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| 1 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 2 | Combination Patterns and Depositional Characteristics of Ordovician Carbonate Banks in the Western Tarim Basin,China显示文摘碳酸盐银行的联合模式和 depositional 特征在西方的 Tarim 盆基于奥陶纪的露头节,薄节,和碳同位素被调查,中国。四个碳酸盐银行联合模式在奥陶纪被扔,西方的 Tarim 盆,包括:礁石银行建筑群(RBC ) , Algae-Reef-Bank Interbed (ARBI ) ,厚层的蛋糕沉积银行(TLCAB ) ,和薄层的蛋糕逆行银行(TLCRB ) 。所有联合模式垂直地显示出清楚的时期。RBC 主要由礁石和 bioclastic 银行组成,并且 RBC 的尺寸取决于礁石的规模。Bioclastic 银行存款包围礁石。ARBI 的范围被水藻礁石,水藻 peloid 白云石 microfacies 和垂直地轮流出现的海藻的白云石 microfacies 沉积物的规模决定。当在周期叠并且与生气床上用品广泛地延长的层蛋糕发展了, TLCAB 和 TLCRB 被扔。TLCAB 和 TLCRB 的谷物是多样的并且多来源。与影响相对的海水平变化,生物发展和地形学, ARBI, TLCAB 或 TLCRB, RBC 连续地从更低的奥陶纪 Penglaiba 形成被开发到中间的奥陶纪 Yijianfang 形成。奥陶纪的 depositional 环境分析显示 RBC 和 ARBI 能形成有效的油和煤气的水库,并且 TLCAB 和 TLCRB 有潜力形成巨大的规模油和煤气的水库并且以后是为奥陶纪碳酸盐银行的探索的关键目标。 | HU Xiaolan FAN Tailiang GAO Zhiqian YU Bingsong CHEN Xiaozhi WANG Hongyu WANG Jianping LI Rangbin DING Meng LI Yifan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 7 |
| 3 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 4 | Hierarchical Optimization of Landing Performance for Lander with Adaptive Landing Gear显示文摘A parameterized dynamics analysis model of legged lander with adaptive landing gear was established. Based on the analysis model, the landing performances under various landing conditions were analyzed by the optimized Latin hypercube experimental design method. In order to improve the landing performances, a hierarchical optimization method was proposed considering the uncertainty of landing conditions. The optimization problem was divided into a higher level(hereafter the 'leader') and several lower levels(hereafter the 'follower'). The followers took condition?ing factors as design variables to find out the worst landing conditions, while the leader took bu er parameters as design variables to better the landing performance under worst conditions. First of all, sensitivity analysis of landing conditioning factors was carried out according to the results of experimental design. After the sensitive factors were screened out, the response surface models were established to reflect the complicated relationships between sensi?tive conditioning factors, bu er parameters and landing performance indexes. Finally, the response surface model was used for hierarchical optimization iteration to improve the computational e ciency. After selecting the optimum bu er parameters from the solution set, the dynamic model with the optimum parameters was simulated again under the same landing conditions as the simulation before. After optimization, nozzle performance against damage is improved by 5.24%, the acceleration overload is reduced by 5.74%, and the primary strut improves its performance by 21.10%. | Zongmao Ding Hongyu Wu Chunjie Wang Jianzhong Ding | 2019 | Chinese Journal of Mechanical Engineering2019，32，2： | 4 |
| 5 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 6 | HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia显示文摘Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are all embryonic lethal (Huo et al., 2009). Recently, significant phenotype and physiology differences have been reported between SIRT6- null mice and the non-human primate model (Zhang et al., 2018). Thus, an appropriate non-human primate model is needed for human β-thalassemia studies and treatments. | Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng Hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei Fang Canquan Zhou Shihua Yang Junjiu Huang | 2019 | Protein & Cell2019，10，7： | 4 |
| 7 | Influence of lunar regolith compressibility on sampling performance of thick wall spiral drills显示文摘A 2 m class robotic drill was sent to the Moon and successfully collected and returned regolith samples in late 2020 by China.It was a typical thick wall spiral drill(TWSD)with a hollow auger containing a complex coring system to retain subsurface regolith samples.Before the robotic drill was launched,a series of laboratory tests were carried out to investigate and predict the possible drilling loads it may encounter in the lunar environment.This work presents how the sampling performance of the TWSD is affected by the regolith compressibility.Experiments and analysis during the drilling and sampling process in a simulated lunar regolith environment were conducted.The compressibility of a typical lunar regolith simulant(LRS)was measured through unidirectional compression tests to study the relationship between its inner regolith stress and bulk density.A theoretical model was established to elucidate the cutting discharge behavior by auger flights based on the aforementioned relationship.Experiments were conducted with the LRS,and the results show that the sampling performance is greatly affected by the flux of the drilled cuttings into the spiral flight channels.This work helped in scheduling reasonable drilling parameters to promote the sampling performance of the robotic drill in the Chinese Chang’E 5 mission. | Yong PANG Tao ZHANG Hongyu WEI Ting ZENG Yinliang ZHANG Guidong MO Kun XU Shen YIN Guoxin WANG Xingwang ZHANG Xiaoming LAI Xilun DING | 2023 | Chinese Journal of Aeronautics2023，36，2： | 2 |
| 8 | An ultrasonic-ionic liquid process for the efficient acid catalyzed hydrolysis of feather keratin显示文摘A novel efficient method for hydrolyzing feather keratin using an ultrasonic-ionic liquid coupling process has been developed, with reaction conditions optimized using response surface analysis of data obtained from single factor optimization studies. Ultrasonic irradiation(225 W power) of feathers in 8.4 mol·L^(-1) hydrochloric acid containing 1-butyl-3-methylimidazolium chloride as a cosolvent at 80 °C for 1.4 h, followed by heating at 110 °C for 8.3 h, resulted in hydrolysis of their keratin component in an excellent 83.1% yield. Compared with previous methods, this new method employs reduced amounts of hydrochloric acid, shorter reaction time, and affords amino acid hydrolysis products in higher yield. | Song Ding Yang Sun Hongyue Chen Chao Xu Yi Hu | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 1 |
| 9 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 10 | 3D Face Recognition Based on Multiple Keypoint Descriptors and Sparse Representation 显示文摘 | Zbang Lin Ding Zhixuan Li Hongyu | 2014 | PLOS One2014，9，6： | 1 |
| 11 | Expression of pin1 and ki67 in cervical cancer and their significance显示文摘 | Li Hongyu Shen Hongling Xu Qian Deng Dongrui Wang Shixuan Lu Yunping Ma Ding | 2006 | Journal of Huazhong University of Science and Technology [Medical Sciences]2006，，： | 1 |
| 12 | Combination Patterns and Depositional Characteristics of Ordovician Carbonate Banks in the Western Tarim Basin, China显示文摘 | HU Xiaolan FAN Tailiang GAO Zhiqian YU Bingsong CHEN Xiaozhi WANG Hongyu WANG Jianping LI Rangbin DING Meng LI Yifan | 2012 | Acta Geologica Sinica ‐ English Edition2012，，4： | 1 |
| 13 | Incidence of diverse integrons and /3-1actamase genes in environmental Enterobacteriaceae isolates from Jiaozhou Bay, China显示文摘 | WANG Chunyan DANG Hongyue DING Yongsh- eng | 2008 | World Journal of Micro- biology and Biotechnology2008，24，： | 1 |
| 14 | Enhanced photo-hydrogen production of Rhodopseudomonas Faecalis RLD-53 by EDTA addition显示文摘 | REN Hongyu LIU Bingfeng DING Jie | 2012 | International Journal of Hydrogen Energy2012，37，： | 1 |
| 15 | In-situ photoisomerization of azobenzene to inhibit ion-migration for stable high-efficiency perovskite solar cells显示文摘Ion migration is a notorious problem in perovskite solar cells(PSCs)that severely mutilates device performance.Herein,a strategy to inhibit ion migration in situ is developed by using photoisomerization of azobenzene(AZO)to immobilize cations in the lattice.During the nucleation process,the photoisomerized cis-AZO reacts with FA^(+),MA^(+)and Pb2+cations in the perovskite precursor by synergistic cation-πinteraction and Lewis base coordination,leading to heterogeneous nucleation to produce uniform perovskite film.Meanwhile,it accelerates conversion of intermediate yellowδ-phase to desired black aphase of FAPb I3for improved crystallinity with well-passivated grain surface.Consequently,defect density is effectively reduced for the perovskite film to demonstrate suppressed carrier recombination and enhanced carrier extraction.Subsequently,the solar cell efficiency is elevated from 21.29%to 23.58%with negligible J-V hysteresis.Long-term stability is also improved,with the bare device without any encapsulation retaining 84%of its initial efficiency after aging 744 hours in ambient. | Xuejiao Zuo Yiyang He Hongyu Ji Yong Li Xiuying Yang Binxun Yu Tao Wang Zhike Liu Wenliang Huang Jing Gou Ningyi Yuan Jianning Ding Shengzhong Frank Liu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 16 | PlantscRNAdb: A database for plant single-cell RNA analysis显示文摘Dear Editor,Many functional characteristics of plant tissue attribute to highly specialized cells in the tissue.Dissecting cell types and profiling the transcriptome and proteome of individual cell types of plant tissues are important for understanding cellular activities underlying plant development and stress adaptation(Shaw et al.,2021).Single-cell RNA sequencing(scRNA-seq)provides such a tool for studying the transcriptional activities of individual cell types at single-cell resolution in any given organism(Rich-Griffin et al.,2020). | Hongyu Chen Xinxin Yin Longbiao Guo Jie Yao Yiwen Ding Xiaoxu Xu Lu Liu Qian-Hao Zhu Qinjie Chu Longjiang Fan | 2021 | Molecular Plant2021，14，6： | 1 |
| 17 | Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis显示文摘 | Jinxu Zhou Tao Xu Rong Qin Yong Yan Chao Chen Yuanyuan Chen Hongyu Yu Chunyan Xia Yicheng Lu Xuehua Ding Yuhai Wang Xuejian Cai Juxiang Chen | 2012 | Journal of Neuro-Oncology2012，，2： | 1 |
| 18 | Influence of average molecular weight on antioxidant and functional properties of cartilage collagen hydrolysates from Sphyrna lewini , Dasyatis akjei and Raja porosa显示文摘 | Zhongrui Li Bin Wang Changfeng Chi Yandan Gong Hongyu Luo Guofang Ding | 2012 | Food Research International2012，，： | 1 |
| 19 | Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis显示文摘 | Jinxu Zhou Tao Xu Rong Qin Yong Yan Chao Chen Yuanyuan Chen Hongyu Yu Chunyan Xia Yicheng Lu Xuehua Ding Yuhai Wang Xuejian Cai Juxiang Chen | 2012 | Journal of Neuro-Oncology2012，，2： | 1 |
| 20 | A bi-functional strategy involving surface coating and subsurface gradient co-doping for enhanced cycle stability of LiCoO_(2) at 4.6 V显示文摘Layered LiCoO_(2)(LCO)acts as a dominant cathode material for lithium-ion batteries(LIBs)in 3C products because of its high compacted density and volumetric energy density.Although improving the high cutoff voltage is an effective strategy to increase its capacity,such behavior would trigger rapid capacity decay due to the surface or/and structure degradation.Herein,we propose a bi-functional surface strategy involving constructing a robust spinel-like phase coating layer with great integrity and compatibility to LiCoO_(2) and modulating crystal lattice by anion and cation gradient co-doping at the subsurface.As a result,the modified LiCoO_(2)(AFM-LCO)shows a capacity retention of 80.9%after 500 cycles between 3.0and 4.6 V.The Al,F,Mg enriched spinel-like phase coating layer serves as a robust physical barrier to effectively inhibit the undesired side reactions between the electrolyte and the cathode.Meanwhile,the Al,F,Mg gradient co-doping significantly enhances the surficial structure stability,suppresses Co dissolution and oxygen release,providing a stable path for Li-ions mobility all through the long-term cycles.Thus,the surface bi-functional strategy is an effective method to synergistically improve the electrochemical performances of LCO at a high cut-off voltage of 4.6 V. | Yun He Xiaoliang Ding Tao Cheng Hongyu Cheng Meng Liu Zhijie Feng Yijia Huang Menghan Ge Yingchun Lyu Bingkun Guo | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
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