|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | High energy ballmilled Pt and Pt-Ru catalysts for polymer electrolyte fuel cell and their tolerance to CO显示文摘 | DENIS M C LADANDE G GUAY D | 1999 | J Appl Electrochem1999，29，8： | 1 |
| 3 | Synthesis and electrochemical properties of numerous classes of vanadates 显示文摘 | DENIS S BAUDRIN E ORSINI F OUVRARD G TOUBOUL M TARSCOM J M | 1999 | J Power Sources1999，8182，： | 1 |
| 4 | Saturated faTTy acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus:implications for the pathogenesis of obesity显示文摘 | Milanski M Degasperi G Coope A Morari J Denis R Cintra D E Tsukumo D M Anhe G | | 0，，02： | 1 |
| 5 | Tests to determine performance of deformed welded wire fabric stirrups显示文摘 | Andrew G William C D Denis M | 1994 | ACI Structural Journal1994，91，2： | 1 |
| 6 | Low virulence bacterial in-fections of intervertebral discs and the resultant spinal dis-ease processes显示文摘 | Coscia MF Wack M Denys G | 2003 | Eur Radiol2003，18，： | 1 |
| 7 | BS5500 appendix d: an assessment based on wide plate brittle fracture test data显示文摘 | DAWES M G DENYS R | 1984 | Int J Press Vessel Piping1984，15，： | 1 |
| 8 | Continuous determination of residual chlorite in water显示文摘 | Denis M Minon G Masschelein W J 1989 | 1989 | Anal Chim Acta1989，226，： | 1 |
| 9 | Limitations of CD44v6 amplification for the detection of tumor cells in the blood of colorectal cancer patients显示文摘 | Masson D Denis M G Lustenberger P | 2000 | Br J Cancer2000，82，7： | 1 |
| 10 | Strategies to reduce to reduce methane emissions from farmed ruminants grazing on pasture显示文摘 | Buddle B M Denis M Attwood G T | 2011 | The Veterinary Journal2011，188，1： | 1 |
| 11 | EMG power spectra of elbow extensorsduring ramp and step isometric contraction显示文摘 | MARTIN B M BERTRAND A DENIS G | 1991 | Eut J Apply Physio1991，63，： | 1 |
| 12 | Targeted ovarian cancer treatment:the TRAILs of resistance显示文摘 | Nadzeva G K Denis L Isabelle M | | 0，，01： | 1 |
| 13 | Development of a vaccine to mitigate greenhouse gasemissions in agriculture: vaccination of sheep with methanogen fractions induces antibodies that block methane production in vitro 显示文摘 | WEDLOCK D N PEDERSEN G DENIS M | 2010 | New Zealand Veteri- nary Journal2010，58，1： | 1 |
| 14 | Obstructive sleep apnea and Resistant hyertension A case-control study 显示文摘 | Sandro CG Denis M Miguel G | 2007 | Chest2007，132，： | 1 |
| 15 | Leptin and reproduction显示文摘 | Denis A M Huan G M Christopher T F | 1998 | Endocrinologist1998，，8： | 1 |
| 16 | Detection of disseminated tumor cells in peripheral blood of colorectal cancer patients显示文摘 | Denis M G Lipart C Leborgne J | 1997 | Int J Cancer1997，74，5： | 1 |
| 17 | Low virulence bacterial infections of intervertebral disk disease,Clinical and pulse sequence considerations显示文摘 | Coscia MF Wack M Deny G | | 0，，01： | 1 |
| 18 | A Novel, Mitogen-Activated Nuclear Kinase Is Related to a Drosophila Developmental Regulator 显示文摘 | Denis G V Green M R | 1996 | Genes Dev1996，10，3： | 1 |
| 19 | Strategies to reduce to reduce methane emissions from farmed ruminants grazing on pasture 显示文摘 | BUDDLE B M DENIS M ATTWOOD G T | 2011 | The Veteri- nary Journal2011，188，1： | 1 |
| 20 | The evaluation of renal function and disease in patients with cirrhosis显示文摘 | Claire F Denis G Richard M | 2010 | Hepatology2010，52，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员