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| 1 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 2 | Prognostic value of CA 19-9, CEA, CRP, LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer: results from a multicenter, pooled analysis of patients receiving palliative chemotherapy显示文摘 | Michael Haas Volker Heinemann Frank Kullmann Rüdiger P. Laubender Christina Klose Christiane J. Bruns Stefan Holdenrieder Dominik P. Modest Christoph Schulz Stefan Boeck | 2013 | Journal of Cancer Research and Clinical Oncology2013，，4： | 4 |
| 3 | KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer显示文摘 | Stefan Boeck Andreas Jung Rüdiger P. Laubender Jens Neumann Rosalind Egg Clara Goritschan Steffen Ormanns Michael Haas Dominik P. Modest Thomas Kirchner Volker Heinemann | 2013 | Journal of Gastroenterology2013，，4： | 2 |
| 4 | Analysis of the immunological microenvironment at the tumor site in patients with non-small cell lung cancer显示文摘 | Rui Li Dominik Rüttinger Rong Li Lü-Sheng Si Yi-Li Wang | 2003 | Langenbeck’s Archives of Surgery2003，，6： | 1 |
| 5 | Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer显示文摘 | Dominik R Haudens C Sahrina M | 2004 | Cancer Res2004，64，22： | 1 |
| 6 | Programme zur simulation von auflaufvorgangen mit beliebigen puffern显示文摘 | Reich O Dominik R | 1992 | ZEV-Glas1992，116，1112： | 1 |
| 7 | Virus Dynamics: the Effect of Target Cell Limitation and Immune Response on Virus Evolution 显示文摘 | Roland R Regoes Dominik Wodarz Martin A Nowak | 1998 | J Theor Biol1998，191，： | 1 |
| 8 | Variable reliability of endoscopic findings with white-light and narrow-brand imaging for patients with suspected eosinophilic esophagitis 显示文摘 | Peery AF Cao H Dominik R | 2011 | Clin Gastroenterol Hepatol2011，9，8： | 1 |
| 9 | New observa- tions with the gas electron multiplier(GEM) 显示文摘 | Bouclier R Dominik W Hoch M | 1997 | Nu- clear Instruments and Methods in Physics Research A1997，396，12： | 1 |
| 10 | Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma显示文摘 | Claus Sch?fer Hendrik Seeliger Dominik C. Bader Gerald Assmann Denise Buchner Yang Guo Andreas Ziesch Andreas Palagyi Stephanie Ochs Rüdiger P. Laubender Andreas Jung Enrico N. De Toni Thomas Kirchner Burkhard G?ke Christiane Bruns Eike Gallmeier | 2012 | Journal of Cellular and Molecular Medicine2012，，8： | 1 |
| 11 | Galectin-3Expression in normal,hyperplastic,and neoplastic endometrial Tissues显示文摘 | HERMANN B DOMINIK R SUSANNA N | 2003 | Pathol Res2003，199，3： | 1 |
| 12 | Application of nontraditional stable-isotope systems to the study of sources and fate of metals in the environment显示文摘 | Dominik J W Mark R Ronny S | 2008 | Environmental Science & Technology2008，42，3： | 1 |
| 13 | Regression of bone metastases following adoptive transfer of anti-CD3-activated and IL-2-expanded tumor vaccine draining lymph node cells显示文摘 | Dominik Rüttinger Rui Li Walter J. Urba Bernard A. Fox Hong-Ming Hu | 2004 | Clinical and Experimental Metastasis2004，，4： | 1 |
| 14 | Multipath curved planar reformation of the peripheral arterial tree in CT angiography显示文摘 | Justns E R Dominik F Arnold K | 2007 | Radiology2007，244，1： | 1 |
| 15 | Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial显示文摘 | Jürgen Finke Wolfgang A Bethge Claudia Schmoor Hellmut D Ottinger Matthias Stelljes Axel R Zander Liisa Volin Tapani Ruutu Dominik A Heim Rainer Schwerdtfeger Karin Kolbe Jiri Mayer Johan A Maertens Werner Linkesch Ernst Holler Vladimir Koza Martin Bornh? | 2009 | Lancet Oncology2009，，9： | 1 |
| 16 | DynamicCausalModelingofSpontaneousDluctuationsinSkinConductance显示文摘 | Dominik R Bach Jean Daunizeau Nadine Kueklzow | 2011 | Psychophysiology2011，48，25： | 1 |
| 17 | Galectin-3 Expression in Normal, Hyperplastic, and Neoplastic Endometrial Tissues 显示文摘 | Hermann B Dominik R Susanna N | 2003 | Pathol Res2003，199，3： | 1 |
| 18 | An integrated computerized tri- age system in the emergency department 显示文摘 | Dominik A lan J Bill R | 2008 | AMIA Annu Symp Proc2008，2008，： | 1 |
| 19 | Acute abdomen caused by a perforated inflammatory myofibroblastic tumor of the jejunum 显示文摘 | Dominik H Charles R Marco N | 2006 | Int Surg2006，91，1： | 1 |
| 20 | A Multipathogen Bile Sample-based PCR Assay Can Guide Empirical Antimicrobial Strategies in Cholestatic Liver Diseases显示文摘Background and objectives:Polymerase chain reaction(PCR)techniques provide rapid detection of pathogens.This pilot study evaluated the diagnostic utility and clinical impact of multiplex real-time PCR(mRT-PCR,SeptiFast)vs.conventional microbial culture(CMC)in bile samples of patients with chronic cholestatic liver diseases(cCLDs),endoscopic retrograde cholangio-pancreatography(ERCP),and peri-interventional-antimicrobial-prophylaxis(pAP).Methods:We prospectively collected bile samples from 26 patients for microbiological analysis by CMC and mRT-PCR.Concordance of the results of both methods was determined by Krippendorff's alpha(α)for inter-rater reliability and the Jaccard index of similarity.Results:mRT-PCR_(bile)and CMC_(bile)results were concordant for only Candida albicans(α=0.8406;Jaccard index=0.8181).mRT-PCR_(bile)detected pathogens in 8/8 cases(100%),CMC_(bile)in 7/8(87.5%),and CMCblood in 5/8(62.5%)with clinical signs of infection.mRTPCR_(bile),CMC_(bile),and CMCblood had identical detection results in 3/8(37.5%)with clinical signs of infection(two Klebsiella spp.and one Enterococcus faecium).The total pathogen count was significantly higher with mRT-PCR_(bile)than with CMC_(bile)(62 vs.31;χ^(2)=30.031,p<0.001).However,pathogens detected by mRT-PCR_(bile)were more often susceptible to pAP according to the patient infection/colonization history(PI/CH)and surveillance data for antibiotic resistance in our clinic(DARC).Pathogens identified by mRT-PC_(Rbile)and resistant to pAP by PI/CH and DARC were likely to be clinically relevant.Conclusions:mRT-PCR in conjunction with CMCs for bile analysis increased diagnostic sensitivity and may benefit infection management in patients with cholestatic diseases.Implementation of mRT-PCR in a bile sample-based diagnostic routine can support more rapid and targeted use of antimicrobial agents in cCLD-patients undergoing ERCP and reduce the rate/length of unnecessary administration of broad-spectrum antibiotics. | Michael Jahn Mustafa KÖzçürümez Sebastian Dolff Hana Rohn Dominik Heider Alexander Dechêne Ali Canbay Peter M.Rath Antonios Katsounas | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
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