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| 1 | Genotyping-by-sequencing application on diploid rose and a resulting high-density SNP-based consensus map显示文摘Roses,which have been cultivated for at least 5000 years,are one of the most important ornamental crops in the world.Because of the interspecific nature and high heterozygosity in commercial roses,the genetic resources available for rose are limited.To effectively identify markers associated with QTL controlling important traits,such as disease resistance,abundant markers along the genome and careful phenotyping are required.Utilizing genotyping by sequencing technology and the strawberry genome(Fragaria vesca v2.0.a1)as a reference,we generated thousands of informative single nucleotide polymorphism(SNP)markers.These SNPs along with known bridge simple sequence repeat(SSR)markers allowed us to create the first high-density integrated consensus map for diploid roses.Individual maps were first created for populations J06-20-14-3דLittle Chief”(J14-3×LC),J06-20-14-3דVineyard Song”(J14-3×VS)and“Old Blush”דRed Fairy”(OB×RF)and these maps were linked with 824 SNPs and 13 SSR bridge markers.The anchor SSR markers were used to determine the numbering of the rose linkage groups.The diploid consensus map has seven linkage groups(LGs),a total length of 892.2 cM,and an average distance of 0.25 cM between 3527 markers.By combining three individual populations,the marker density and the reliability of the marker order in the consensus map was improved over a single population map.Extensive synteny between the strawberry and diploid rose genomes was observed.This consensus map will serve as the tool for the discovery of marker–trait associations in rose breeding using pedigree-based analysis.The high level of conservation observed between the strawberry and rose genomes will help further comparative studies within the Rosaceae family and may aid in the identification of candidate genes within QTL regions. | Muqing Yan David H.Byrne Patricia E.Klein Jizhou Yang Qianni Dong Natalie Anderson | 2018 | Horticulture Research2018，5，1： | 6 |
| 2 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 3 | Numerical simulation of Gurney flap on SFYT15thick airfoil显示文摘A two-dimensional steady Reynolds-averaged Navier–Stokes(RANS) equation was solved to investigate the effects of a Gurney flap on SFYT15 thick airfoil aerodynamic performance. This airfoil was designed for flight vehicle operating at 20 km altitude with freestream velocity of 25 m/s. The chord length(C) is5 m and the Reynolds number based on chord length is Re = 7.76 × 105. Gurney flaps with the heights ranging from 0.25%C to 3%C were investigated. The shear stress transport(SST) k-ω turbulence model was used to simulate the flow structure around the airfoil. It is showed that Gurney flap can enhance not only the prestall lift but also lift-to-drag ratio in a certain range of angles of attack. Specially, at cruise angle of attack(α = 3°), Gurney flap with 0.5%C height can increase lift-to-drag ratio by 2.7%, and lift coefficient by 12.9%, respectively. Furthermore, the surface pressure distribution, streamlines and trailing-edge flow structure around the airfoil are illustrated, which are helpful to understand the mechanisms of Gurney flap on airfoil aerodynamic performance. Moreover, it is found that the increase of airfoil drag with Gurney flap can be attributed to the increase of pressure drag between the windward and the leeward sides of Gurney flap itself. | Xi He Jinjun Wang Muqing Yang Dongli Ma Chao Yan Peiqing Liu | 2016 | Theoretical & Applied Mechanics Letters2016，6，6： | 5 |
| 4 | A high-quality genome assembly of Morinda officinalis,a famous native southern herb in the Lingnan region of southern China显示文摘Morinda officinalis is a well-known medicinal and edible plant that is widely cultivated in the Lingnan region of southern China.Its dried roots(called bajitian in traditional Chinese medicine)are broadly used to treat various diseases,such as impotence and rheumatism.Here,we report a high-quality chromosome-scale genome assembly of M.officinalis using Nanopore single-molecule sequencing and Hi-C technology.The assembled genome size was 484.85Mb with a scaffold N50 of 40.97 Mb,and 90.77%of the assembled sequences were anchored on eleven pseudochromosomes.The genome includes 27,698 protein-coding genes,and most of the assemblies are repetitive sequences.Genome evolution analysis revealed that M.officinalis underwent core eudicotγgenome triplication events but no recent whole-genome duplication(WGD).Likewise,comparative genomic analysis showed no large-scale structural variation after species divergence between M.officinalis and Coffea canephora.Moreover,gene family analysis indicated that gene families associated with plant–pathogen interactions and sugar metabolism were significantly expanded in M.officinalis.Furthermore,we identified many candidate genes involved in the biosynthesis of major active components such as anthraquinones,iridoids and polysaccharides.In addition,we also found that the DHQS,GGPPS,TPS-Clin,TPS04,sacA,and UGDH gene families—which include the critical genes for active component biosynthesis—were expanded in M.officinalis.This study provides a valuable resource for understanding M.officinalis genome evolution and active component biosynthesis.This work will facilitate genetic improvement and molecular breeding of this commercially important plant. | Jihua Wang Shiqiang Xu Yu Mei Shike Cai Yan Gu Minyang Sun Zhan Liang Yong Xiao Muqing Zhang Shaohai Yang | 2021 | Horticulture Research2021，8，1： | 4 |
| 5 | Numerical simulation of gurney flaps lift-enhancement on a low reynolds number airfoil显示文摘Two-dimensional steady Reynolds-averaged Navier-Stokes(RANS) equations with transition shear stress transport(SST) model were solved to investigate the effects of Gurney flaps on the aerodynamic performance of a low Reynolds number airfoil. This airfoil was designed for flight vehicles operating at 20 km altitude with freestream velocity of 25 m/s. The chord length(C) of this airfoil is 5 m and the corresponding Reynolds number is 7.76×10~5. Gurney flaps with the heights ranging from 0.25%C to3%C were investigated. It has been shown that Gurney flaps can enhance not only the prestall lift but also lift-to-drag ratio in a certain range of angles of attack. Specially, at cruise angle of attack(3°), Gurney flap with the height of 0.5%C.can increase lift-to-drag ratio and lift coefficient by 1.6% and 12.8%, respectively. Furthermore, the mechanisms of Gurney flaps to improve the aerodynamic performance were illustrated by analyzing the surface pressure distribution, streamlines and trailing-edge flow structure for this low Reynolds number airfoil. Specially, distinguished from some other numerical researches, the flow details such as the laminar separation bubble and transition phenomena for low Reynolds number airfoil with Gurney flaps were investigated and it was found that Gurney flaps can delay the transition onset position at small angles of attack(≤2°). However, with the increase of angles of attack, Gurney flaps will promote the boundary layer transition. | HE Xi WANG JinJun YANG MuQing MA DongLi YAN Chao LIU PeiQing | 2017 | Science China(Technological Sciences)2017，60，10： | 3 |
| 6 | Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance显示文摘 | Muqing Zhou Zhiming Jin Yiwen Liu Yiqing He Yan Du Cuixia Yang Yingzhi Wang Jiajie Hu Lian Cui Feng Gao Manlin Cao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 7 | Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment显示文摘F1Fo-ATP synthase 原来是思维只在线粒体的内部膜定位。然而,最近的研究在房间膜的外面上证明宫外的 F1Fo-ATP synthase 的存在。宫外的 ATP synthase 为肿瘤目标治疗作为一个标记被建议。不过,宫外的 ATP synthase 的蛋白质运输机制仍然是不清楚的。关于肿瘤,因为它的普遍表示,宫外的 ATP synthase 的特性被询问。在当前的学习,我们构造了绿色荧光灯 protein-ATP5B 熔化蛋白质并且介绍了它进 HepG2 房间学习 ATP synthase 的本地化。ATP5B 的表示与不同恶意在六根房间线被分析。这些房间是有教养的在正常、像肿瘤酸并且 hypoxic 条件。结果建议 ATP synthase 的宫外的表示是从线粒体的 translocation 的后果。表示和宫外的 ATP synthase 的催化活动作为在不太恶意的房间的表面上在恶意的房间的表面上是类似的。有趣地,宫外的 ATP synthase 的表示不是起来调整的在像肿瘤酸并且 hypoxic 微型环境。然而,宫外的 ATP synthase 的催化活动在像肿瘤的微型环境是起来调整的。因此,为肿瘤目标治疗的宫外的 ATP synthase 的特性依靠被观察在的催化活动的高水平酸并且在肿瘤纸巾的 hypoxic 微型环境。 | Zhan Ma Manlin Cao Yiwen Liu Yiqing He Yingzhi Wang Cuixia Yang Wenjuan Wang Yan Du Muqing Zhou Feng Gao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 1 |
| 8 | Robust on-demand rou- ting mechanism for wireless multi- hop networks 显示文摘 | Su Jingfang Wu Muqing Zhen Yan | 2011 | IET Communications2011，5，5： | 1 |
| 9 | Speed aware self-adapting and reconfigurable routing mechanism in MANET显示文摘 | Zhang Qinjuan Wu Muqing Zhen Yan | 2012 | High Technology Letters2012，18，3： | 0 |
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