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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | A self-organizing approach to background subtraction for visual surveillance applications 显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on IP2008，17，7： | 1 |
| 4 | A vision-based particle tracking velocimetry显示文摘 | Lucia M De Nesi P | 2001 | Real-Time Imaging2001，7，2： | 1 |
| 5 | A self-organizing approach to background subtraction for visual surveillance applications 显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on Image Processing2008，17，7： | 1 |
| 6 | Reverse knowledge trans- fer in MNES: subsidiary innovativeness and entry modes显示文摘 | RAM M LUCIA P LARISSA R | 2014 | Long Range Planning2014，47，1： | 1 |
| 7 | Conflict resolution problems for air traffic management system solved with mixed integer programming显示文摘 | Lucia P Eric M F Antonio B | 2002 | IEEE Transactions on Intelligent Transportation System2002，3，1： | 1 |
| 8 | A self-organizing approach to background subtraction for visual surveillance applications显示文摘 | LUCIA M ALFREDO P | 2008 | IEEE Transactions on Image Processing2008，17，7： | 1 |
| 9 | A vision-based particle tracking velocimetry 显示文摘 | Baldassarre A De Lucia M Nesi P | 2001 | Real-Time Imaging2001，7，2： | 1 |
| 10 | Multifocal leukoencephalopathy induced by levamisole显示文摘 | Lucia P Pocek M Passacantando A | 1996 | Lancet1996，348，： | 1 |
| 11 | Oxygen isotope composition of Holocene dolomite formed in a humid hypersaline setting 显示文摘 | Major R P Lloyd R M Lucia F J | 1992 | Geology1992，20，： | 1 |
| 12 | A Self-organizing Approach to Background Subtraction for Visual Surveillance Ap- plications显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on Image Process- ing2008，17，7： | 1 |
| 13 | The heart rate variability indices and the circadian rhythm of the hourly heart rate: 2 prognostic indicators of mortality and malignant ventricular arrhythmias in patients with a myocardial infarct 显示文摘 | Curione M Lucia P Proietti E | 1996 | Cardiologia1996，41，12： | 1 |
| 14 | Thermal Stability of Cyclopentane as an Organic Rankine Cycle Working Fluid 显示文摘 | Daniel M G Lucia M P Donna P G | 2011 | Energy 8z Fuel2011，25，： | 1 |
| 15 | Heterogeneity among strains of diffusely adherent Escherichia coli isolated in brazil 显示文摘 | Lucia M L Sandra H F Antonio J P F er al | 2005 | J Clin Microbiol2005，43，4： | 1 |
| 16 | Cute ffects of 3,4-dichloroaniline on blood of male wistar rats显示文摘 | LUCIA Guihermino AMADEU M V M Soars ARSELIO P Carvalho | 1998 | Chemosphere1998，37，4： | 1 |
| 17 | Shape and phase control of colloidal ZnSe nanocrystals 显示文摘 | Davide Cozzoli P Liberato Manna Lucia Curri M | 2005 | Chemistry of materials2005，17，6： | 1 |
| 18 | Effects of diet-ary cadmium contamination on bird Anas platyrhyn-chos-comparison with species Cairina moschata显示文摘 | Lucia M Andre J M Gonzalez P?et ai | 2010 | Ecotoxicol Environ Saf2010，73，8： | 1 |
| 19 | Tetrahydrobiisoquinoline derivatives by reaction of dopamine with glyoxal: A novel po- tential degenerative pathway of catecholamines under oxida- tive stress conditions显示文摘 | Paola M Lucia P Idolo T | 2004 | Chern Res Toxicol2004，17，9： | 1 |
| 20 | Heterogeneity among strains of diffusely adherent Escherichia coli isolated in Brazil 显示文摘 | Lucia M L Sandra H F Antonio J P | 2005 | J Clin Microbiol2005，43，4： | 1 |
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