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| 1 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 2 | Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp显示文摘Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation,and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues.The aim of this study was to investigate the role and the underlying molecular mechanisms of Dlx2 in osteogenic differentiation of mouse bone marrow stromal cells (BMSCs) and pre-osteoblast MC3T3-E1 cells.Initially,we observed upregulation of Dlx2 during the early osteogenesis in BMSCs and MC3T3-E1 cells.Moreover,Dlx2 overexpression enhanced alkaline phosphatase (ALP) activity and extracellular matrix mineralization in BMSCs and MC3T3-E1 cell line.In addition,micro-CT of implanted tissues in nude mice confirmed that Dlx2 overexpression in BMSCs promoted bone formation in vivo.Unexpectedly,Dlx2 overexpression had little impact on the expression level of the pivotal osteogenic transcription factors Runx2,Dlx5,Msx2,and Osterix,but led to upregulation of Alp and Osteocalcin (OCN),both of which play critical roles in promoting osteoblast maturation.Importantly,luciferase analysis showed that Dlx2 overexpression stimulated both OCN and Alp promoter activity.Through chromatin-immunoprecipitation assay and site-directed mutagenesis analysis,we provide molecular evidence that Dlx2 transactivates OCN and Alp expression by directly binding to the Dlx2-response cis-acting elements in the promoter of the two genes.Based on these findings,we demonstrate that Dlx2 overexpression enhances osteogenic differentiation in vitro and accelerates bone formation in vivo via direct upregulation of the OCN and Alp gene,suggesting that Dlx2 plays a crucial role in osteogenic differentiation and bone formation. | Jianfei Zhang Wenbin Zhang Jiewen Dai Xudong Wang Steve Guofang Shen | 2019 | International Journal of Oral Science2019，11，2： | 19 |
| 3 | A Comprehensive Overview of Cyber-Physical Systems: From Perspective of Feedback System显示文摘Cyber-physical systems(CPS) are characterized by integrating cybernetic and physical processes. The theories and applications of CPS face the enormous challenges. The aim of this paper is to provide a latest understanding of this emerging multi-disciplinary methodology. First, the features of CPS are described, and the research progresses are summarized from different components in CPS, such as system modeling,information acquisition, communication, control and security.Each part is also followed by the future directions. Then some typical applications are given to show the prospects of CPS. | Xinping Guan Bo Yang Cailian Chen Wenbin Dai Yiyin Wang | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，1： | 14 |
| 4 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 5 | The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma显示文摘Chimeric antigen receptor T(CAR T)cell therapy has demonstrated efficacy in the treatment of haematologic malignancies.However,the accompanying adverse events,the most common of which is cytokine release syndrome(CRS),substantially limit its wide application.Due to its unique physiological characteristics,CRS in CAR T-cell treatment for B-cell non-Hodgkin lymphoma(BNHL)may exhibit some special features.Although existing guidelines had greatly promoted the recognition and management of CRS,many recommendations are not fully applicable to B-NHL.Therefore,it is imperative to identify responses that are specific to CRS observed following CAR T treatment for B-NHL.Based on underlying biological processes and known pathophysiological mechanisms,we tentatively propose a new model to illustrate the occurrence and evolution of CAR T-cell-therapy-related CRS in BNHL.In this model,tumour burden and bone marrow suppression are considered determinants of CRS.Novel phenomena after CAR T-cell infusion(such as local inflammatory response)are further identified.The proposed model will help us better understand the basic biology of CRS and recognize and manage it more rationally. | Jianshu Wei Yang Liu Chunmeng Wang Yajing Zhang Chuan Tong Guanghai Dai Wei Wang John E.J.Rasko J.Joseph Melenhorst Wenbin Qian Aibin Liang Weidong Han | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 6 | One cell at a time:droplet-based microbial cultivation,screening and sequencing显示文摘Microbes thrive and,in turn,influence the earth's environment,but most are poorly understood because of our limited capacity to reveal their natural diversity and function.Developing novel tools and effective strategies are critical to ease this dilemma and will help to understand their roles in ecology and human health.Recently,droplet microfluidics is emerging as a promising technology for microbial studies with value in microbial cultivating,screening,and sequencing.This review aims to provide an overview of droplet micro flu idics techniques for microbial research.First,some critical points or steps in the microfluidic system are introduced,such as droplet stabilization,manipulation,and detection.We then highlight the recent progress of droplet-based methods for microbiological applications,from high-throughput single-cell cultivation,screening to the targeted or whole-genome sequencing of single cells. | Beiyu Hu Peng Xu Liang Ma Dongwei Chen Jian Wang Xin Dai Li Huang Wenbin Du | 2021 | Marine Life Science & Technology2021，3，2： | 2 |
| 7 | Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity显示文摘Triple-negative breast cancer(TNBC)is the most challenging subtype of breast cancer.Various endeavor has been made to explore the molecular biology basis of TNBC.Herein,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in TNBC.KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor prognosis.In functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and invasiveness.RNA-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further experiments.CXCL8 depletion inhibited the tumorigenesis and progression of TNBC.Additionally,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in vivo.Furthermore,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of cells.Moreover,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 protein.Taken together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and progression.KTN1 may be a potential molecular target for the development of TNBC treatment. | Lin Gao Shanze Chen Malin Hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang Hsien-Da Huang Xiang Gao Chang Zou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 8 | Optimal model establishment of whole-process management data for CAR-T therapy in China—how should this be done?显示文摘Chimeric antigen receptor(CAR)T-cell therapy utilizes patients’own T lymphocytes that are engineered to attack cancer cells[1,2,3].With the US Food and Drug Administration(FDA)approval of four CD19-and one BCMA-targeted CAR therapy for B cell malignancies[4,5],CAR T-cell therapy has finally reached the status of a medicinal product. | Xiaolei Li Hanren Dai Xian Li Ping Li Wenbin Qian Aibin Liang Weidong Han | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 9 | Oxidation behavior of magnesium aluminum oxynitride显示文摘 | Dai Wenbin | 2007 | J Ceram Soc Japan2007，115，139： | 1 |
| 10 | Oxidation behavior of magnesium aluminum oxynitride显示文摘 | Dai Wenbin Yamaguchi A Lin Wei | 2007 | Journal of the Ceramic Society of Japan2007，115，6： | 1 |
| 11 | Exploring the diversity of plant proteome显示文摘The tremendous functional,spatial,and temporal diversity of the plant proteome is regulated by multiple factors that continuously modify protein abundance,modifications,interactions,localization,and activity to meet the dynamic needs of plants.Dissecting the proteome complexity and its underlying genetic variation is attracting increasing research attention.Mass spectrometry(MS)‐based proteomics has become a powerful approach in the global study of protein functions and their relation-ships on a systems level.Here,we review recent breakthroughs and strategies adopted to unravel the diversity of the proteome,with a specific focus on the methods used to analyze posttranslational modifications(PTMs),protein localization,and the organization of proteins into functional modules.We also consider PTM crosstalk and multiple PTMs temporally regulating the life cycle of proteins.Fi-nally,we discuss recent quantitative studies using MS to measure protein turnover rates and examine future directions in the study of the plant proteome. | Yanmei Chen Yi Wang Jun Yang Wenbin Zhou Shaojun Dai | 2021 | Journal of Integrative Plant Biology2021，63，7： | 1 |
| 12 | Simultaneous Determination of Amoxicillin and Ampicillin in Eggs by Reversed-Phase High-Performance Liquid Chromatography with Fluorescence Detection using Pre-Column Derivatization显示文摘 | Kaizhou Xie Longfei Jia Dong Xu Huisheng Guo Xing Xie Yuping Huang Xuesen Chen Wenbin Bao Guojun Dai Jinyu Wang | 2012 | Journal of Chromatographic Science2012，，7： | 1 |
| 13 | 显示文摘 | Dai Wenbin Wei lin Yu Jingkun | 2006 | Journal of the Technical Association of Refractories2006，26，3： | 1 |
| 14 | Electroless preparation and characterization of magnetic ICF PS targets显示文摘 | Yang Wenbin Zhang Bingjie Dai Yatang | 2008 | Fusion Engineering and Design2008，83，56： | 1 |
| 15 | Ultra-antifreeze,ultra-stretchable,transparent,and conductive hydrogel for multi-functional flexible electronics as strain sensor and triboelectric nanogenerator显示文摘Conductive hydrogels have become one of the most promising candidates for flexible electronics due to their excellent mechanical flexibility,durability of deformation,and good electrical conductivity.However,in real applications,severe environments occur frequently,such as extremely cold weather.General hydrogels always lack anti-freeze and anti-dehydration abilities.Consequently,the functions of electronic devices based on traditional hydrogels will quickly fail in extreme environments.Therefore,the development of environmentally robust hydrogels that can withstand extremely low temperatures,overcome dehydration,and ensure the stable operation of electronic devices has become increasingly important.Here,we report a kind of graphene oxide(GO)incorporated polyvinyl alcohol-polyacrylamide(PVA-PAAm)double network hydrogel(GPPDhydrogel)which shows excellent anti-freeze ability.The GPPD-hydrogel exhibits not only good flexibility and ultra-high stretchability up to 2,000%,but ensures a high sensitivity when used as the strain sensor at−50°C.More importantly,when serving as the electrode of a sandwich-structural triboelectric nanogenerator(TENG),the GPPD-hydrogel endows the TENG high and stable output performances even under−80°C.Besides,the GPPD-hydrogel is demonstrated long-lasting moisture retention over 100 days.The GPPD-hydrogel provides a reliable and promising candidate for the new generation of wearable electronics. | Xinhuan Dai Yong Long Bing Jiang Wenbin Guo Wei Sha Jiangwen Wang Zifeng Cong Jiwei Chen Bingjun Wang Weiguo Hu | 2022 | Nano Research2022，15，6： | 1 |
| 16 | Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: A protective role for topiramate 显示文摘 | Follett PL Wenbin Deng Weimin Dai | 2004 | The Journal of Neuroscience2004，24，： | 1 |
| 17 | Electroless preparation and characterization of magnetic ICF PS targets显示文摘 | Yang Wenbin Zhang Bingjie Dai Yatang | 2008 | Fusion Engineering and Design2008，83，： | 1 |
| 18 | Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies显示文摘This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses. | Xueling Suo Du Lei Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong | 2021 | Frontiers of Medicine2021，15，1： | 0 |
| 19 | Bioadaptable bioactive glass-β-tricalcium phosphate scaffolds with TPMS-gyroid structure by stereolithography for bone regeneration显示文摘Bone defect repair remains a troubling problem in clinical orthopedics,which involves complex biological processes.Calcium phosphates(CaPs)have been widely used owing to their advantage of biocompatibility.However,single component and traditional fabrication methods cannot meet the requirements of bioadaptability during the tissue repair process.In this work,0%,5%,15%,25%wt%of BG-TCP(bioactive glass-β-tricalcium phosphate)bioresorbable scaffolds with triply-periodic minimal surfaces(TPMS)-gyroid structure were prepared by the stereolithography(SLA)technology.TPMS-gyroid structure provided an accurate mimicry of natural bone tissue,and the incorporation of BG improved the compressive strength ofβ-TCP matrix,matched with the defective bone(2–12 MPa).Rapid but tunable degradation kinetics(compared with pure TCP)of BG enabled the BG-TCP system to sh8ow adaptable biodegradability to new bone generation.In vitro studies have shown that composite scaffolds have better mechanical properties(7.82 MPa),and can released appropriate contents of calcium,phosphorous,and magnesium ions,which promoted the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)and angiogenic ability of endothelial progenitor cells(EPCs).Moreover,the in vivo assessment of rat femoral defect revealed that TPMS-structure-based TCP scaffolds accelerated bone ingrowth to the pores.Moreover,BG-TCP scaffolds,especially 15BG-TCP group,exhibited superior bone regeneration capacity at both 4 and 8 weeks,which achieved an optimal match between the rate of material degradation and tissue regeneration.In summary,this study provides insight into influences of bioactive components(BG)and bionic structures(TPMS)on the physical-chemical properties of materials,cell behavior and tissue regeneration,which offers a promising strategy to design bioadaptive ceramic scaffolds in the clinical treatment of bone defects. | Meng Li Jiawei Jiang Wenbin Liu Xiaolong Huang Xiaopei Wu Wenying Wei Hao Zhu Jinyong Zhang Jun Xiao Honglian Dai | 2023 | Journal of Materials Science & Technology2023，，24： | 0 |
| 20 | IbNIEL-mediated degradation of IbNAC087 regulates jasmonic acid-dependent salt and drought tolerance in sweet potato显示文摘Sweet potato(Ipomoea batatas[L.]Lam.)is a crucial staple and bioenergy crop.Its abiotic stress tolerance holds significant importance in fully utilizing marginal lands.Transcriptional processes regulate abiotic stress responses,yet the molecular regulatory mechanisms in sweet potato remain unclear.In this study,a NAC(NAM,ATAF1/2,and CUC2)transcription factor,IbNAC087,was identified,which is commonly upregulated in salt-and drought-tolerant germplasms.Overexpression of IbNAC087 increased salt and drought tolerance by increasing jasmonic acid(JA)accumulation and activating reactive oxygen species(ROS)scavenging,whereas silencing this gene resulted in opposite phenotypes.JA-rich IbNAC087-OE(overexpression)plants exhibited more stomatal closure than wild-type(WT)and IbNAC087-Ri plants under NaCl,polyethylene glycol,and methyl jasmonate treatments.IbNAC087 functions as a nuclear transcriptional activator and directly activates the expression of the key JA biosynthesisrelated genes lipoxygenase(IbLOX)and allene oxide synthase(IbAOS).Moreover,IbNAC087 physically interacted with a RING-type E3 ubiquitin ligase NAC087-INTERACTING E3 LIGASE(IbNIEL),negatively regulating salt and drought tolerance in sweet potato.IbNIEL ubiquitinated IbNAC087 to promote 26S proteasome degradation,which weakened its activation on IbLOX and IbAOS.The findings provide insights into the mechanism underlying the IbNIEL-IbNAC087 module regulation of JA-dependent salt and drought response in sweet potato and provide candidate genes for improving abiotic stress tolerance in crops. | Xu Li Zhen Wang Sifan Sun Zhuoru Dai Jun Zhang Wenbin Wang Kui Peng Wenhao Geng Shuanghong Xia Qingchang Liu Hong Zhai Shaopei Gao Ning Zhao Feng Tian Huan Zhang Shaozhen He | 2024 | Journal of Integrative Plant Biology2024，66，2： | 0 |
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