|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington' s disease显示文摘 | Daniel B R Rebecca T L Mark H M C | 2012 | Bioehem J2012，442，1： | 1 |
| 3 | Global Cancer Statistics 显示文摘 | Lindsey A T Freddie B Rebecca L | 2015 | CA Cancer J Clin2015，65，2： | 1 |
| 4 | Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis显示文摘 | Anna L Paterson Maria O’Donovan Elena Provenzano Liam J Murray Helen G Coleman Brian T Johnson Damian T McManus Marco Novelli Laurence B Lovat Rebecca C Fitzgerald | 2013 | J Pathol2013，，1： | 1 |
| 5 | Interventions to Support a Palliative Care Approach in Patients with Chronic Obstructive Pulmonary Disease: an Integrative Review 显示文摘 | Rebecca T D David C C Jane L P | 2012 | International Journal of Nursing Studies2012，49，11： | 1 |
| 6 | Flow Cytometric immunophenotypic analysis of 306 cases of multiple myeloma 显示文摘 | Pei L Rebecca O Guido T | 2004 | American Journal of Clinical Pathology2004，121，4： | 1 |
| 7 | Globalcancer statistics,2012 显示文摘 | LINDSEY A T FREDDIE B REBECCA L S | 2015 | CA Cancer J2015，2015，1： | 1 |
| 8 | A laboratory evaluation of the laser in situ scattering and transmissometry instrument using natural sediments显示文摘 | Peter T Rebecca J L James D I | 1999 | Marine Geology1999，159，： | 1 |
| 9 | Contribution of storge and currently assimilated nitrofen to vegetative显示文摘 | Kelth T Birkhold Rebecca L | 1993 | J Amer Soc Hort Sci1993，118，1： | 1 |
| 10 | Contribution of storge and currently assimilated nitrofen to vegetative 显示文摘 | Kelth T Birkhold Rebecca L Darnell | 1993 | J Amer Soc Hort Sci1993，118，1： | 1 |
| 11 | Foreign-Body Reaction Mimicking Postneurosurgical Infection after Cranioplasty显示文摘 | Brett-Major David M Baraniak Sean M Gilhooly Jonathan E Christensen Rebecca L Grant Gerald T Armonda Rocco A Ganesan Anuradha | 2008 | Military Medicine2008，，7： | 1 |
| 12 | Early Identification and Linkage to Care of Persons with Chronic Hepatitis B Virus Infection - Three U.S. Sites, 2012-2014显示文摘 | Beckett Geoff A Ramirez Gilberto Vanderhoff Aaron Nichols Kim Chute Sara M Wyles David L Schoenbachler Ben T Bedell Deborah T Cabral Rebecca Ward John W | 2014 | Morbidity and Mortality Weekly Report2014，，18： | 1 |
| 13 | Flow di- verters for treatment of intracranial aneurysms: Current status and ongoing clinical trials显示文摘 | George K C Wong Marco C L Kwan Rebecca Y T Ng | 2011 | Journal of Clinical Neuroscience2011，18，： | 1 |
| 14 | Consequences of More Extreme Precipitation Regimes for Terrestrial Ecosystems显示文摘 | Knapp Alan K Beier Claus Briske David D Classen Aimée T Luo Yiqi Reichstein Markus Smith Melinda D Smith Stanley D Bell Jesse E Fay Philip A Heisler Jana L Leavitt Steven W Sherry Rebecca Smith Benjamin Weng Ensheng | 2008 | Bioscience2008，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员