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| 1 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 2 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 3 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 4 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 5 | 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis显示文摘 | Jacqueline E Tate Anthony H Burton Cynthia Boschi-Pinto A Duncan Steele Jazmin Duque Umesh D Parashar | 2012 | The Lancet Infectious Diseases2012，，2： | 2 |
| 6 | The sillca content of plant polysaccharides显示文摘 | Khalil N F Duncan H J | 1981 | Journal of the Science of Food and Agriculture1981，，32： | 2 |
| 7 | Comparison of methods to detect biosurfactant production by diverse microorganisms 显示文摘 | Youssef N H Duncan K E Nagle D P | 2004 | Journal of Microbiological Methods2004，56，3： | 1 |
| 8 | Isolation and characterization of secretions from the plant-parasitic nematode Globodera pallida 显示文摘 | ROBERTSON L ROBERTSON W M | 1997 | Source Parasitology1997，115，4： | 1 |
| 9 | Influence of diesel fuel on seed germina-tion显示文摘 | ADAM G DUNCAN H | 2002 | Environmental Pollution2002，120，2： | 1 |
| 10 | The microbiology of butyrate formation in the human colon显示文摘 | PRYDE S E DUNCAN S H HOLD G L | 2002 | FEMS Microbiology Letters2002，217，2： | 1 |
| 11 | Deformable boundary finding in medical images by integrating gradient and region information显示文摘 | Chakraborty A Staib H Duncan J | 1996 | IEEE Transactions on Medical Imaging1996，15，6： | 1 |
| 12 | Lactate utilizing bacteria,isolated from human faeces,that produce butyrate as a major fermentation product显示文摘 | Duncan S H Louis P Flint H J | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 13 | Boundary fitting with parametrically deformable models显示文摘 | Staib L H Duncan J S | 1992 | IEEE Transactions on Pattern Analysis and Machine Intelligence1992，14，11： | 1 |
| 14 | The microbiology of butyrate formation in the human colon显示文摘 | Pryde S E Duncan S H Hold G L | 2002 | FEMS Microbiology Letters2002，217，： | 1 |
| 15 | Access to green space, physical activity and mental health: a twin study 显示文摘 | COHEN-CLINE H TURKHEIMER E DUNCAN G E | 2015 | Journal of epidemiology and community health2015，69，6： | 1 |
| 16 | Effects of polycy-clic aromatic hydrocarbons on germination and subsequent growth of grasses and legumes in freshly contaminated soil and soil with aged PAHs residues显示文摘 | SMITH M J FLOWERS T H DUNCAN H J | 2006 | Environmental Pollution2006，141，3： | 1 |
| 17 | Web space reconstruction with a M-V flap显示文摘 | LEWIS R C NORDYKE M D DUNCAN K H | 1988 | J Hand Surg Am1988，13，1： | 1 |
| 18 | Targeting the TLR4/MD - 2 complex for imaging inflammation by SPECT/CT显示文摘 | Smith A Duncan H Duan D | 2011 | J Nucl Med2011，52，1： | 1 |
| 19 | Pro- duction and response of human prostate cancer cell lines to granulocyte macrophage-eolony stimulating factor显示文摘 | Lang S H Miller W R Duncan W Habib F K | 1994 | Int J Cancer1994，59，： | 1 |
| 20 | Mechanotransduction and the functional response of bone to mechanical strain显示文摘 | Duncan R L Turner C H | 1995 | Calcif Tissue Int1995，57，5： | 1 |
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