|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | A compre- hensive drought monitoring method integrating MODIS and TRMM data 显示文摘 | DU LINGTONG TIAN QINGJIU YU TAO | 2013 | International Journal of Applied Earth Observation andGeoinformation2013，23，： | 1 |
| 3 | A comprehensive drought monitoring method integrating MODIS and TRMM data显示文摘 | Du Lingtong Tian Qingjiu Yu Tao | 2013 | International Journal of Applied Earth Observation and Geoinformation2013，23，1： | 1 |
| 4 | A compre- hensive drought monitoring method integrating MODIS and TRMM data显示文摘 | Du Lingtong Tian Qingjiu Yu Tao | 2013 | International Journal of Applied Earth Observation & Geoinformation2013，23，8： | 1 |
| 5 | A comprehensive drought monitoring method integrating MODIS and TRMM data显示文摘 | Du Lingtong Tian Qingjiu Yu Tao | 2013 | International Journal of Applied Earth Observation and Geoinformation2013，23，1： | 1 |
| 6 | A field investigation of wind erosion in the farming–pastoral ecotone of northern China using a portable wind tunnel: a case study in Yanchi County显示文摘The farming–pastoral ecotone in northern China is an extremely fragile ecological zone where wind erosion of cropland and rangeland is easy to occur. In this study, using a portable wind tunnel as a wind simulator, we conducted field simulated wind erosion experiments combined with laboratory analysis to investigate wind erosion of soils in trampled rangeland, non-tilled cropland and tilled cropland in Yanchi County, China. The results showed that compared with rangeland, the cropland had a higher soil water holding capacity and lower soil bulk density. The wind erosion rate of trampled rangeland was much higher than those of non-tilled cropland and tilled cropland. For cropland, the wind erosion rate of the soil after tilling was surprisingly less than that of the soil before tilling. With increasing of wind speed, the volume mean diameter of the eroded sediment collected by the trough in the wind tunnel generally increased while the clay and silt content decreased for all soils. The temporal variation in wind erosion of the trampled rangeland indicated that particle entrainment and dust emission decreased exponentially with erosion time through the successive wind erosion events due to the exhaustion of erodible particles. | nan ling dong zhibao xiao weiqiang li chao xiao nan song shaopeng xiao fengjun du lingtong | 2018 | Journal of Arid Land2018，10，1： | 0 |
| 7 | Characterization of putative mannoprotein in Kluyveromyces lactis for lactase production显示文摘Lactase is a member of theβ-galactosidase family of enzymes that can hydrolyze lactose into galactose and glucose.However,extracellular lactase production was still restricted to the process of cell lysis.In this study,lactase-producing Kluyveromyces lactis JNXR-2101 was obtained using a rapid and sensitive method based on the fluorescent substrate 4-methylumbelliferyl-β-D-galactopyranoside.The purified enzyme was identified as a neutral lactase with an optimum pH of 9.To facilitate extracellular production of lactase,a putative mannoprotein KLLA0_E01057g of K.lactis was knocked out.It could effectively promote cell wall degradation and lactase production after lyticase treatment,which showed potential on other extracellular enzyme preparation.After optimizing the fermentation conditions,the lactase yield from mannoprotein-deficient K.lactis JNXR-2101ΔE01057g reached 159.62 U/mL in a 5-L fed-batch bioreactor. | Xiuru Shen Lingtong Liao Guoqiang Zhang Jingwen Zhou Jianghua Li Guocheng Du | 2023 | Synthetic and Systems Biotechnology2023，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员