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| 1 | Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients显示文摘AIM: To investigate the correlation among tumor markers, curative resection, and recurrence in gastric cancer.METHODS: The patients with preoperative tumormakers [Carcinoembryonic antigen, Carbohydrate antigen(CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, retrospectively.RESULTS: Among the 679 patients with gastric cancer, curative resection was 93.6%(n = 636) and noncurative resection was 6.4%(n = 43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level(HR = 2.431, P =0.020), in a multivariate analysis. CONCLUSION: Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients. | Dae Hoon Kim Hyo Yung Yun Dong Hee Ryu Hye-Suk Han Joung-Ho Han Soon Man Yoon Sei Jin Youn | 2015 | World Journal of Gastroenterology2015，21，4： | 6 |
| 2 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 3 | Transcriptional profiling of ESTs responsive to Rhizobium vitis from ‘Tamnara’ grapevines ( Vitis sp.)显示文摘 | Youn Jung Choi Hae Keun Yun Kyo Sun Park Jeong Ho Noh Youn Young Heo Seung Hui Kim Dae Won Kim Hee Jae Lee | 2010 | Journal of Plant Physiology2010，，13： | 1 |
| 4 | A Co-Operative Study: Clinical Characteristics of 334 Korean Patients with Moyamoya Disease Treated at Neurosurgical Institutes (1976–1994)显示文摘 | Dae Hee Han O-Ki Kwon Bark Jang Byun Byung Yeon Choi Chang Wha Choi Joong Uhn Choi Seon Gil Choi Jong Oung Doh Jong Woo Han Shin Jung Sung Don Kang Dae Jo Kim Hyoung-Ihl Kim Hyung Dong Kim Moon Chul Kim Sang Chul Kim Soo Chun Kim Youn Kim Byung Duk Kwun B | 2000 | Acta Neurochirurgica2000，，11： | 1 |
| 5 | Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women显示文摘AIM: To evaluate the association between the severity of liver steatosis and metabolic syndrome in apparently healthy Korean adults.METHODS: We examined 1 022 men and women, aged 30-79 years, who participated in a health screening test.A standard interview, anthropometrics, biochemical studies,and abdominal ultrasonography were conducted for each participant. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel Ⅲ, with a modification for the waist circumference cut-off level. The severity of liver steatosis was evaluated using liver ultrasonography, and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GT) levels were determined.RESULTS: Ultrasonographic liver steatosis was strongly associated with metabolic syndrome and common metabolic abnormalities. Compared with people without steatosis, people with mild, moderate, and severe steatosis had adjusted odds ratios for metabolic syndrome of 1.72(95%CI, 1.01-2.94), 2.89 (1.75-4.76) and 3.53 (1.25-9.98)in men, and 2.86 (1.64-5.01), 3.19 (1.80-5.65) and 3.70(0.82-16.73) in women, respectively. The serum AST level was not associated with metabolic syndrome. The serum ALT and γ-GT levels were significantly associated with metabolic syndrome in men but not in women.CONCLUSION: The occurrence of metabolic syndrome shows a stronger association with the severity of ultrasonographic steatosis than with the serum liver enzyme levels. The degree of fatty infiltration detected on ultrasonography can be used as an indicator of liver dysfunction attributable to metabolic abnormalities. | Hyeon Chang Kim Sung Hee Choi Hae Won Shin Jae Youn Cheong Kwan Woo Lee Hyun Chul Lee Kap Bum Huh Dae Jung Kim | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 6 | A Lattice/Transversal Joint(LTJ) Structure for an Acoustic Echo Canceller 显示文摘 | Jae Ha Yoo Sung Ho Cho Dae Hee Youn | 1995 | Circuits and Systems1995，2，： | 1 |
| 7 | Detection of Plasmodiophora brassicae by Using Polymerase Chain Re-action显示文摘 | HEE YOUN CHEE WAN GYU KIM WEON DAE CHO | 1998 | Korean Journal of Plant Pathol1998，14，6： | 1 |
| 8 | Fast active noise control algorithm for car exhaust noise control显示文摘 | Hyuck-Jae Lee Young-Cheol Park Chungyong Lee Dae Hee Youn | 2000 | Electronics Letters2000，，36： | 1 |
| 9 | Temporal domain processing for a synthetic aperture array显示文摘 | Seungil Kim Dae Hee Youn CHungyong Lee | 2002 | IEEE Journal of oceanic engineering2002，27，2： | 1 |
| 10 | On compensating nonlinear distortions of an OFDM system using an efficient adaptive predistorter显示文摘 | Hyun Woo Kang Yong Soo Cho Dae Hee Youn | 1999 | IEEE Trans on Communications1999，47，4： | 1 |
| 11 | Detection of Plasmodiophora brassicae by using polymerase chain reaction显示文摘 | Chee Hee Youn Wan Gyu Kim Woen Dae Cho | 1998 | Korea J Plant Pathol1998，14，： | 1 |
| 12 | Software Optimization of the MPEG - Audio Decoder Using a 32 -bit MCU RISC Processor显示文摘 | Keun - Sup Lee Young Cheol Park' Dae Hee Youn | 2002 | IEEE Transations on Consumer Electronics2002，48，3： | 1 |
| 13 | Temporal domain processing for a synthetic aperture array显示文摘 | Seungil Kim Dae Hee Youn and CHungyong Lee | 2002 | IEEE Journal of oceanic engineering2002，27，2： | 1 |
| 14 | Effects of aqueous extract from red Liriope platyphylla on phthalic-anhydride-induced atopic dermatitis in Interleukin-4/Luciferase/Consensus non-coding sequence-1 transgenic mice evaluated in terms of luciferase signal and general phenotype biomarkers显示文摘OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 weeks.METHODS: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot analysis.RESULTS: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated group.CONCLUSION: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia. | Moon Hwa Kwak Ji Eun Kim Jun Go Hong Joo Son Hee Seob Lee Jin Tae Hong Dae Youn Hwang | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 0 |
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