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| 1 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 4 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hbwwupv9upuu06uq5.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 5 | Rainbow trout has two genes for growth hormone显示文摘 | Agellon L B Davies S L Lin C M | 1988 | Mol Rep Develop1988，1，： | 1 |
| 6 | The Barthel ADL Index:a reliability study显示文摘 | Wade DT Davies S | 1988 | Int Disability Study1988，10，： | 1 |
| 7 | miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting 显示文摘 | Esau C Davis S Murray S F | 2006 | Cell Metab2006，3，2： | 1 |
| 8 | Expression patterns of cell wall-modifying enzymes during grape berry development 显示文摘 | NUNAN K DAVIES C ROBINSON S FINCHER G | 2001 | Planta2001，214，2： | 1 |
| 9 | Mutations of the BRAF gene in human cancer显示文摘 | Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al | 2002 | Nature2002，417，： | 1 |
| 10 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 11 | An assessment of support vector machines for land cover classification 显示文摘 | HUANG C DAVIS L S TOWNSHEND J R G | 2002 | International Journal of Remote Sensing2002，23，4： | 1 |
| 12 | miR-122 regulation of lipid metabolism re- vealed by in vivo antisense targeting 显示文摘 | Esau C Davis S Murray SF | 2006 | Cell Metab2006，3，： | 1 |
| 13 | Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord显示文摘 | Davies S J A Goucher D R Doller C | | 0，，14： | 1 |
| 14 | Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression显示文摘 | Paoloni M Davis S Lana S Withrow S Sangiorgi L Picci P Hewitt S Triche T Meltzer P Khanna C | | 0，，： | 1 |
| 15 | Lesions in the cerebellar fastigial nucleus have a small effect on the hyperpnea needed to meet the gas exchange' requirements of submaximal exercise 显示文摘 | Martino PF Davis S Opansky C | 2006 | Appl Physiol2006，101，4： | 1 |
| 16 | The petroleum of Tertiary coal from western Indonesia:Relationship to mire type and sequence stratigraphic setting显示文摘 | Davis R C Noon S W Harrington J | 2007 | International Journal of Coal Geology2007，70，： | 1 |
| 17 | Determinationof the sedimentary microbial biomass by extractible lipidphosphate显示文摘 | White D C Davis W M Nickels J S | 1979 | Oecologia1979，40，1： | 1 |
| 18 | Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and eorticosterone显示文摘 | Thome U H Davis I C Nguyen S V | 2003 | Am J Physiol Lung Cell Mol Physiol2003，284，2： | 1 |
| 19 | The temperature of Europe during the Holoeene reconstructed from pollen data显示文摘 | Davis B A S Brewer S Stevenson A C | 2003 | Quaternary Science Reviews2003，22，1517： | 1 |
| 20 | In vitro degradation of novel poly (lactide - glycolide) 75/25 foam显示文摘 | Holy C E Dang S M Davies J E | 1999 | Biomaterials1999，20，13： | 1 |
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