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	题名	作者	年代	出处	被引量
1	Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption.	Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe	2015	Bone Research2015，3，4：	2
2	Genome remodelling in a basal-like breast cancer metastasis and xenograft显示文摘	Ding L Ellis MJ Li S Larson DE	2010	Nature2010，464，7291：	1
3	DNMT3A mutations in acute myeloid leukemia显示文摘	Ley TJ Ding L Walter MJ	2010	N Engl J Med2010，363，25：	1
4	Recurrent DNMT3A mutations in patients with myelodysplastic syndromes 显示文摘	Walter MJ Ding L Shen D	2011	Leukemia2011，25，7：	1
5	Recurrent DAMT3A mutations in patients with myelodysplastic syndromes 显示文摘	Walter MJ Ding L Shen D	2011	Leukemia2011，25，7：	1
6	Hematopoietic sys- tem responses of ionization radiation exposure 显示文摘	Zhou MJ Zheng L Ding ZH	2004	Foreign Med Sci Sec Radiat Med Nucl Med2004，28，3：	1
7	Angiopoietin-like 4 protein elevates the prosurvival intracellular O2 -:H2O2 ratio and confers anoikis resistance to tumors显示文摘	Zhu P Tan MJ Huang RL Tan CK Chong HC Pal M Lam CR Boukamp P Pan JY Tan SH Kersten S Li HY Ding JL Tan NS		0，，03：	1
8	Functions of autophagy in normal and diseased liver显示文摘	Czaja MJ Ding WX Donohue TM Jr		0，，：	1
9	DNMT3A mutations in acute myeloid leukemia显示文摘	Ley TJ Ding L Walter MJ	2010	N Engl J Med2010，363，：	1
10	DNMT3A mutations in acute myeloid leukemia显示文摘	Ley TJ Ding L Walter MJ	2010	N Engl J Med2010，363，25：	1
11	Differentiation of primarychordoma,giant cell tumorand schwannoma of the sacrumby CT and MRI 显示文摘	Si MJ Wang CS Ding XY	2013	EurJ Radiol2013，82，12：	1
12	DNMT3A mutations in acute myeloid leukemia显示文摘	LEY TJ DING L WALTER MJ	2010	N Engl J Med2010，363，25：	1
13	Functions of autophagy in normal and diseased liver显示文摘	Czaja MJ Ding WX Donohue TM Jr	2013	Autophagy2013，9，8：	1
14	Functions of autophagy in normal and diseased liver显示文摘	Czaja MJ Ding WX Donohue TM Jr	2013	Autophagy2013，9，8：	1
15	Separation and analysis of aromatic hydrocarbons from two Chinese coals显示文摘	DING MJ LI W D XIE R L ZONG Y CAl K Y PENG Y L ZONG Z M WEI X Y	2008	J China Univ Min Technol2008，18，43：	1
16	Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-κB显示文摘	Wu MJ Wang L Ding HY	2004	J Biomed Sci2004，11，2：	1
17	Recurrent DNMT3A mutations in patients with myelodysplastic syndromes显示文摘	Walter MJ Ding L Shen D	2011	Leukemia2011，25，7：	1
18	Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy显示文摘	Wijnhoven TJ van den Hoven MJ Ding H	2008	Diabetologia2008，51，2：	1
19	Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma显示文摘	Ding Y Shimada Y Gorrin-Rivas MJ	2002	Oncology2002，63，4：	1
20	Genome remodelling in a basal-like breast cancer metastasis and xenograft 显示文摘	Ding L Ellis MJ Li S	2010	Nature2010，464，7291：	1

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