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| 1 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 2 | Novel image encryption algorithm based on multiple-parameter discrete fractional random transform显示文摘 | Zhou Nanrun Dong Taiji Wu Jianhua | | 0，，15： | 1 |
| 3 | Research on multi-parametric sensors based on multi-mode microfiber显示文摘A multi-parametric sensor based on multi-mode microfiber(MMF)is proposed,utilizing the modal interference between HE11mode and HE12mode in the elongated multi-mode fiber to achieve the temperature and pressure measurement.In this paper,the simulation model of modal interference based on MMF is established and the mechanism of modal interference is analyzed.Using the different mechanisms of modal response in the fiber at different wavelengths,the temperature was inverted using the offset of wavelengths in the spectrum,and the pressure was measured using the change of light intensity.The independent measurement of temperature and pressure was achieved.The experimental results show that the sensor has a temperature sensitivity of 1.305 nm/℃.In the case of pressure sensing,the sensor shows a sensitivity of-0.163 d Bm/g. | DONG Taiji LIU Xu WANG Yunkai GAO Bingkun JIANG Chunlei WANG Xiufang | 2024 | Optoelectronics Letters2024，20，1： | 0 |
| 4 | Current measurement method based on magneto-optic rotation effect显示文摘Aiming at the approximate measurement of magnetic rotation angle in optical current sensor based on light intensity detection mode,this paper proposes a current measurement method based on triangular constant transformation to reconstruct magnetic rotation angle,so as to avoid the large current measurement error caused by the approximate measurement of the magnetic rotation angle.By extracting the direct current(DC)component and the alternating current(AC)component of the light intensity signal detected by the photoelectric detector(PD),the sine signal containing the magnetic rotation angle is directly obtained by dividing the two components,and then the triangular identity transformation method is used to linearly demodulate the magnetic rotation angle and reconstruct the current waveform.The experimental results show that the relative error of current measurement does not exceed 1.40%in the current range of 0.05—0.50 A,which is less than the approximate linear measurement(ALM)method,and the magnetic rotation angle and the current have a good linear relationship. | SHUI Huasheng RONG Yufei JIANG Chunlei DONG Taiji | 2023 | Optoelectronics Letters2023，19，9： | 0 |
| 5 | Particle motion trajectory tracking based on fiber optic tweezers显示文摘A biosensor based on single-fiber optical tweezers is proposed,which can detect the motion trajectory of cells based on the stable capture and transmission of silica microspheres as well as biological yeast cells by using a tapered optical fiber as a sensing element.The interference cavity is formed by using the fiber tip and the target particle,the detected interference signal is demodulated using Hilbert transform,and the displacement curve of the particle is plotted to realize the particle motion trajectory tracking.This method provides potential technical support for process monitoring of targeted drug delivery in biomedicine. | ZHAO Cun DONG Taiji GAO Bingkun LIU Xu ZHANG Zihua | 2023 | Optoelectronics Letters2023，19，8： | 0 |
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