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| 1 | Nutritional Status of Children during and post-Global Economic Crisis in China显示文摘Objective To describe the impact of the global economic crisis on the nutritional status of children in China during and after the crisis.Methods Data from 1990 to 2010 were sourced from the National Food and Nutrition Surveillance System.Approximately 16 000 children under 5 years old were selected using a stratified random cluster method from 40 surveillance sites.Anthropometric and hemoglobin measurements for children under 5 were conducted.Nutritional status was determined according to WHO child growth standards.Results Prevalence of underweight and stunting in children under 5 had a downward trend.Underweight prevalence was close to normal (less than 5%),with prevalence of stunting 12.6% in 2009 and 12.1% in 2010 in rural areas.Prevalence of stunting in infants under 6 months and 6‐12 months old in poorer rural areas increased from 5.7%‐9.1% and 6.7%‐12.5%,respectively,in 2008‐2009.This trend also continued post‐crisis in 2010.Prevalence of stunting in children left behind by mothers was 20%‐30% higher than in children the same age in general and poorer rural areas.Prevalence of anemia in children did not change in rural areas,but prevalence of anemia in all age groups increased in poorer rural areas,especially in children under 24 months old.Level reached 30%‐40% in 2009,and fluctuated in 2010.Conclusion The nutritional status of children under 5 was comparatively stable during and after the global economic crisis,attributable to the Chinese government's policy response.The nutritional status in poorer rural areas fluctuated in response to the economic crisis and,thus,relevant action and intervention must be taken immediately to help the most vulnerable population in poorer rural areas.A proper national nutritional strategy for children under 2 years old,including nutrition supplementation for pregnant women and in‐home fortification for complementary feeding,should be initiated. | CHEN ChunMing HE Wu WANG YuYing DENG LiNa JIA FengMei | 2011 | Biomedical and Environmental Sciences2011，24，4： | 22 |
| 2 | Data Dynamics Enabled Privacy-Preserving Public Batch Auditing in Cloud Storage显示文摘Many schemes have been present to tackle data integrity and retrievability in cloud storage. Few of existing schemes support data dynamics, public verification and protect data privacy simultaneously. We propose a public auditing scheme which enables privacy-preserving,data dynamics and batch auditing. A data updating information table is designed to record the status information of the data blocks and facilitate data dynamics. Homomorphic authenticator and random masking technologies are exploited to protect data privacy for data owners. The scheme employs a Trusted third party auditor(TTPA)to verify the data integrity without learning any information about the data content during the auditing process.The scheme also allows batch auditing so that TTPA can process multiple auditing requests simultaneously which greatly accelerates the auditing process. Security and performance analysis show that our scheme is secure and feasible. | REN Zhengwei WANG Lina WU Qianhong DENG Ruyi | 2014 | Chinese Journal of Electronics2014，23，2： | 6 |
| 3 | Pay special attention to the transformation products of PPCPs in environment显示文摘Pharmaceuticals and personal care products(PPCPs)have received increasing attention.However,their transformation products(TPs)and metabolites,sometimes even with environmental concentration and/or toxicity higher than their parent compounds,received attention far from enough.This study gives useful insight on the occurrence,fate and toxicity of PPCP TPs or metabolites in WWTPs,surface water and even drinking water,highlighting the necessity of studying the PPCP TPs formation,occurrence,toxicity and environment risk,and further evaluating the environmental risk caused by PPCPs comprehensively. | Lina Yin Bin Wang Honglin Yuan Shubo Deng Jun Huang Yujue Wang Gang Yu | 2017 | Emerging Contaminants2017，3，2： | 4 |
| 4 | mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration显示文摘Hair follicles(HFs)undergo cycles of degeneration(catagen),rest(telogen),and regeneration(anagen)phases.Anagen begins when the hair follicle stem cells(HFSCs)obtain sufficient activation cues to overcome suppressive signals,mainly the BMP pathway,from their niche cells.Here,we unveil that mTOR complex 1(mTORC1)signaling is activated in HFSCs,which coincides with the HFSC activation at the telogen-to-anagen transition.By using both an inducible conditional gene targeting strategy and a pharmacological inhibition method to ablate or inhibit mTOR signaling in adult skin epithelium before anagen initiation,we demonstrate that HFs that cannot respond to mTOR signaling display significantly delayed HFSC activation and extended telogen.Unexpectedly,BMP signaling activity is dramatically prolonged in mTOR signaling-deficient HFs.Through both gain-and loss-of-function studies in vitro,we show that mTORC1 signaling negatively affects BMP signaling,which serves as a main mechanism whereby mTORC1 signaling facilitates HFSC activation.Indeed,in vivo suppression of BMP by its antagonist Noggin rescues the HFSC activation defect in mTORC1-null skin.Our findings reveal a critical role for mTOR signaling in regulating stem cell activation through counterbalancing BMP-mediated repression during hair regeneration. | Zhili Deng Xiaohua Lei Xudong Zhang Huishan Zhang Shuang Liu Qi Chen Huimin Hu Xinyue Wang Lina Ning Yujing Cao Tongbiao Zhao Jiaxi Zhou Ting Chen Enkui Duan | 2015 | Journal of Molecular Cell Biology2015，7，1： | 3 |
| 5 | Mating System of Tricholoma giganteum显示文摘Microscopical examination demonstrated that Tricholoma giganteum basidia bear 4 basidiospores. Mating tests revealed that T. giganteum has a tetra-polar, heterothallic mating system. New types of factor B (Br) occurred as a result of recombination within the B-type mating factor. | FU Junsheng CAI Yanshan KE Lina LIN Shaoxia DENG Youjin XIE Baogui | 2007 | 食用菌学报2007，14，3： | 3 |
| 6 | Improved Fair and Dynamic Provable Data Possession Supporting Public Verification显示文摘A number of proposals have been suggested to tackle data integrity and privacy concerns in cloud storage in which some existing schemes suffer from vulnerabilities in data dynamics. In this paper, we propose an improved fairness and dynamic provable data possession scheme that supports public verification and batch auditing while preserves data privacy. The rb23Tree is utilized to facilitate data dynamics. Moreover, the fairness is considered to prevent a dishonest user from accusing the cloud service provider of manipulating the data. The scheme allows a third party auditor (TPA) to verify the data integrity without learning any information about the data content during the auditing process. Furthermore, our scheme also allows batch auditing, which greatly accelerates the auditing process when there are multiple auditing requests. Security analysis and extensive experimental evaluations show that our scheme is secure and efficient. | REN Zhengwei WANG Lina DENG Ruyi YU Rongwei | 2013 | Wuhan University Journal of Natural Sciences2013，18，4： | 2 |
| 7 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 8 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 9 | Increasing rainfed wheat yield by optimizing agronomic practices to consume more subsoil water in the Loess Plateau显示文摘Erratic rainfall and misalignment between the rainy season and the growing season of winter wheat greatly limit rainfed winter wheat yield in the Loess Plateau of China. To increase the grain yield of winter wheat in this region, the effects of different agronomic practices, including adjusting planting pattern(NR, narrow row spacing), increasing seeding rate(high seeding rate, HS), decreasing basal nitrogen rate and increasing top-dressed nitrogen rate(DBN), and replacing an old cultivar with a new cultivar(NC) on wheat yield were investigated for two consecutive years. The results showed that the current grain yield of rainfed winter wheat in the Loess Plateau could be increased to 5879–7093 kg ha^(-1) by HS, DBN and NC practices relative to the practice of high-yielding farmers(PF). The increased yield due to HS, DBN and NC was attributed to the higher number of spikes ha^(-1), 1000-grain weight, and kernels spike^(-1). Before the flowering stage, HS increased soil water consumption(SWC) in 1–3 m subsoil due to the higher plant population compared with that of PF, whereas DBN decreased SWC in the 0–2 m soil layer compared with that of PF. After the flowering stage, HS, DBN, and NC increased SWC by 8–16 mm in 2–3 m subsoil compared to PF. The water use efficiency(WUE) was increased under DBN and NC in comparison with PF.However, the WUE did not increase under HS as it had the highest evapotranspiration among the five treatments. Increasing the use of subsoil water during the late growth stage by optimizing agronomic practices or applying new cultivars with expansive roots should be the primary approach to increase rainfed winter wheat yield in this region. | Wenjia Yang Weijian Liu Yulin Li Shiwen Wang Lina Yin Xiping Deng | 2021 | The Crop Journal2021，9，6： | 2 |
| 10 | Semi-crosslinked polyacrylamides as high-resolution and dynamic self-coating sieving matrices for protein capillary electrophoresis显示文摘This paper describes non-gel capillary sieving electrophoresis employing semi-crosslinked polyacrylamide as a high performance and low viscous replaceable separation matrix for separation of non-denatured protein separation. Arising from the fine sieving and dynamic coating ability of this polymer, a mixture of basic proteins lysozyme, cytochrome C, ribonuclease A, and trypsin was resolved with excellent reproducibility. Mixing different semi-crosslinked polyacrylamides together further improves the separation. The separtion mechanism was analyzed. With network structure developed to an intermediate state between crosslinked gel and linear polymer solutions, these semi-crosslinked polyacrylamide polymers demonstrate a promise as a new class of size sieving separation medium, not only in capillary electrophoresis, but also in microfluidic chip separation schemes. | ZHOU Jin XU JianDong XIE Yao QU Feng DENG YuLin GENG LiNa | 2008 | Chinese Science Bulletin2008，53，19： | 2 |
| 11 | Design and development of SiC/(W,Ti)C gradient ceramic nozzle显示文摘The idea of functionally gradient material (FGM) theory was used to design ceramic nozzle based on the erosion wear behaviors of the ceramic nozzles and the out- standing properties of FGM. The purpose is to reduce the tensile stress at the entry region of the nozzle during sand blasting processes. The design theory and methods of gradient ceramic nozzle were proposed. The physical, micromechanical, and composition distribution models of gradient ceramic nozzle were established. The optimum composition distribution of the gradient ceramic nozzle material was determined from the solution of the multi-objective optimization calculation by constructing the models of the composition distribution versus the structural in- tegrity of the compact in fabricating process. Results showed that compressive residual stresses appeared at the entry area of the gradient ceramic nozzle. The optimized component distribution exponent p is 0.5. An SiC/(W,Ti)C gradient ce- ramic nozzle material was synthesized by hot-pressing according to the design result. Results showed that the surface Vickers hardness of the FGM-1 gradient ceramic nozzle materials was greatly improved in comparison with that of the other layers. | LIU LiLi DENG JianXin WANG Yi ZHU LiNa | 2008 | Science China(Technological Sciences)2008，51，1： | 2 |
| 12 | CNN-BiLSTM-Attention Model in Forecasting Wave Height over South-East China Seas显示文摘Though numerical wave models have been applied widely to significant wave height prediction,they consume massive computing memory and their accuracy needs to be further improved.In this paper,a two-dimensional(2D)significant wave height(SWH)prediction model is established for the South and East China Seas.The proposed model is trained by Wave Watch III(WW3)reanalysis data based on a convolutional neural network,the bidirectional long short-term memory and the attention mechanism(CNNBiLSTM-Attention).It adopts the convolutional neural network to extract spatial features of original wave height to reduce the redundant information input into the BiLSTM network.Meanwhile,the BiLSTM model is applied to fully extract the features of the associated information of time series data.Besides,the attention mechanism is used to assign probability weight to the output information of the BiLSTM layer units,and finally,a training model is constructed.Up to 24-h prediction experiments are conducted under normal and extreme conditions,respectively.Under the normal wave condition,for 3-,6-,12-and 24-h forecasting,the mean values of the correlation coefficients on the test set are 0.996,0.991,0.980,and 0.945,respectively.The corresponding mean values of the root mean square errors are measured at 0.063 m,0.105 m,0.172 m,and 0.281 m,respectively.Under the typhoon-forced extreme condition,the model based on CNN-BiLSTM-Attention is trained by typhooninduced SWH extracted from the WW3 reanalysis data.For 3-,6-,12-and 24-h forecasting,the mean values of correlation coefficients on the test set are respectively 0.993,0.983,0.958,and 0.921,and the averaged root mean square errors are 0.159 m,0.257 m,0.437 m,and 0.555 m,respectively.The model performs better than that trained by all the WW3 reanalysis data.The result suggests that the proposed algorithm can be applied to the 2D wave forecast with higher accuracy and efficiency. | Lina Wang Xilin Deng Peng Ge Changming Dong Brandon J.Bethel Leqing Yang Jinyue Xia | 2022 | Computers, Materials & Continua2022，，10： | 2 |
| 13 | Effects of Chemical Composition and Microstructure on Exudation of Fused Cast AZS Refractory Materials显示文摘The fused cast alumina-zirconia-silica(AZS)refractory is an indispensable material of the glass melting furnace,because of its outstanding corrosion resistance and low pollution to glass production.The exudation is one important index to evaluate the performance of fused cast AZS refractory products.In order to study the effects of chemical composition and microstructure on the exudation of fused cast AZS refractory materials,three types of fused-cast AZS refractory bricks(AZS33#,AZS36#and AZS41#)were selected from several companies as the research object,and their composition,bulk density,apparent porosity,the value of exudation,static corrosion rate and microstructure were discussed.The results show that the chemical composition,especially the content of SiO2 and Na2O,and the distribution of zirconia would greatly affect the content and viscosity of glass phase,thus affecting the glass exudation.This work will provide technical reference for the development of low exudation AZS refractories. | YI Shuai DENG Lina ZENG Luju XUE Fei PAN Chuancai LIN Guowei LIU Yueqiang ZHANG Hang XIE Jinli | 2019 | China's Refractories2019，28，2： | 1 |
| 14 | Silicon-mediated changes in polyamine and 1-aminocyclopropane-1-carboxylic acid are involved in silicon-induced drought resistance in Sorghum bicolor L显示文摘 | Lina Yin Shiwen Wang Peng Liu Wenhua Wang Dan Cao Xiping Deng Suiqi Zhang | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 15 | Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer显示文摘 | Lingeng Lu Guangjian Zhu Chong Zhang Qian Deng Dionyssios Katsaros Susan T. Mayne Harvey A. Risch Lina Mu Emilie Marion Canuto Gianluca Gregori Chiara Benedetto Herbert Yu | 2012 | Breast Cancer Research and Treatment2012，，3： | 1 |
| 16 | Preparation and characterization of 3-(triethoxysilyl) propyl isocyanate self-assembled monolayer on surface of chip显示文摘Monolayer of 3-(triethoxysilyl) propyl isocyanate was prepared on the slide by self-assembled tech-nique. X-ray photoelectron spectroscopy (XPS) was employed to analyze the elementary composition of the film. Contact angle of distilled water was measured to characterize the surface state. It was shown that 3-(triethoxysilyl) propyl isocyanate had been successfully assembled on the slide. The in-crease of contact angle to 80° demonstrated that the hydrophobicity of the surface of chip was in-creased significantly. Moreover, further self-assembly of bovine serum albumin (BSA) on 3-(trietho- xysilyl) propyl isocyanate was also carried out with the advantages such as simple and convenient preparation. Therefore, the potential of broader applications in the modification of micro-channel in the μ-TAS system, the immobilization of protein or peptide and the surface modification of materials are all expectative. | XIE Yao GENG LiNa QU Feng LUO AiQin DENG YuLint | 2009 | Chinese Science Bulletin2009，54，5： | 1 |
| 17 | Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets显示文摘Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary diseases.Meanwhile,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in mice.However,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely unclear.Methods:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying mechanisms.In vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,respectively.Three female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were collected.In vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying mechanisms.Results:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and immunity.In addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier function.Furthermore,the in-vitro results showed that TUDCA improved the E.coli-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein expression.However,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in E.coli-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this process.Conclusions:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets,suggesting the potential application of TUDCA in improving gut health in piglet production. | Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang Shu Xianyong Ma Qingyan Jiang Songbo Wang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 18 | A genome wide association study between copy number variation (CNV) and human height in Chinese population显示文摘Copy number variation (CNV) is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height (with borderline significant p value: 0.013, 0.011, 0.024, 0.049; respectively). However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number (more than 2 copies) at 8p23.3-23.2 was associated with lower height (normal copy number vs. gain of copy number: 161.2 cm vs. 153.7 cm, p = 0.011), which accounted for 0.9% of height variation. Loss of copy number (less than 2 copies) at 6p21.3 was associated with 0.8% lower height (loss of copy number vs. normal copy number: 154.5 cm vs. 161.1 cm, p = 0.013). Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Xi Li Lijun Tan Xiaogang Liu Shufeng Lei Tielin Yang Xiangding Chen Fang Zhang Yue Fang Yan Guo Liang Zhang Han Yan Feng Pan Zhixin Zhang Yumei Peng Qi Zhou Lina He Xuezhen Zhu Jing Cheng Lishu Zhang Yaozhong Liu Qing Tian Hongwen Deng | 2010 | Journal of Genetics and Genomics2010，37，12： | 1 |
| 19 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
| 20 | A regulatory perspective on recombinant collagen-based medical devices显示文摘As a class of novel biomaterials manufactured by synthetic biology technologies,recombinant collagens are candidates for a variety of medical applications.In this article,a regulatory scientific perspective on recombinant collagens and their medical devices is presented with a focus on the definition,translation,classification and technical review.Recombinant collagens are categorized as recombinant human collagen,recombinant humanized collagen and recombinant collagen-like protein,as differentiated by specific compositions and structures.Based on their intended uses and associated risks,recombinant collagen-based medical devices are generally classified as Class Ⅱ or Ⅲ in China.The regulatory review of recombinant collagen-based medical devices aims to assess their safety and efficacy demonstrated by scientific evidences generated from preclinical and clinical evaluations.Taken together,opportunities as well as challenges for their future clinical translation of recombinant collagen-based medical devices abound,which highlights the essential role of regulatory science to provide new tools,standards,guidelines and methods to evaluate the safety and efficacy of medical products. | Wenbo Liu Hai Lin Peng Zhao Lina Xing Jie Li Zehua Wang Shan Ju XinLi Shi Yinghui Liu Gang Deng Guobiao Gao Lei Sun Xindong Zhang | 2022 | Bioactive Materials2022，7，6： | 1 |
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