claibome | 1985 | J Med Chem1985，28，： | 1 |
| 13 | Identification of Monosaccharides by High-performance Liquid Chromatography Using Methanolysis and a Light-scattering Detector显示文摘 | Myriam T Arlette E B Danielle B F | 1990 | J Chromatogr1990，514，1： | 1 |
| 14 | Isolation and Identification of Synthetic Pyrethroid-degrading Bacteria 显示文摘 | Grant R J Daniell T J Betts W B | 2002 | Journal of Applied Microbiology2002，92，3： | 1 |
| 15 | Effect of Chemical and Microbial Amendments on Ammonia Volatilization from Composting Pluhry Litter 显示文摘 | P B DELAUNE P A MOORE JR T C DANIEL | 2004 | J Environ Qual2004，，33： | 1 |
| 16 | Extraction of lignin from sugar cane bagasse and Pinus taeda wood chips using ethanol-water mixture and carbon dioxide at high pressures显示文摘 | DANIEL P MARIA T B LUIZ h F | 2005 | The Journal of Supercritical Fluids2005，36，1： | 1 |
| 17 | Experimental examination of prechamber heat release in a large bore natural gas engine 显示文摘 | Daniel B Olsen Allan T Kirkpatrick | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，： | 1 |
| 18 | CE0 incentives and earnings management显示文摘 | Daniel B Philippon T | | 0，，80： | 1 |
| 19 | Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington' s disease显示文摘 | Daniel B R Rebecca T L Mark H M C | 2012 | Bioehem J2012，442，1： | 1 |
| 20 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员