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| 1 | Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis显示文摘AIM: To evaluate whether Helicobacter pylori(H. pylori) eradication therapy benefits patients with functional dyspepsia(FD).METHODS: Randomized controlled trials(RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English(up to May 2015) were identified by searching Pub Med, EMBASE, and The Cochrane Library. Pooled estimates were measured using the fixed or random effect model. Overall effect was expressed as a pooled risk ratio(RR) or a standard mean difference(SMD). All data were analyzed with Review Manager 5.3 and Stata 12.0.RESULTS: This systematic review included 25 RCTs with a total of 5555 patients with FD. Twenty-three of these studies were used to evaluate the benefits of H. pylori eradication therapy for symptom improvement; the pooled RR was 1.23(95%CI: 1.12-1.36, P < 0.0001). H. pylori eradication therapy demonstrated symptom improvement during long-term follow-up at ≥ 1 year(RR = 1.24; 95%CI: 1.12-1.37, P < 0.0001) but not during short-term follow-up at < 1 year(RR = 1.26; 95%CI: 0.83-1.92, P = 0.27). Seven studies showed no benefit of H. pylori eradication therapy on quality of life with an SMD of-0.01(95%CI:-0.11 to 0.08, P = 0.80). Six studies demonstrated that H. pylori eradication therapy reduced the development of peptic ulcer disease compared to no eradication therapy(RR = 0.35; 95%CI: 0.18-0.68, P = 0.002). Eight studies showed that H. pylori eradication therapy increased the likelihood of treatment-related side effects compared to no eradication therapy(RR = 2.02; 95%CI: 1.12-3.65, P = 0.02). Ten studies demonstrated that patients who received H. pylori eradication therapy were more likely to obtain histologic resolution of chronic gastritis compared to those who did not receive eradication therapy(RR = 7.13; 95%CI: 3.68-13.81, P < 0.00001).CONCLUSION: The decision to eradicate H. pylori in patients with functional dyspepsia requires individual assessment. | Li-Jun Du Bin-Rui Chen John J Kim Sarah Kim Jin-Hua Shen Ning Dai | 2016 | World Journal of Gastroenterology2016，22，12： | 30 |
| 2 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 3 | Bone morphogenetic protein 2 promotes transforming growth factor β3-induced chondrogenesis of human osteoarthritic synovium-derived stem cells显示文摘有更高的 chondrogenic 潜力的背景导出 Synovium 的干细胞(SDSC ) 为软骨新生作为房间来源正在吸引可观的注意。我们调查了骨头的效果形态基因的蛋白质(BMP-2 ) 2 在转变生长因素 beta3 (TGF-3 ) 以后导致了在一个小团文化系统从人的 osteoarthritic synovium 孤立的 SDSC 的 chondrogenesis。clonogenicity,干细胞标记表示和孤立的 SDSC 的多区别潜力被殖民地形成统一试金,流动 cytometry 并且包括分别地染色的茜素红 S,油红 O 和 alcian 蓝色的特定的染色决定的方法。SDSC 小团在与或没有 TGF-3 或 / 并且 BMP-2 中等的 chondrogenic 是有教养的。在白天 21 点,直径和小团的重量被测量。SDSC 的 Chondrogenic 区别被藏红染料 O 染色,骨胶原类型染色的 immunohistochemical, sulfated glycosaminoglycan (sGAG ) 合成和骨胶原类型, aggrecan, SOX9,连接蛋白质,骨胶原类型 X 和 BMP 受体的 mRNA 表示评估。在优化 culturing 密度(104/60 cm2 ) 下面孤立的结果房间显示出 clonogenicity 和多区别潜力。这些房间是积极的(99 ) 为 CD44, CD90, CD105 并且否定(10 ) 为 CD34 和 CD71。在包含 TGF-3 与或没有 BMP-2 的 chondrogenic 媒介区分到 chondrocytic 显型的 SDSC。细胞外的矩阵染色的藏红染料 O 是积极的,骨胶原类型的表示被检测。房间小团独自与 TGF-3 对待, BMP-2 在直径和重量是更大的,生产了更多的 sGAGs,并且表示了骨胶原类型和另外的 chondrogenic 标记的高水平,比有 TGF-3 的媒介,除了 COL10A1。结论 SDSC 能从人的 osteoarthritic synovium 被孤立。有 BMP-2 的补充显著地支持了在里面 SDSC 的 vitro TGF-3-induced chondrogenic 区别。 | RUI Yun-feng DU Lin WANG You WANG Yang LUI Pauline po-yee TANG Ting-ting CHAN Kai-ming DAI Ke-rong | 2010 | Chinese Medical Journal2010，，21： | 19 |
| 4 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 5 | ^(18)F-FDG uptake as a biologic factor predicting outcome in patients with resected non-small-cell lung cancer显示文摘背景 non-small-cell 肺癌症(NSCLC ) 的外科的治疗的结果仍然保持差。在许多病人, NSCLC 的生物行为不跟随一个明确的模式,并且不能精确地在治疗前被预言。正电子排放断层摄影术(宠物) 上的 18F-fluoro-2-deoxy-glucose (18F-FDG ) 举起与 NSCLC 的攻击性被联系。现在的学习在与回顾的分析用经历了完全的切除术和外科手术前的 FDG 宠物的 82 个病人做的 NSCLC.Methods A 预言通过手术对待的病人的结果集中了于 18F-FDG 举起的角色。最大值标准化了举起价值(SUVmax ) ,除了五个 clinicopathological 因素和三 biomolecular 因素,能可能影响幸存,与病人的复发和幸存为可能的协会被作比较,由比例的危险在 multivariate 分析建模的 univariate 分析和艇长的木头等级测试。在 SUVmax 和另外的因素之间的协会也被分析。有 SUVmax 的结果病人超过 11 与不到 11 在 univariate 分析的 SUVmax 有没有疾病的幸存和比病人短的全面幸存(P0.001, P=0.002 ) 。在 multivariate 分析, SUVmax (在 11 的 dichotomized ) 是为肿瘤复发的唯一的重要预言者。TNM 舞台和 SUVmax (在 11 的 dichotomized ) 是为全面幸存的独立预言者。有 p53 overexpression 的 SUVmax 的协会,增殖的房间把肿瘤的索引和 microvascular 密度标记的原子抗原(PCNA ) 在全部组是重要的。宠物上的结论 18F-FDG 举起可以被用来 noninvasively 在 vivo 估计 NSCLC 的生物攻击性,识别能得益于另外的治疗的有差的预后的通过手术对待的病人。 | ZHANG Zhen-jiang CHEN Jing-han MENG Long DU Jia-jun ZHANG Lin LIU Ying DAI Hong-hai | 2007 | Chinese Medical Journal2007，，2： | 17 |
| 6 | Flower-, wire-, and sheet-like MnO_2-deposited diatomites:Highly efficient absorbents for the removal of Cr(Ⅵ)显示文摘Flower-, wire-, and sheet-like MnO2-deposited diatomites have been prepared using a hydrothermal method with Mn(Ac)2, KMnO4and/or MnSO4 as Mn source and diatomite as support. Physical properties of the materials were characterized by means of numerous analytical techniques, and their behaviors in the adsorption of chromium(VI) were evaluated.It is shown that the MnO2-deposited diatomite samples with different morphologies possessed high surface areas and abundant surface hydroxyl groups(especially the wire-like MnO2/diatomite sample). The wire-like MnO2/diatomite sample showed the best performance in the removal of Cr(VI), giving the maximum Cr(VI) adsorption capacity of 101 mg/g. | Yucheng Du Liping Wang Jinshu Wang Guangwei Zheng Junshu Wu Hongxing Dai | 2015 | Journal of Environmental Sciences2015，27，3： | 17 |
| 7 | Role of RECK methylation in gastric cancer and its clinical significance显示文摘AIM:To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.METHODS:Methylation of RECK gene in 40 paired samples of gastric cancer and its corresponding adjacent normal mucosa,lymph nodes and peritoneal irrigation fluid was detected by methylation-specific polymerase chain reaction.RESULTS:Aberrant methylation of RECK gene was detected in 27.5%(11/40)of the adjacent normal mucosa samples,in 47.5%(19/40)of gastric cancer samples,in 57.1%(12/21)of the lymph node samples,and in 35%(14/40)of peritoneal irrigation fluid samples,respectively,with a significant difference between the adjacent normal mucosa and lymph node samples(P=0.023).Presence of RECK methylation in the primary tumor samples was significantly correlated with tumor invasion(P=0.023).The accuracy of RECK methylation in peritoneal lavage fluid samples for the diagnosis of peritoneal metastasis of gastric cancer was 72.5%(26/40),with a sensitivity of 66.7%(6/9) and a specificity of 74.2%(23/31).CONCLUSION:Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer. | Du, Yun-Yi Dai, Dong-Qiu Yang, Zhi | 2010 | World Journal of Gastroenterology2010，16，7： | 16 |
| 8 | Myocardial infarction secondary prevention study (MISPS)显示文摘Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries. | Hongcai SHANG Guohua DAI Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang WENG Tiancai WEN Boli ZHANG | 2006 | Journal of Geriatric Cardiology2006，3，2： | 14 |
| 9 | Water-bathing synthesis of high-surface-area zeolite P from diatomite显示文摘Zeolite P was synthesized for the first time via a novel water-bathing route at 90 C using scrubbed diatomite,sodium hydroxide,and aluminum hydroxide as precursor,with SiO 2/Al 2 O 3,SiO 2/Na 2 O,and H 2 O/Na 2 O molar ratios of 7.43,3.81,and 80.00,respectively.The as-fabricated samples were characterized by means of scanning electron microscopy,X-ray diffraction,and nitrogen adsorption measurements.This study showed that (i) treating the diatomite raw material with sodium hexametaphosphate could open the pores in the diatomite via removal of the clay clogged in its pores;(ii) tetragonal mesoporous zeolite P samples with a surface area of 56-60 m 2/g could be generated after 6-24 h of water-bathing reaction at 90 C;(iii) extension of water-bathing reaction time could improve the mesoporous structure of zeolite P;and (iv) Ca 2+ adsorption capacity of the zeolite P sample was about 300 cmol/kg.Such high-surface-area porous zeolite P could be used as an effective adsorbent for the treatment of water containing calcium and magnesium ions. | Yucheng Du Shuli Shi Hongxing Dai | 2011 | Particuology2011，9，2： | 14 |
| 10 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 11 | Growth induction of hepatic stimulator substance in hepatocytes through its regulation on EGF receptors显示文摘The cytosolic liver-specific growth factor-hepatic stimulator substance (HSS) has been shown to be able to amplify the rat hepatocyte proliferation responded to EGF. In order to get more insight into the mechanism, the regulatory effect of HSS on EGF-receptor(EGF-R) and the receptor phosphorylation at molecular level was studied. HSS partially purified from weanling rat liver was given to cultured hepatocytes and its influence on EGF-R specific binding and internalization as well as mRNA expression were investigated. The results showed that preincubation of hepatocytes with HSS could lead to an increase in [125I]-EGF binding to its receptors and inhibit EGFinduced receptor down-regulation. Furthermore, the overexpression of EGF-R mRNA stimulated by HSS was seen during 2-12 h after the incubation. Additionally, it was demonstrated with human hepatoma sMMC-7721 cells in Western blot that the EGF-R expression and the receptor autophosphorylation were increased with dose/timedependency after HSS treatment. These results strongly suggest that the mechanism of HSS action on hepatocyte growth might be related to its modulation on EGF-R and receptor-mediated signaling transduction. | AN WEI XIAO JUN LIU TIAN GUANG LEI JIE DAI GUO GUANG DU(Department of Cell Biology, Capital University of Medical Sciences, Beijing 100054, China) | 1999 | Cell Research1999，9，1： | 13 |
| 12 | Three-dimensional Cure Simulation of Stiffened Thermosetting Composite Panels显示文摘Stiffened thermosetting composite panels were fabricated with co-curing processing.In the co-curing processing,the temperature distribution in the composite panels was nonuniform.An investigation into the threedimensional cure simulation of T-shape stiffened thermosetting composite panels was presented.Flexible tools and locating tools were considered in the cure simulation.Temperature distribution in the composites was predicted as a function of the autoclave temperature history.A nonlinear transient heat transfer finite element model was developed to simulate the curing process of stiffened thermosetting composite panels.And a simulation example was presented to demonstrate the use of the present finite element procedure for analyzing composite curing process.The glass/polyester structure was investigated to provide insight into the nonuniform cure process and the effect of flexible tools and locating tools on temperature distribution.Temperature gradient in the intersection between the skin and the flange was shown to be strongly dependent on the structure of the flexible tools and the thickness of the skin. | Guangquan Yue,Boming Zhang ,Fuhong Dai and Shanyi Du Center for Composite Materials,Harbin Institute of Technology,Harbin 150080,China | 2010 | Journal of Materials Science & Technology2010，26，5： | 13 |
| 13 | Effect of molybdenum content on the microstructure and corrosion behavior of FeCoCrNiMox high-entropy alloys显示文摘The effect of Mo content on the microstructure revolution and corrosion behavior of cast FeCoCrNiMox high-entropy alloys in chloride environments were investigated.Results indicate that FeCoCrNi and FeCoCrNiMo0.1 alloys are in single FCC solid solution.The precipitates form in FeCoCrNiMo0.3 and increase in FeCoCrNiMo0.6 alloys.Pitting occurs on FeCoCrNi and FeCoCrNiMo0.1 alloys while FeCoCrNiMo0.3 and FeCoCrNiMo0.6 alloys suffer from preferential localized corrosion at the regions depleted in Cr and Mo.The higher Cr2O3/Cr(OH)3 ratio and the incorporation of Mo oxides make the passive film more protective and the corrosion resistance of the FeCoCrNiMo0.1 alloy is thus enhanced.The correlation between microstructure and corrosion behavior and the corresponding corrosion mechanism were clarified. | Chunduo Dai Tianliang Zhao Cuiwei Du Zhiyong Liu Dawei Zhang | 2020 | Journal of Materials Science & Technology2020，42，11： | 13 |
| 14 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 15 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 16 | Application of joint elastic impedance inversion in the GD Oilfield显示文摘为对 GD 油矿的复杂水库描述, P 波浪和 S 波浪有弹性的阻抗倒置被执行用预先叠精确地识别水库的岩性学的地震数据。联合倒置用三被执行或克服不能满足复杂水库描述的要求的栈以后的地震倒置的奇特并且避免倒置结果的不稳定性的更偏爱的栈在预先叠集合由低信号噪音比率引起了。prestack 橡皮阻抗倒置的基本理论简短在这篇论文被描述,用 GD 油矿的真实数据,钥匙角度集合小浪抽取,地平线刻度, S 波浪速度预言,和有弹性的参数抽取走被分析并且学习。从日志分析决定的多重有弹性的参数的全面解释是改进 prestack 的效果的关键地震倒置。 | Dai Xiaofeng Gan Lideng Du Wenhui Wang Ping | 2006 | Applied Geophysics2006，3，1： | 11 |
| 17 | Isolation and Identification of Virus dsRNA from Strawberry Plants显示文摘The analysis of virus genome is based on nucleic acid isolation. The aims of this study were to develop a method forisolation and identification of virus double-stranded ribonucleic acid (dsRNA) and to elucidate the nucleotide sequencesof strawberry virus. Using the modified method, virus dsRNA was extracted from strawberry virus indicator plants andcultivated strawberry plants and detected using agarose gel electrophoresis with ethidium bromide staining and reversetranscription-polymerase chain reaction (RT-PCR). The quantity of virus dsRNA varied among strawberry cultivars. Thequantity of dsRNA from in vitro plantlets was higher than that from the young leaves of field plants. For the field-grownplants, there was more dsRNA in the young leaves. Virus dsRNA extracted from strawberry plants was resistant todeoxyribonuclease Ⅰ(DNase Ⅰ), but evidently, it became resistant to ribonuclease A (RNase A) only in the presence of0.5 M NaCl. Its bands in agarose gel could be readily recycled using an agarose gel DNA purification kit. With RT-PCR,the segments of both strawberry mottle virus and Strawberry mild yellow edge virus genomes were amplified by usingthe virus dsRNA recycled from gel or treated with DNase Ⅰ /RNase A as templates. The system developed for dsRNAisolation and identification in strawberry plants laid a sound foundation for the work on genome analysis of strawberryvirus isolates in China. | LI He DAI Hong-yan ZHANG Zhi-hong GAO Xiu-yan DU Guo-dong ZHANG Xin-yu | 2007 | Agricultural Sciences in China2007，6，1： | 10 |
| 18 | A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells显示文摘Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer. | Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 10 |
| 19 | Science and Prediction of Heavy Rainfall over China:Research Progress since the Reform and Opening-Up of New China显示文摘This paper reviews the major progress on development of the science and prediction of heavy rainfall over China since the beginning of the reform and opening-up of new China(roughly between 1980 and 2019).The progress of research on the physical mechanisms of heavy rainfall over China is summarized from three perspectives:1)the relevant synoptic weather systems,2)heavy rainfall in major sub-regions of China,and 3)heavy rainfall induced by typhoons.The development and application of forecasting techniques for heavy rainfall are summarized in terms of numerical weather prediction techniques and objective forecasting methods.Greatly aided by the rapid progress in meteorological observing technology and substantial improvement in electronic computing,studies of heavy rainfall in China have advanced to investigating the evolution of heavy-rain-producing storms and observational analysis of the cloud microphysical features.A deeper and more systematic understanding of the synoptic systems of importance to the production of heavy rainfall has also been developed.Operational forecast of heavy rainfall in China has changed from subjective weather event forecasts to a combination of both subjective and objective quantitative precipitation forecasts,and is now advancing toward probabilistic quantitative precipitation forecasts with the provision of forecast uncertainty information. | Yali LUO Jisong SUN Ying LI Rudi XIA Yu DU Shuai YANG Yuanchun ZHANG Jing CHEN Kan DAI Xueshun SHEN Haoming CHEN Feifan ZHOU Yimin LIU Shenming FU Mengwen WU Tiangui XIAO Yangruixue CHEN Huiqi LI Mingxin LI | 2020 | Journal of Meteorological Research2020，34，3： | 10 |
| 20 | Kinetic studies of gas hydrate formation with low-dosage hydrate inhibitors显示文摘Pipeline blockage by gas hydrates is a serious problem in the petroleum industry.Low-dosage inhibitors have been developed for its cost-effective and environmentally acceptable characteristics.In a 1.072-L reactor with methane,ethane and propane gas mixture under the pressure of about 8.5 MPa at 4 °C,hydrate formation was investigated with low-dosage hydrate inhibitors PVP and GHI1,the change of the compressibility factor and gas composition in the gas phase was analyzed,the gas contents in hydrates were compared with PVP and GHI1 added,and the inhibition mechanism of GHI1 was discussed.The results show that PVP and GHI1 could effectively inhibit the growth of gas hydrates but not nucleation.Under the experimental condition with PVP added,methane and ethane occupied the small cavities of the hydrate crystal unit and the ability of ethane entering into hydrate cavities was weaker than that of methane.GHI1 could effectively inhibit molecules which could more readily form hydrates.The ether and hydroxy group of diethylene glycol monobutyl ether have the responsibility for stronger inhibition ability of GHI1 than PVP. | TANG CuiPing 1,2,DAI XingXue 1,2,DU JianWei 1,2,LI DongLiang 1,2,ZANG XiaoYa 1,2,YANG XiangYang 1 & LIANG DeQing 1 1 Guangzhou Institute of Energy Conversion,Key Laboratory of Renewable Energy and Gas Hydrate,Chinese Academy of Sciences,Guangzhou 510640,China 2 Graduate University of the Chinese Academy of Sciences,Beijing 100039,China | 2010 | Science China Chemistry2010，53，12： | 9 |
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