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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Carbon dioxide fluxes over bermudagrass, native prairie and sorghum显示文摘 | Dugas W A Heuer M L Mayeux H S | 1999 | A gricultural and Forest Meteorology1999，93，： | 1 |
| 3 | Carbon dioxide capture with concentrated, aqueous piperazine显示文摘 | Freeman S A Dugas R Wagener D H V | 2010 | International JournalofGreenhouse Gas Control2010，4，2： | 1 |
| 4 | Car- bon Dioxide Capture with Concentrated,Aqueous Piperazine 显示文摘 | FREEMAN S A DUGAS R VAN WAGENER D | 2009 | Energy Procedia2009，1，1： | 1 |
| 5 | Quasi-duo rings and stable range decent显示文摘 | LAM T Y DUGAS A S | 2005 | J Pure &Appl Alg2005，195，： | 1 |
| 6 | Carbon dioxide fluxes over Bermuda grass,native prairie and sorghum显示文摘 | Dugas W A Heuer M L Mayeux H S | 1999 | Agricultural and Forest Meteorology1999，93，2： | 1 |
| 7 | Environmentally persistent free radicals are redox active and more eytotoxie than the average Ultrafine Particie显示文摘 | Dugas T R Heber V Y Dellinger B Lomnicki S Cormier S A Varner K J | 2009 | Free Radical Biology and Medicine2009，，： | 1 |
| 8 | Google flu trends: correlation with emergency department influenza rates and crowding metrics显示文摘 | DUGAS A F HSIEH Y LEVIN S | 2012 | Clinieal Infectious Diseases2012，54，4： | 1 |
| 9 | Carbon dioxidecapture with concentrated, aqueous piperazine 显示文摘 | Freeman S A Dugas R Wagener D V | 2009 | EnergyProcedia2009，1，： | 1 |
| 10 | Carbon dioxide fluxes over Bermudagrass, native prairie and sorghum 显示文摘 | Dugas W A Heuer M L Myeux H S | 1999 | Agricultural and Forest Meteorology1999，93，21： | 1 |
| 11 | Analysis of the 16S rRNA gene sequence of the coryneform bacterium associated with hyperker- atotic dermatitis of athymic nude mice and development of a PCB - based detection assay显示文摘 | DUGA S GOBBI A ASSELTA B | 1998 | Mol Cell Probes1998，12，4： | 1 |
| 12 | Carbon dioxide capture with concentrated, aqueous piperazine 显示文摘 | Freeman S A Dugas R Van Wagener D | 2009 | Energy Proledia2009，1，1： | 1 |
| 13 | Carbon Dioxide Capture with Concentrated,Aqueous Piperazine显示文摘 | Freeman S A Dugas R Wagener D H V | 2010 | International Journal of Greenhouse Gas Control2010，4，2： | 1 |
| 14 | Analysis of the 16S rRNA gene sequence of the coryneform bacterium associated with hyperkeratotic dermatitis of athymic nude mice and development of a PCR N based detection assay显示文摘 | Duga S Gobbi A Asselta R | 1998 | Mol Cell Probes1998，12，： | 1 |
| 15 | Carbon dioxide capture with concentrated, aqueous piperazine 显示文摘 | Freeman S A Dugas R Wagener D V | 2009 | Energy Procedia2009，1，1： | 1 |
| 16 | Failure of uterine fibroid em- bolization 显示文摘 | Huang JYJ Kafy S Dugas A | 2006 | Fertil Steril2006，85，1： | 1 |
| 17 | An intranet database for a university hospital drug information center显示文摘 | Dugas M Weinzierl S Pecar A | 2001 | Am J Health Syst Pharm2001，58，9： | 1 |
| 18 | Analysis of the 16S rRNA gene sequence of the coryneform bacterium associated with hyperkeratotic dermatitis of athymic nude mice and development of a PCR-based detection assay 显示文摘 | Duga S Gobbi A | 1998 | Mol Cell Probes1998，12，4： | 1 |
| 19 | Heat balance, porometer, and deuterium estimates of transpiration from potted trees 显示文摘 | Dugas W A Wallace J S Allen S J | 1993 | Agricultural and Forest Meteorology1993，64，： | 1 |
| 20 | Carbon dioxide fluxes over bermudagrass, native prairie, and sorghum显示文摘 | Dugas W A Heuer M L Mayeux H S | 1999 | Agricul- ture and Forest Meteorology1999，93，： | 1 |
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