|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genotyping-by-sequencing application on diploid rose and a resulting high-density SNP-based consensus map显示文摘Roses,which have been cultivated for at least 5000 years,are one of the most important ornamental crops in the world.Because of the interspecific nature and high heterozygosity in commercial roses,the genetic resources available for rose are limited.To effectively identify markers associated with QTL controlling important traits,such as disease resistance,abundant markers along the genome and careful phenotyping are required.Utilizing genotyping by sequencing technology and the strawberry genome(Fragaria vesca v2.0.a1)as a reference,we generated thousands of informative single nucleotide polymorphism(SNP)markers.These SNPs along with known bridge simple sequence repeat(SSR)markers allowed us to create the first high-density integrated consensus map for diploid roses.Individual maps were first created for populations J06-20-14-3דLittle Chief”(J14-3×LC),J06-20-14-3דVineyard Song”(J14-3×VS)and“Old Blush”דRed Fairy”(OB×RF)and these maps were linked with 824 SNPs and 13 SSR bridge markers.The anchor SSR markers were used to determine the numbering of the rose linkage groups.The diploid consensus map has seven linkage groups(LGs),a total length of 892.2 cM,and an average distance of 0.25 cM between 3527 markers.By combining three individual populations,the marker density and the reliability of the marker order in the consensus map was improved over a single population map.Extensive synteny between the strawberry and diploid rose genomes was observed.This consensus map will serve as the tool for the discovery of marker–trait associations in rose breeding using pedigree-based analysis.The high level of conservation observed between the strawberry and rose genomes will help further comparative studies within the Rosaceae family and may aid in the identification of candidate genes within QTL regions. | Muqing Yan David H.Byrne Patricia E.Klein Jizhou Yang Qianni Dong Natalie Anderson | 2018 | Horticulture Research2018，5，1： | 6 |
| 2 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 3 | Gas chromatography - mass spectrometry of carbonyl compounds in cigarette mainstream smoke after derivatization with 2, 4-dinitrophenylhydt-a-zine 显示文摘 | DONG Jizhou MOLDOYEANU S | 2004 | J Chromatogr : A2004，1027，： | 1 |
| 4 | Gas chromato graphy-mass spectrometry of carbonyl compounds in cigarette mainstream smoke after derivatization with 2, 4-dinitrophenylhydrazine 显示文摘 | Dong Jizhou Serban C Moldoveanu | 2004 | J Chromatogr A2004，1027，： | 1 |
| 5 | Facile fabrication of self-healing silicone-based poly(urea-thiourea)/tannic acid composite for anti-biofouling显示文摘A novel silicone-based poly(urea-thiourea)/tannic acid composite(PDMS-P(Ua-TUa)-TA)with excellent mechanical,self-healing and antifouling properties is developed.The multiple dynamic hydrogen bonds formed by thiourea groups,urea groups,and tannic acid(TA)molecules ensured a tough elastomer(ultimate strength:2.47 MPa)with high stretchability(~1000%).TA molecules as partial hydrogen bonding cross-linking sites interacted rapidly with urea and thiourea groups before the migration of polymer chains,resulting in fast and efficient self-healing.Scratches on the film completely disappeared within12 min,and the repair efficiency of strength was up to 98.4%within 3 h under ambient condition.Selfhealing behavior was also evaluated in artificial seawater and the healing efficiency(HE)was 95.1%.Furthermore,TA uniformly dispersed in the polymer matrix provides good antibacterial and anti-diatom properties,as well as strong adhesion to the substrate(~2.2 MPa).Laboratory bioassays against marine bacteria adhesion(~96%,~95%and~93%reduction for P.sp.,E.coli,and S.aureus,respectively)and diatom attachment(~84%reduction)demonstrated an outstanding antifouling property of the PDMSP(Ua-TUa)-TA.This work provides a promising pathway towards the development of high-performance silicone-based coatings for marine anti-biofouling. | Jiawen Sun Chao Liu Jizhou Duan Jie Liu Xucheng Dong Yimeng Zhang Ning Wang Jing Wang Baorong Hou | 2022 | Journal of Materials Science & Technology2022，，29： | 1 |
| 6 | A simple GC-MS technique for the analysis of vapor phase mainstream cigarette smoke 显示文摘 | DONG Jizhou Glass J N Moldoveanu S C | 2000 | Microcolumn Separations2000，12，3： | 1 |
| 7 | Green synthesis of functional metallic nanoparticles by dissimilatory metal-reducing bacteria“Shewanella”:A comprehensive review显示文摘The biosynthesis strategy of nanoparticles has attracted much attention due to the mild synthesis condi-tions,environmental-friendly properties,and low costs.Biosynthesized nanoparticles(bio-NPs)not only show excellent physicochemical properties,but also exhibit high stability,enlarged specific surface area,and excellent biocompatibility,which are crucial for industrial,agricultural,and medical fields.She-wanella,a kind of dissimilatory metal-reducing bacteria,is regarded as a typical biosynthesis-functional bacteria class with wide distribution and strong adaptability.Thus,in this paper,functional bio-NPs by Shewanella were reviewed to provide a comprehensive view of current research progress.The biosynthetic mechanisms of Shewanella are summarized as the Mtr pathway(predominant),extracellular polymeric substance-induced pathway,and enzyme/protein-induced pathway.During the biosynthesis process,bio-logical factors along with the physicochemical parameters highly influenced the properties of the resul-tant bio-NPs.Till now,bio-NPs have been applied in various fields including environmental remediation,antibacterial applications,and microbial fuel cells.However,some challenging issues of bio-NPs by She-wanella remain unsolved,such as optimizing suitable bacterial strains,intelligently controlling bio-NPs,clarifying biosynthesis mechanisms,and expanding bio-NPs applications. | Jing Yang Peng Ju Xucheng Dong Jizhou Duan Hui Xiao Xuexi Tang Xiaofan Zhai Baorong Hou | 2023 | Journal of Materials Science & Technology2023，，27： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员