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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，14： | 2 |
| 4 | Recognition of staffNurse job perform- ance and achievements: staff andManager percep tions显示文摘 | Nones C S Donna B | 1999 | J Nuts Administr1999，29，1： | 1 |
| 5 | Emotion and adherence to treatment in people with asthma: An application of theemotional Stroop paradigm显示文摘 | Donna C Jessop DR Rutter | 2004 | Br J Psychology2004，95，2： | 1 |
| 6 | The relationship between structural empowerment and psychologial empowerment for nurses; A systematic review显示文摘 | JoanI JW Greta C Donna LS | 2010 | Journal of Nursing Management2010，18，： | 1 |
| 7 | Bacteremia associated with tunneled dialysis catheters:Comparison of two treatment strategies显示文摘 | Bakir T Donna C Souheil S | 2000 | Kidney Int2000，57，： | 1 |
| 8 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 9 | Baeteremia associated with tunneled dialysis catheters:Comparison of two treatment strategies显示文摘 | Bakir T Donna c Souheil s etal | 2000 | Kidney Int2000，57，： | 1 |
| 10 | Regulation of bcl-xL expression by H2O2 in cardiac myocytes 显示文摘 | Donna MV Timothy JK Angela C | 2003 | J Biol Chem2003，278，25： | 1 |
| 11 | Evidence - based nursing: past,present,and future显示文摘 | Alba Nicky C Donna C | 2000 | Evid Based Nurs2000，3，1： | 1 |
| 12 | Hectare-scale demonstration of high rate algal pinds for enhanced wastewater treatment and biofuel production显示文摘 | RUPERT C DONNA S HELENA C | | 0，，03： | 1 |
| 13 | Bacteremia associated with tunneled dialysis catheters: comparison of two treatment strategies显示文摘 | Bakir T Donna C Souheil S | 2000 | Kidney Int2000，57，： | 1 |
| 14 | Unrelated umbilical cord blood transplantation in adult patients显示文摘 | Gwynn D Long Mary Laughlin Bella Madan Joanne Kurtzberg Cristina Gasparetto Ashley Morris David Rizzieri Clayton Smith James Vredenburgh Edward C Halperin Gloria Broadwater Donna Niedzwiecki Nelson J Chao | 2003 | Biology of Blood and Marrow Transplantation2003，，： | 1 |
| 15 | Variable Antigens of Ureaplasma Urealyticum Containing Both Serovar-Specific and Serovar-Cross-Reactive Epitopes显示文摘 | Harold L W Donna K B Gail H C | 1990 | Infect Immun1990，58，11： | 1 |
| 16 | Foregut duplication cyst of the stomach 显示文摘 | Steven C Cunningham Donna E | 2006 | J Gastrointest Surg2006，10，4： | 1 |
| 17 | Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment显示文摘 | Lagadec C Vlashi E Della Donna L | 2010 | Breast Cancer Res2010，12，1： | 1 |
| 18 | Safety of adenoviral vectors: results of clinical investigations in 445 cancer patients treated with advexin? (Adenoviral p53) gene therapy显示文摘 | Louis AZ Donna C James M | 2004 | Mol ther2004，9，1： | 1 |
| 19 | Radiation-induced re- programming of breast cancer cells 显示文摘 | Lagadec C Vlashi E Della Donna L | 2012 | Stem Ceils2012，30，5： | 1 |
| 20 | Relationships of temperature and sodium chloride concentration to the survival of Vibrio parahemolyticusin broth and fish homogenate显示文摘 | Donna C Margy W | 1972 | Applied and Environmental Microbiology1972，23，2： | 1 |
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