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| 1 | Efficacy and safety of vitamin D3 in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials显示文摘 | Zhao Junyu Dong Jianjun Wang Haipeng Shang Hongxia Zhang Dongmei Liao Lin | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 2 | Genetic Polymorphisms in the Precursor MicroRNA Flanking Region and Non-Small Cell Lung Cancer Survival显示文摘 | Hu, Zhibin Shu, Yongqian Chen, Yijiang Chen, Jiaping Dong, Jing Liu, Yao Pan, Shiyang Xu, Lin Xu, Jing Wang, Yi Dai , Juncheng Ma, Hongxia Jin, Guangfu Shen,Hongbing | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 8 |
| 3 | Ultrabithorax is a key regulator for the dimorphism of wings,a main cause for the outbreak of planthoppers in rice显示文摘Rice planthoppers,the most devastating rice pests,occur in two wing forms:the short-wing form for rapid population growth and long-wing form for long-distance migration,which together create the mechanism for outbreak.Here we show that Ultrabithorax(Ubx)is a key regulator for switching between the long-and short-wing forms of rice planthoppers.Ubx is expressed in both forewing and hindwing pads,which is different from the canonical model of Ubx expression.In brown planthoppers,expression of Ubx(Nl Ubx)is regulated by nutritional status of the rice host.High-quality young plants induce Nl Ubx expression leading to the short-wing form;low-quality ripe plants reduce Nl Ubx expression resulting in long-wing form.We also showed that Nl Ubx is regulated by the insulin receptors Nl In R1 and Nl In R2.The default expression of Nl In R1 inhibits Nl Ubx resulting in long-wings,while high-quality hosts induce Nl In R2 expression,which represses Nl In R1 thus promoting Nl Ubx expression to produce short-wings. | Fangzhou Liu Xiang Li Muhua Zhao Mengjian Guo Kehong Han Xinxin Dong Jing Zhao Wanlun Cai Qifa Zhang Hongxia Hua | 2020 | National Science Review2020，7，7： | 5 |
| 4 | Progress of Chinese research in physical oceanography of the Southern Ocean显示文摘Oceanographic surveying has been one of the key missions of the Chinese National Antarctic Research Expedition since 1984. Using the field data obtained in these surveys and the results from remote sensing and numerical models, Chinese physical oceanographers have investigated the water masses, fronts and circulation patterns in the Southern Ocean. The results of nearly 30 years of research are summarized in this paper. Most oceanographic observations by Chinese researchers have been conducted in Prydz Bay and the adjacent seas. CTD (Conductivity Temperature and Depth) data, collected during the past 20 years, have been applied to study several features of the water masses in this region: The spatial variation of warm summer surface water, the northward extension of shelf water, the flow of ice shelf water from the cavity beneath the Amery Ice Shelf, the upwelling of the Circumpolar Deep Water, and the formation of the Antarctic Bottom Water. The circulation and its dynamic factors have been analyzed with dynamic heights calculated from CTD data as well as by numerical models. The structure and strength of the fronts in the southeast Indian Ocean and the Drake Passage were investigated with underway XBT/XCTD (Expendable Bathythermograph/Expendable CTD) and ADCP (Acoustic Doppler Current Profiler) data. Their interannual variations have been determined and the factors of influence, especially the atmospheric forcing and mesoscale oceanic processes, were studied using remote sensing data. The dynamic mechanism of the Antarctic Circumpolar Current (ACC) was analyzed by theoretical models. The transport and pattern of the ACC have been well reproduced by coupled sea ice-ocean models. Additional details of ACC variability were identified based on satellite altimeter data. The response of the ACC to climate change was studied using reanalysis data. Prospects for future research are presented at the end of this paper. | SHI Jiuxin DONG Zhaoqian CHEN Hongxia | 2013 | Advances in Polar Science2013，24，2： | 5 |
| 5 | Effect of Jianpiyiqi granule on ocular myasthenia gravis in children prepared with a formula from Traditional Chinese Medicine显示文摘OBJECTIVE: To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine(TCM) formula, on the ocular type of myasthenia gravis(MG) caused by a defect in synaptic transmission at the neuromuscular junction.METHODS: A total of 155 children with ocular MG were recruited from January 2008 to January 2015.All individuals received ineffective glucocorticoid treatment prior to admission, and were given Jianpiyiqi granules(two doses per day) for 12 months.Plasma levels of acetylcholine receptor autoantibodies(ACh R-Ab), cytokines, immune parameters and clinical score were analyzed.RESULTS: After intervention with Jianpiyiqi granule for 12 months, the levels of cytokines [including interleukin(IL)-6, IL-12, IL-17], immune parameters[including immunoglobulin G(Ig G), Ig M, free triiodothyronine, free thyroxine] and ACh R-Ab were sig-nificantly decreased(P = 0.042, P = 0.049, P = 0.011,P = 0.02, P = 0.04, P = 0.03, P = 0.01; F = 21.60, P =0.000). In contrast, IL-4 levels were significantly increased(P = 0.049). The absolute clinical score after treatment declined significantly compared with before treatment(F = 33.24, P = 0.000). The effective cure rate and the total effective rate gradually increased to a maximum of 149(96.2%) and 151(97.4%) in MG patients after 12 months of treatment, respectively.CONCLUSION: The Jianpiyiqi granule treatment lowered ACh R-Ab levels and improved cytokine and other immune parameter levels, which suggests that the granule could be an ancillary treatment for ocular MG in children caused by a defect in synaptic transmission at the neuromuscular junction. | Qi Guoyan Liu Peng Gu Shanshan Yang Hongxia Dong Huimin Xue Yinping | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 4 |
| 6 | Marine hydrographic spatial-variability and its cause at the northern margin of the Amery Ice Shelf显示文摘Conductivity,temperature and depth(CTD) data collected along a zonal hydrographic section from the northern margin of the Amery Ice Shelf on 25-27 February 2008 by the 24th Chinese National Antarctic Research Expedition (CHINARE) cruise in the 2007/2008 austral summer are analyzed to study thermohaline structures.Analysis reveals warm subsurface water in a limited area around the east end of the northern margin,where the temperature,salinity and density have east-west gradients in the surface layer of the hydrographic section.The localization of the warm subsurface water and the causes of the CTD gradients in the surface layer are discussed.In addition,the results from these CTD data analyses are compared with those from the 22nd CHINARE cruise in the 2005/2006 austral summer.This comparison revealed that the thermoclines and haloclines had deepened and their strengths weakened in the 2007/2008 austral summer.The difference between the two data sets and the cause for it can be reasonably explained and attributed to the change in ocean-ice-atmosphere interactions at the northern margin of the Amery Ice Shelf. | GE RenFeng DONG ZhaoQian CHEN HongXia LIU Na SHI JiuXing PU ShuZhen | 2011 | Advances in Polar Science2011，22，2： | 3 |
| 7 | Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women显示文摘Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility. | Meiqun Jia Lulu Ren Lingmin Hu Hongxia Ma Guangfu Jin Dake Li Ni Li Zhibin Hu Dong Hang | 2019 | The Journal of Biomedical Research2019，33，5： | 2 |
| 8 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 9 | Precision casting of Ti-15V-3Cr-3Al-3Sn alloy setting显示文摘In this research, Ti-15V-3Cr-3Al-3Sn alloy ingots were prepared using ceramic mold and centrifugalcasting. The Ti-15V-3Cr-3Al-3Sn setting casting, for aeronautic engine, with 1.5 mm in thickness was manufactured.The alloy melting process, precision casting process, and problems in casting application were discussed. Effects ofHot Isostatic Pressing and heat treatment on the mechanical properties and microstructure of the Ti-15V-3Cr-3Al-3Sn alloy were studied. | Nan Hai Liu Changkui Huang Dong Zhao Jiaqi Zhao Hongxia | 2008 | China Foundry2008，5，1： | 2 |
| 10 | Thermal Insulation Materials of Alumina Based Porous Ceramics显示文摘Significant energy saving effects can be made through the improvement of furnace refractories,especially the thermal insulation refractories. In this study,the preparation and the application of different alumina based porous ceramics were briefly introduced. Alumina based porous ceramics were prepared combined foaming method with gelcasting,sol- gel process or cement curing process. The influences of different preparation methods on the sintering shrinkage, porosity, phase composition, microstructure, compressive strength and thermal conductivity were discussed. Alumina based porous ceramics with relatively high strength and low thermal conductivity could be obtained through the above mentioned methods. Compared with the traditional lining materials,about 40% energy could be saved when they were used as the furnace wall. | YUAN Bo CHEN Kuo HAN Jianshen DONG Binbin WANG Gang LI Hongxia | 2015 | China's Refractories2015，24，3： | 2 |
| 11 | Methylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer显示文摘 | Kaipeng Xie Jibin Liu Jiaping Chen Jing Dong Hongxia Ma Yao Liu Zhibin Hu | 2014 | Gene2014，，1： | 1 |
| 12 | GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependentmanner显示文摘 | Juan Ren Hui Guo Huili Wu Tao Tian Danfeng Dong Yuelang Zhang Yanxia Sui Yong Zhang Dongli Zhao Shufeng Wang Zongfang Li Xiaozhi Zhang Rui Liu Jianshneg Qian Hongxia Wei Wenjun Jiang Ya Liu Yi Li | 2015 | Oncology Reports2015，，： | 1 |
| 13 | Identification and Phylogenetic Analysis of the POLYGALACTURONASE Gene Family in Apple显示文摘In this study, a total of 85 apple polygalacturonase genes were characterized and clustered into seven groups based on the Malus × domestica whole-genome sequence. These genes coded for proteins containing 176–1 125 amino acids with isoelectric points ranging from 4.68 to 9.58.The predicted Md PG genes were distributed on all chromosomes except the 14 th. We then systematically analyzed conserved Md PG protein motifs and the structures of Md PG genes. We identified Md PG proteins containing four conserved motifs that are widely found in different PG proteins.Additionally, we found that Md PG75 was the largest gene, encompassing 18 exons. Finally, we systematically analyzed the functional connection network of Md PG proteins and predicted the functions of related Md PG genes before undertaking a preliminary validation. Overall, we have described the genome-wide identification and analysis of the apple PG gene family. | CHEN Hongfei SHAO Hongxia FAN Sheng MA Juanjuan ZHANG Dong HAN Mingyu | 2016 | Horticultural Plant Journal2016，2，5： | 1 |
| 14 | Effects of acupoint versus non-acupoint electroacupuncture on cerebral cortical neuronal Bcl-2, Bax and caspase-3 expression in a rat model of focal cerebral ischemia显示文摘BACKGROUND: Several studies have demonstrated that electroacupuncture by acupoint selection can inhibit cerebral cortical neuronal apoptosis following cerebral ischemia/reperfusion. OBJECTIVE: To validate the effects of electroacupuncture by acupoint selection on the expression level of cortical neuronal anti-apoptotic Bcl-2 protein and the apoptotic executive protein, caspase-3, in rat models of focal cerebral ischemia/reperfusion. DESIGN, TIME AND SETTING: This randomized grouping, neural cell and molecular biology animal experiment was performed at the Laboratory of Pharmacology of Traditional Chinese Medicine and the Laboratory Animal Center of Henan Institute of Traditional Chinese Medicine between November 2006 and May 2007. MATERIALS: Atotal of 40 healthy male adult Sprague-Dawley rats were randomly and evenly divided into four groups: sham-operated, model, electroacupuncture and non-acupoint control. G6895 electro-acupuncture instruments were purchased from Shanghai Huayi Instrument Factory, China. Caspase-3, Bcl-2 and Bax kits were provided by Wuhan Boster Bioengineering Co., Ltd., China. METHODS: Middle cerebral artery occlusion was induced in the model, electroacupuncture and non-acupoint groups. In the electroacupuncture group, the acupoints Jianyu (LI15), Waiguan (SJ5), Biguan (ST31), and Zusanli (ST36) were given electroacupuncture. In the non-acupoint control group, at each time point (immediately after ischemia and after reperfusion, or 2 hours after reperfusion), electroacupuncture was performed at the midpoints of Tianquan (PC2)-Quze (PC 3) line, Quze (PC 3)-Ximen (PC4) line, Zuwuli (LR10)-Yinbao (LR9) line, and Xiguan (LR7)-Zhongdu (LR6) line. Electroacupuncture parameters were set with a continuous wave with a frequency of 10 Hz, wave width 0.6 ms, voltage 1.5–3.0 V, and a duration of 10 minutes. The sham-operated and model groups received only animal fixation without electroacupuncture procedure. MAIN OUTCOME MEASURES: Five rats were selected from each group for specimen preparation. A brain tissue block comprising the frontal lobe and the occipital lobe was cut into five coronal sections of equal-thickness. Neuronal apoptosis was detected by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling technique. Expression levels of caspase-3, Bcl-2 and Bax were evaluated by immunohistochemistry. RESULTS: Compared with the sham-operated group, the model group exhibited significantly decreased Bcl-2 expression (P < 0.01), and significantly increased Bax protein expression, number of apoptotic cells, and caspase-3 expression (P < 0.01). In the electroacupuncture group, Bcl-2 protein expression was significantly increased (P < 0.01) compared with the model group, and the Bax protein expression, number of apoptotic cells, and caspase-3 expression were significantly decreased (P < 0.01); the above-mentioned changes were not significant in the non-acupoint group compared with the model group ( P > 0.05). CONCLUSION: Electroacupuncture by acpoint selection can up-regulate Bcl-2 expression and concomitantly inhibit caspase-3 and Bax expression, inhibiting neuronal poptosis in rat cerebral cortex following cerebral ischemia/reperfusion. | Jun Wang Junming Fan Yongshu Dong Xia Huang Hongxia Zhang | 2008 | Neural Regeneration Research2008，3，12： | 1 |
| 15 | Estimation of Postmortem Interval by Postmortem Myocardial Computed Tomography Value显示文摘Background:The estimation of postmortem interval(PMI)is one of the most important topics in forensic medicine research.We speculate that with an increased PMI,the computed tomography(CT)values of different tissues may show regular changes.Purpose:To use postmortem computed tomography(PMCT)to measure the myocardial CT value(unit:Hounsfield Unit,HU)of the heart to explore its pattern in postmortem change,and to discuss whether it can serve as a new parameter for PMI estimation.Methods:A total of 10 healthy adult New Zealand rabbits were selected and then put into a 20℃ incubator after being sacrificed.Within 0-156 h after death,CT scans were performed every 12 h to detect changes in the myocardial CT value of the heart over time.Regression analysis was used to determine the relationship between the myocardial CT value of the heart and PMI.At the same time,HE and Masson were used to stain the cardiac tissue sections detected by PMCT at Oh,48h and 156h,respectively.Results:During 0-156 h,the overall myocardial CT value showed a trend of first rising and then decreasing with the increase of PMI.The fitting regression equation was y=-2873.193+143.866x-1.728x2(x:myocardial CT value,unit:Hu;y:PMI,unit:h,R2=0.466,P<0.05).During 48-156 h,the overall myocardial CT value decreased gradually with the increase of PMI.The fitting regression equation was y=-93.038+18.700x-0.321x2(x:myocardial CT value,unit:Hu;y:PMI,unit:h,R2=0.963,P<0.001).The results of the morphological changes of the myocardial tissue structure after death showed that the myocardial cell structure was relatively complete at 0-48 hours after death;and the myocardial cell structure disappeared at 156 hours after death.Conclusions:Our results revealed evident postmortem changes in the myocardial CT value of the heart.Accordingly,measuring the myocardial CT value through PMCT shows promise for being used as a parameter for PMI estimation in forensic medicine and is worthy of further studies.The morphological changes of the myocardial tissue structure after death provide morphological basis for postmortem changes of tissue density,and further prove the reasons for the changes of CT value. | Zhiyuan An Hongxia He Qing Niu Haibiao Zhu Yucong Wang Ran Liu Weiliang Hou Peng Tang Tiantong Yang Dong Zhao | 2021 | Journal of Forensic Science and Medicine2021，7，3： | 1 |
| 16 | Preparation and characteristics of Fe 3 O 4 @YVO 4 :Eu 3+ bifunctional magnetic–luminescent nanocomposites显示文摘 | Hongxia Peng Guixia Liu Xiangting Dong Jinxian Wang Jia Xu Wensheng Yu | 2011 | Journal of Alloys and Compounds2011，，24： | 1 |
| 17 | Overexpression of TaPIEP1, a pathogen-induced ERF gene of wheat, confers host-enhanced resistance to fungal pathogen Bipolaris sorokiniana显示文摘 | Na Dong Xin Liu Yan Lu LiPu Du Huijun Xu Hongxia Liu Zhiyong Xin Zengyan Zhang | | 0，2010，： | 1 |
| 18 | China renewable energy development evaluation and structure optimiza- tion显示文摘 | Li Hong Dong Liang Duan Hongxia | 2011 | Resource Science2011，，33： | 1 |
| 19 | Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver显示文摘 | Hongxia Wang Kun Dong Xiaowei Xue Ping Feng Xuejiang Wang | 2010 | Peptides2010，，2： | 1 |
| 20 | A modified NaSch model with density-dependent randomization for traffic flow显示文摘 | Zhu Huibing Ge Hongxia Dong Liyun | 2007 | Eur Phys J B2007，57，： | 1 |
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