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| 1 | High power and energy generation in a Nd:YAG single-crystal fiber laser at 1834 nm显示文摘We report on a diode-end-pumped high-power and high-energy Nd:YAG single-crystal fiber laser at 1834 nm.Two 808 nm diodes injecting about 58 W pump power into the Nd:YAG fiber have generated 3.28 W continuouswave and 1.66 W Cr:ZnSe-based passively Q-switched lasers. Slope efficiencies with respect to pump powers are8.7% for the continuous-wave laser and 4.9% for the Q-switched laser. The extracted maximum pulse energy is about 266.9 μJ, and the corresponding maximum pulse peak power is 2.54 kW. These performances greatly surpass previous results regarding this specific laser emission because the laser gain medium in the form of fiber can significantly mitigate thermally induced power saturation thanks to its significantly reduced thermal lensing effect. Single-crystal fiber lasers show great potential for high average power, pulse energy, and peak power. | YAQI CAI BIN XU YUNSHAN ZHANG QINGYU TIAN XIAODONG XU QINGSONG SONG DONGZHEN LI JUN XU IVAN BUCHVAROV | 2019 | Photonics Research2019，7，2： | 2 |
| 2 | Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles显示文摘Background:Sweat glands(SGs)and hair follicles(HFs)are two important cutaneous appendages that play crucial roles in homeostatic maintenance and thermoregulation,and their interaction is involved in wound healing.SGs can be regenerated from mesenchymal stem cell-laden 3D bioprinted scaffolds,based on our previous studies,whereas regeneration of HFs could not be achieved in the same model.Due to the lack of an in vitro model,the underlying molecular mechanism of the interaction between SGs and HFs in regeneration could not be fully understood.The purpose of the present study was to establish an in vitro model of skin constructs with SGs and HFs and explore the interaction between these two appendages in regeneration.Methods:To investigate the interaction effects between SGs and HFs during their regeneration processes,a combined model was created by seeding HF spheroids on 3D printed SG scaffolds.The interaction between SG scaffolds and HF spheroids was detected using RNA expression and immunofluorescence staining.The effects of microenvironmental cues on SG and HF regeneration were analysed by altering seed cell types and plantar dermis homogenate in the scaffold.Results:According to this model,we overcame the difficulties in simultaneously inducing SG and HF regeneration and explored the interaction effects between SG scaffolds and HF spheroids.Surprisingly,HF spheroids promoted both SG and HF differentiation in SG scaffolds,while SG scaffolds promoted SG differentiation but had little effect on HF potency in HF spheroids.Specifically,microenvironmental factors(plantar dermis homogenate)in SG scaffolds effectively promoted SG and HF genesis in HF spheroids,no matter what the seed cell type in SG scaffolds was,and the promotion effects were persistent.Conclusions:Our approach elucidated a new model for SG and HF formation in vitro and provided an applicable platform to investigate the interaction between SGs and HFs in vitro.This platform might facilitate 3D skin constructs with multiple appendages and unveil the spatiotemporal molecular program of multiple appendage regeneration. | Yijie Zhang Enhejirigala Bin Yao Zhao Li Wei Song Jianjun Li Dongzhen Zhu Yuzhen Wang Xianlan Duan Xingyu Yuan Sha Huang Xiaobing Fu | 2021 | Burns & Trauma2021，9，1： | 2 |
| 3 | Modeling human hypertrophic scars with 3D preformed cellular aggregates bioprinting显示文摘The therapeutic interventions of human hypertrophic scars(HHS)remain puzzle largely due to the lack of accepted models.Current HHS models are limited by their inability to mimic native scar architecture and associated pathological microenvironments.Here,we create a 3D functional HHS model by preformed cellular aggregates(PCA)bioprinting,firstly developing bioink from scar decellularized extracellular matrix(ECM)and alginate-gelatin(Alg-Gel)hydrogel with suitable physical properties to mimic the microenvironmental factors,then pre-culturing patient-derived fibroblasts in this bioink to preform the topographic cellular aggregates for sequent printing.We confirm the cell aggregates preformed in bioink displayed well defined aligned structure and formed functional scar tissue self-organization after bioprinting,hence showing the potential of creating HHS models.Notably,these HHS models exhibit characteristics of early-stage HHS in gene and protein expression,which significantly activated signaling pathway related to inflammation and cell proliferation,and recapitulate in vivo tissue dynamics of scar forming.We also use the in vitro and in vivo models to define the clinically observed effects to treatment with concurrent anti-scarring drugs,and the data show that it can be used to evaluate the potential therapeutic target for drug testing.The ideal humanized scar models we present should prove useful for studying critical mechanisms underlying HHS and to rapidly test new drug targets and develop patient-specific optimal therapeutic strategies in the future. | Yao Bin Zhu Dongzhen Cui Xiaoli Enhe jirigala Song Wei Li Zhao Hu Tian Zhu Ping Li Jianjun Wang Yuzhen Zhang Yijie Fu Xiaobing Huang Sha | 2022 | Bioactive Materials2022，7，4： | 2 |
| 4 | Engineering hollow core-shell hetero-structure box to induce interfacial charge modulation for promoting bidirectional sulfur conversion in lithium-sulfur batteries显示文摘Severe polysulfide shuttling and sluggish sulfur redox kinetics significantly decrease sulfur utilization and cycling stability in lithium-sulfur batteries(LSBs).Herein,we develop a hollow CoO/CoP-Box core-shell heterostructure as a model and multifunctional catalyst modified on separators to induce interfacial charge modulation and expose more active sites for promoting the adsorption and catalytic conversion ability of sulfur species.Theoretical and experimental findings verify that the in-situ formed core-shell hetero-interface induces the formation of P-Co-O binding and charge redistribution to activate surface O active sites for binding lithium polysulfides(LiPSs)via strong Li-O bonding,thus strongly adsorbing with Li PSs.Meanwhile,the strong Li-O bonding weakens the competing Li-S bonding in LiPSs or Li2S adsorbed on CoO/CoP-Box surface,plus the hollow heterostructure provides abundant active sites and fast electron/Li+transfer,so reducing Li2S nucleation/dissolution activation energy.As expected,LSBs with CoO/CoP-Box modified separator and traditional sulfur/carbon black cathode display a large initial capacity of 1240 mA h g^(-1)and a long cycling stability with 300 cycles(~60.1%capacity retention)at 0.5C.Impressively,the thick sulfur cathode(sulfur loading:5.2 mg cm^(-2))displays a high initial areal capacity of 6.9 mA h cm^(-2).This work verifies a deep mechanism understanding and an effective strategy to induce interfacial charge modulation and enhance active sites for designing efficient dual-directional Li-S catalysts via engineering hollow core-shell hetero-structure. | Weiliang Zhou Xinying Wang Jiongwei Shan Liguo Yue Dongzhen Lu Li Chen Jiacheng Zhang Yunyong Li | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 5 | 3D-bioprinted microenvironments for sweat gland regeneration显示文摘The development of 3D bioprinting in recent years has provided new insights into the creation of in vitro microenvironments for promoting stem cell-based regeneration.Sweat glands(SGs)are mainly responsible for thermoregulation and are a highly differentiated organ with limited regenerative ability.Recent studies have focused on stem cell-based therapies as strategies for repairing SGs after deep dermal injury.In this review,we highlight the recent trend in 3D bioprinted native-like microenvironments and emphasize recent advances in functional SG regeneration using this technology.Furthermore,we discuss five possible regulatory mechanisms in terms of biochemical factors and structural and mechanical cues from 3D bioprinted microenvironments,as well as the most promising regulation from neighbor cells and the vascular microenvironment. | Wei Song Bin Yao Dongzhen Zhu Yijie Zhang Zhao Li Sha Huang Xiaobing Fu | 2022 | Burns & Trauma2022，10，1： | 1 |
| 6 | Ultra-thick,dense dual-encapsulated Sb anode architecture with conductively elastic networks promises potassium-ion batteries with high areal and volumetric capacities显示文摘Ultra-thick,dense alloy-type anodes are promising for achieving large areal and volumetric performance in potassium-ion batteries(PIBs),but severe volume expansion as well as sluggish ion and electron diffusion kinetics heavily impede their widespread application.Herein,we design highly dense(3.1 g cm^(-3))Ti_(3)C_(2)T_(x) MXene and graphene dual-encapsulated nano-Sb monolith architectures(HD-Sb@Ti_(3)C_(2)T_(x)-G)with high-conductivity elastic networks(1560 S m^(-1))and compact dually encapsulated structures,which exhibit a large volumetric capacity of 1780.2 mAh cm^(-3)(gravimetric capacity:565.0 mAh g^(-1)),a long-term stable lifespan of 500 cycles with 82%retention,and a large areal capacity of 8.6 mAh cm^(-2)(loading:31 mg cm^(-2))in PIBs.Using ex-situ SEM,in-situ TEM,kinetic investigations,and theoretical calculations,we reveal that the excellent areal and volumetric performance mechanism stems from the three dimensional(3D)high-conductivity elastic networks and the dualencapsulated Sb architecture of Ti_(3)C_(2)T_(x) and graphene;these effectively mitigate against volume expansion and the pulverization of Sb,offering good electrolyte penetration and rapid ionic/electronic transmission.Ti_(3)C_(2)T_(x) also decreases the Kþdiffusion energy barrier,and the ultra-thick compact electrode ensures volumetric and areal performance.These findings provide a feasible strategy for fabricating ultra-thick,dense alloy-type electrodes to achieve high areal and volumetric capacity energy storage via highly-dense,dual-encapsulated architectures with conductive elastic networks. | Zhonggang Liu Xi Liu Bingchun Wang Xinying Wang Dongzhen Lu Dijun Shen Zhefei Sun Yongchang Liu Wenli Zhang Qiaobao Zhang Yunyong Li | 2023 | eScience2023，3，6： | 0 |
| 7 | Odorant-binding protein 19 in Monochamus alternatus involved in the recognition of a volatile strongly emitted from ovipositing host pines显示文摘Monochamus alternatus is the primary carrier of pine wood nematodes,which pose a serious threat to Pinus spp.in many countries.Newly emerging M.alternatus adults feed on heathy host pines,while matured adults transfer to stressed host pines for mating and oviposition.Several odorant-binding proteins(OBPs)of M.alternatus have been proved to aid in the complex process of host location.To clarify the corresponding relations between OBPs and pine volatiles,more OBPs need to be studied.In this research,MaltOBP19 showed a specific expression in the antennae and mouthparts of M.alternatus,and it was marked in 4 types of antenna sensilla by immunolocalization.Fluorescence binding assays demonstrated the high binding affinity of MaltOBP19 with camphene and myrcene in vitro.In Y-tube olfactory experiments,M.alternatus adults were attracted by camphene and RNAi of OBP19 via microinjection significantly decreased their attraction index.Myrcene induced phobotaxis,but RNAi had no significant effect on this behavior.Further,we found that ingesting dsOBP19 produced by a bacteria-expressed system with a newly constructed vector could lead to the knockdown of MaltOBP19.These results suggest that MaltOBP19 may play a role in the process of host conversion via the recognition of camphene,which has been identified to be strongly released in stressed host pines.In addition,it is proved that knockdown of OBP can be achieved by oral administration of bacteria-expressed double-stranded RNA in M.alternatus adults,providing a new perspective in the control of M.alternatus. | Ruinan Yang Dongzhen Li Shancheng Yi Yi Wei Manqun Wang | 2024 | Insect Science2024，31，1： | 0 |
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