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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Adverse effects of semen processing on human spem DNA integrity显示文摘 | Victor M Keith J Donna P | 1999 | J Urol1999，161，282： | 1 |
| 3 | Adverse effect of semen processing on human sperm DNA integrity显示文摘 | Victor M Keith J Donna P | 1999 | J Urol1999，，： | 1 |
| 4 | Developing an educated citizenry: the undergraduate public health learning outcomes project显示文摘 | DONNA J P SUSAN A CHRISTINE M P et 81 | 2013 | Public Health Reports2013，128，： | 1 |
| 5 | The Hazards of Moist Toilet Paper Allergy to the Preservative Methylchloroisothiazolinone/Methylisothiazolinone显示文摘 | Kevin H Gardner Mark D P Davis MD Donna M Richardson RN | 2010 | ARCH D ER-MATOL2010，8，： | 1 |
| 6 | A conceptual framework for incorporating cognitive principles into geographical database representation显示文摘 | Jeremy L M Donna J P | 2000 | International Journal of Geographical Information Science2000，14，： | 1 |
| 7 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 8 | Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome显示文摘 | Steven P Miller M Donna M | | 0，，： | 1 |
| 9 | Purification, redox, sensitivity and RNA binding properties of SEC1S -binding protein 2: a protein involved in selenoprotein biosynthesis显示文摘 | Copeland P R Donna M | 2001 | J Biol Chem2001，274，25： | 1 |
| 10 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 11 | Levetiracetam prophylaxis in pediatricmigraine:An open label study显示文摘 | Ann P Donna K Lisa M | 2007 | Headache2007，47，42： | 1 |
| 12 | Environmental Estrogens Alter Early Development in Xenopus laevis显示文摘 | CASSANDRA L B DONNA M P ANITA P | 2003 | Environmental Health Perspectives2003，111，4： | 1 |
| 13 | Thermal Stability of Cyclopentane as an Organic Rankine Cycle Working Fluid 显示文摘 | Daniel M G Lucia M P Donna P G | 2011 | Energy 8z Fuel2011，25，： | 1 |
| 14 | A model for the lowering of plant ethylene concentrations by plant growth-promoting bacteria显示文摘 | Bernard R G Donna M P Jiping L | 1998 | J theor Biol1998，190，： | 1 |
| 15 | CXCR4 and CXCL12 (SDF1) in prostate cancer:inhibitory effects of human single chain Fv antibodies显示文摘 | GAYLE G V SHAO B H DONNA M P | | 0，，06： | 1 |
| 16 | Toxicogenomics: a New Revolution in Drug Safety显示文摘 | ARTHUR L C MICHAEL P C DONNA L M | 2002 | Drug Discovery Today2002，7，13： | 1 |
| 17 | The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-Sodium)显示文摘 | LAURA P SVETKEY FRANK M SACKS EVA OBARZANEK WILLIAM M VOLLMER LAWRENCE J APPEL PAO-HWA LIN NJERI M KARANJA DAVID W HARSHA GEORGE A BRAY MIKEL AICKIN MICHAEL A PROSCHAN MARLENE M WINDHAUSER JANIS F SWAIN PHYLLIS B McCARRON DONNA G RHODES REESA L LAWS | 1999 | Journal of the American Dietetic Association1999，，8： | 1 |
| 18 | Thermal Stability of Cyclopentane as an Organic Rankine Cycle Working Fluid 显示文摘 | Daniel M G Lucia M P Donna PG | 2011 | Energy & fuel2011，25，： | 1 |
| 19 | Factors affecting quality of fresh-cut horticultural products 显示文摘 | Alley E W Nathanee P K Donna A M | 1996 | Postharvest Biology and Technology1996，，9： | 1 |
| 20 | Levetiracetam prophylaxis in pediat-ric migraine:an open-label study显示文摘 | Ann P Donna K Lisa M | 2007 | Headache2007，47，3： | 1 |
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