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5篇 您的检索式:作者名="Dacheng Hong"
    题名 作者 年代 出处 被引量
1TSdb:A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates显示文摘TSdb (http://gffzzf860537ad99741d5hvbo6wv56vbbc6fwx.ffgz.tsg.suse.edu.cn) is the first manually curated central repository that stores formatted information on the substrates of transporters. In total, 37608 transporters with 15075 substrates from 884 organisms were curated from UniProt functional annotation. A unique feature of TSdb is that all the substrates are mapped to identifiers from the KEGG Ligand com- pound database. Thus, TSdb links current metabolic pathway schema with compound transporter systems via the shared compounds in the pathways. Furthermore, all the transporter substrates in TSdb are classified according to their biochemical properties, biological roles and subcellular localizations. In addition to the functional annotation of transporters, extensive compound annotation that includes inhibitor information from the KEGG Ligand and BRENDA databases has been integrated, making TSdb a useful source for the discovery of potential inhibitory mechanisms linking transporter substrates and metabolic enzymes. User-friendly web interfaces are designed for easy access, query and download of the data. Text and BLAST searches against all transporters in the database are provided. We will regularly update the substrate data with evidence from new publications.ZHAO Min CHEN YanMing QU DaCheng QU Hong 2011Science China(Life Sciences)2011,54,1:6
2miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer显示文摘Dacheng Wen Songhe Li Fujian Ji Hong Cao Weidong Jiang Jiaming Zhu Xuedong Fang 2013Tumor Biology2013,,:2
3Selective excitation of resonances in gammadion metamaterials for terahertz wave manipulation显示文摘A gammadion terahertz(THz) metamaterial embedded with a pair of splits is experimentally investigated. By introducing the pair of splits at different arms, the transmitted amplitude at the resonance frequency can be manipulated from 61% to 24%. Broadband static resonance tunability from 1.11 to 1.51 THz is also demonstrated via varying the relative split positions at certain arms. The amplitude change and static resonance tunability are attributed to the introduced split pairs, which enable selective excitation of different resonance modes in the gammadion metamaterials. This work promises a new approach to design THz functional devices.WANG DaCheng HUANG Qin QIU ChengWei HONG MingHui 2015Science China(Physics,Mechanics & Astronomy)2015,58,8:2
4Complementary bilayer metasurfaces for enhanced terahertz wave amplitude andphase manipulation显示文摘Manipulation of terahertz wave by metasurfaces has shown tremendous potential in developing compact and functional terahertz optical devices.Here,we propose complementary bilayer metasurfaces for enhanced terahertz wave amplitude and phase manipulation.The metasurfaces are composed of one layer of metal cut-wire arrays and one layer of their complementary aperture arrays separated by a dielectric spacer.Through the near-field coupling between transverse magnetic resonances in the metal apertures and electric resonances in the metal cut-wires,the structures can manipulate the cross polarization conversion and phase dispersion of terahertz wave.Particularly,the designed metasurfaces demonstrate a phase delay of 180°between two orthogonal axes with the same transmission amplitude between 0.70 and 1.0 THz,enabling a 45°broadband polarization conversion.When the metal cut-wires are rotated with respect to the apertures or the thickness of the dielectric spacer is changed,the amplitude and phase dispersion of the transmitted terahertz wave can be tuned.Such complementary coupled bilayer metasurfaces offer a new method to control the amplitude and phase dispersion of terahertz wave and promise great potential for applications in terahertz meta-devices.Dacheng Wang Yandong Gong Minghui Hong 2017光电工程2017,44,1:0
5Synthetic studies towards atkamine显示文摘Atkamine is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters,and therefore it is a highly challenging target for synthetic chemists.We herein reported a modular synthetic strategy toward this alkaloid,featuring a formal [5+2] annulation and an asymmetric Michael addition.The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved.A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5+2] annulation.Feng Zhang Yujie Niu Dacheng Hong Yilin Ye Yuhui Hua Shihao Ding Yandong Zhang 2021Chinese Chemical Letters2021,32,2:0
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