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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Pulmonary involvement in inflammatory bowel disease显示文摘AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subjects were enrolled in this prospective study.Detailed clinical information was obtained.Extent and activity of the bowel disease were established endoscopically.Each patient underwent pulmonary function tests and high-resolution computed tomography(HRCT).Blood samples for measurement of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),angiotensin converting enzyme and total IgE were delivered by the patients.RESULTS:Ten(25.6%)patients had respiratory symptoms.A pulmonary function abnormality was present in 22 of 39 patients.Among all patients,the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s(FEV1),FEV1/forced vital capacity(FVC),forced expiratory flow(FEF)25%-75%,transfer coefficient for carbon monoxide(DLCO),DLCO/alveolar volume.Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients.Endoscopic and clinical activities in UC patients were correlated with FEV1,FEV1/FVC,and FEF 25%-75%.Smoking status,duration of disease and medication were not correlated with pulmonary physiological test results,HRCT abnormalities,clinical/endoscopic disease activity,CRP,ESR or total IgE level or body mass index.CONCLUSION:It is important that respiratory manifestations are recognized and treated early in IBD.Otherwise,they can lead to destructive and irreversible changes in the airway wall. | Aydin Yilmaz Nilgün Yilmaz Demirci Derya Hosgün Enver ner Yurdanur Erdogan Atila Gkek Atalay aglar | 2010 | World Journal of Gastroenterology2010，16，39： | 15 |
| 3 | Radical prostatectomy in patients aged 75 years or older:review of the literature显示文摘Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological age.As a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit.As perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be addressed.It is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after treatment.Moreover,elderly patients also demonstrate worse postoperative recovery of continence and erectile function.As the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients. | Philipp Mandel Thenappan Chandrasekar Felix K Chun Hartwig Huland Derya Tilki | 2019 | Asian Journal of Andrology2019，21，1： | 2 |
| 4 | An incremental genetic algorithm for classification and sensitivity analysis of its parameters显示文摘 | GOZDE B DERYA B ALP K | 2011 | System with Appli- cation2011，38，3： | 1 |
| 5 | Influence of different dietary oil sources on performance and cholesterol content of egg yolk in laying hens显示文摘 | KEMAL K DERYA Y SEHER K | 2010 | Journal of Biological Environment Science2010，4，12： | 1 |
| 6 | Preparation and characterization of UV-curable epoxy/silica nanocomposite coatings 显示文摘 | DERYA I NILHAN K A ATILLA G | 2009 | Progress in Organic Coatings2009，65，： | 1 |
| 7 | Preparation and characterization of UV- curable epoxy/silica nanocomposite coatings 显示文摘 | Derya 1 Nilhan K A Atilla G | 2009 | Progress in Organic Coatings2009，65，： | 1 |
| 8 | Serum cardiac markers in patients with acute myocardial infarction:oxidative stress,C-reactive protein and N-terminal probrain natriuretic peptide显示文摘 | Secil K Aymelek G Derya E | 2007 | J Clin Biochem2007，41，1： | 1 |
| 9 | Quality of life after colorectal surgery:A prospective study of patients compared with their spouses显示文摘BACKGROUND Although radical surgery for colorectal cancer improves the oncological outcomes,a significant portion of patients suffer from alterations in their quality of life(QoL).There are many studies investigating the QoL of patients who have colorectal cancer but none of these focus on the QoL of spouses.AIM To compare the QoL of patients after colorectal surgery to the QoL of spouses.METHODS This prospective study consisted of patients who were married and who underwent surgery at the University of Ankara,Department of Surgery between March 2006 and November 2010.Patients’spouses were also enrolled.The study was approved by the Ethics Committee of the Faculty of Medicine,Ankara University,and all patients provided written informed consent.The study included patients who underwent curative surgery for colorectal carcinoma[n=100;abdominoperineal excision(n=33),low anterior resection(n=33),left hemicolectomy(n=34)]and their spouses(n=100).The patients and spouses completed the Medical Outcome Study 36-item Short Form Survey(SF-36)and the World Health Organization Disability Assessment Schedule II(WHODAS-II)preoperatively and at postoperative months 15 to 18.RESULTS During this 4.5-year study period,273 patients with sigmoid or rectal cancer were admitted to the hospital.Of these patients,119 were eligible and willing to participate.Eleven patients had either systemic or locally inoperable disease,three patients had a severe surgical complication,and five patients were lost to followup.Therefore,a total of 100 patients completed the follow-up period.There was a statistically significant positive correlation between the disability scores of patients and the scores of their spouses for some of the WHODAS-II subscales,such as“self-care,”“life activities,”and“participation in society,”as well as for the total WHODAS-II score.There was also a positive correlation between the QoL of patients and the QoL of their spouses in most of the SF-36 subscales.Statistically significant correlations were observed for the“bodily pain,”“general health,””vitality,”“social function,”“emotion,”“mental health,”and mental component summary score subscales of the SF-36.When gender differences were evaluated,the QoL of male patients’spouses changed more when compared with female patients’spouses for all of the WHODAS-II subscales.Colorectal cancer surgery has a significant effect on the QoL of both patients and their spouses,these effects were more significant among male patients’spouses.CONCLUSION Preoperative counseling regarding potential problems should therefore collectively address patient and their spouse as a couple rather than the patient alone,particularly for patients undergoing low anterior resection and abdominoperineal resection procedures. | Gökçe Aylaz Cihangir Akyol Akın Fırat Kocaay Derya Gökmen Ayşe Burcu Yavuzarslan Ayhan Bülent Erkek Mehmet Ayhan Kuzu | 2021 | World Journal of Gastrointestinal Surgery2021，13，9： | 1 |
| 10 | Serum Visfatin Levels,Adiposity and Glucose Metabolism in Obese Adolescents显示文摘 | Derya T Birgül K Tercan U | 2012 | J Clin Res Pediatr Endocrinol2012，4，2： | 1 |
| 11 | Serum Cardiac Markers in Patients with AcuteMyocardial Infarction:Oxidative Stress,C-Reactive Protein and N-TerminalProbrain Natriuretic Peptide显示文摘 | Secil K Aymelek G Derya E | | J Ciin Biochem-0070，41，： | 1 |
| 12 | Preparation and characterization of UV-curable epoxy/silica nanocomposite coatings显示文摘 | DERYA I NILHAN K A ATILLA G | 2009 | Prog Org Coat2009，65，： | 1 |
| 13 | Serum cardiac markersin patients with acute myocardial infraction : oxidative stress,C -reactive protein and N - terminal probrain natriuretic peptide 显示文摘 | SECIL K AYMELEK G DERYA E | 2007 | JClin Biochem2007，41，1： | 1 |
| 14 | Determination of rare earth elements in seawater by inductively coupled plasma mass spectrometry with off-line column preconcentration using 2,6-diacetylpyridine functionalized Amberlite XAD- 4 显示文摘 | Cennet K Derya K Andrew F | 2011 | Analytica Chimica Acta2011，689，： | 1 |
| 15 | Effect of uncertainty on water distribution system model design decisions显示文摘 | DERYA S LANSEY K | 2009 | Journal of Water Resources Planning and Management2009，135，1： | 1 |
| 16 | Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis 显示文摘 | GULDEN B MEVLUT B DERYA K | 2007 | Clinical Biochemistry2007，40，11： | 1 |
| 17 | In vitro synergistic activity of tigecycline and colistin against XDR- Acinetobacter baumannii显示文摘 | Murat D Derya K T Meltem Y C | 2010 | JAntibiot2010，63，2： | 1 |
| 18 | Serum cardiac makers in patients with acute myocardial infarction:oxidative stress,C-reactiveprotein and N-terminal probrain nauiuretic peptide显示文摘 | Sceil K Aymelek G Derya E | | 0，，01： | 1 |
| 19 | An anti-tumor coup:TIM3 ablation activates the immune arsenal显示文摘In a recent study published in Nature,Dixon et al.^(1) showed that TIM3 adjusts“tumor immune temperature”via the involvement of dendritic cells(DCs)with an altered inflammasome activity.Ablation of TIM3 in DCs primarily escalated inflammasome activation and bolstered stem-like CD8^(+)T cells leading to anti-tumor immunity.^(1) | KıvançGörgülü Derya Kabacaoğlu Hana Algül | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 20 | Validity and reliability of the complementary and integrative health assessment for practitioners scale: CIHAP_(TR)显示文摘Objective:This study aimed to evaluate the validity and reliability of the Complementary and Integrative Health Assessment for Practitioners Scale for Turkish society.Methods:This methodological study was conducted between May~June 2020.The participants were 132 health care practitioners including nurses,physicians,dietitians,physiotherap ists,and psychologists,who were working in 6 different hospitals,and 4 different provinces in Turkey.Content Validity Index,item scale correlations,confirmatory factor analysis were used to evaluate validity.Cronbach’s alpha and test-retest were use d to evaluate reliability.Results:CVI was 0.95(0.81-0.98).Factor loadings ranged from 0.381 to 0.913 and,item scale correlations ranged from 0.302 to 0.837.The Cronbach’s alpha value was found 0.93 in the current study.Intraclass Correlation Coeffic ient ranged from 0.82 to 0.96.Conclusion:CIHAP was found to be valid and reliable tool for Turkish society. | Sadık Hançerlİoğlu İsmail Toygar DeryaÇinar | 2021 | TMR Integrative Nursing2021，5，2： | 0 |
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