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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | The signal pathways and treatment of cytokine storm in COVID-19显示文摘The Coronavirus Disease 2019(COVID-19)pandemic has become a global crisis and is more devastating than any other previous infectious disease.It has affected a significant proportion of the global population both physically and mentally,and destroyed businesses and societies.Current evidence suggested that immunopathology may be responsible for COVID-19 pathogenesis,including lymphopenia,neutrophilia,dysregulation of monocytes and macrophages,reduced or delayed type I interferon(IFN-I)response,antibody-dependent enhancement,and especially,cytokine storm(CS).The CS is characterized by hyperproduction of an array of pro-inflammatory cytokines and is closely associated with poor prognosis.These excessively secreted pro-inflammatory cytokines initiate different inflammatory signaling pathways via their receptors on immune and tissue cells,resulting in complicated medical symptoms including fever,capillary leak syndrome,disseminated intravascular coagulation,acute respiratory distress syndrome,and multiorgan failure,ultimately leading to death in the most severe cases.Therefore,it is clinically important to understand the initiation and signaling pathways of CS to develop more effective treatment strategies for COVID-19.Herein,we discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines involved.We also discuss the induction,function,downstream signaling,and existing and potential interventions for targeting these cytokines or related signal pathways.We believe that a comprehensive understanding of CS in COVID-19 will help to develop better strategies to effectively control immunopathology in this disease and other infectious and inflammatory diseases. | Lan Yang Xueru Xie Zikun Tu Jinrong Fu Damo Xu Yufeng Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 7 |
| 3 | Administration of exogenous interleukin - 18 and interleukin - 12 prevents the induction of oral tolerance显示文摘 | Eaton A D Xu Damo Garside P | 2003 | Immunologe2003，108，19： | 1 |
| 4 | Beneficial arthropods regulating population of insect pests on cotton显示文摘 | Cacayorin N D Solsoloy A D Damo M C | 1993 | Cotton Res (Philippines)1993，6，： | 1 |
| 5 | Temporal lobe dysfunction and correlation of regional cerebral blood flow abnormalities with psychopathology in schizophrenia and major depression-a study with single photon emission computed tomography显示文摘 | Klemm E Damos P Grnwald F | 1996 | Psychiatry Res1996，68，： | 1 |
| 6 | Development and statistical evaluation of models in forecasting moth phenology of major lepidopterous peach pest complex for Integrated Pest Management programs显示文摘 | Petros T. Damos Matilda Savopoulou-Soultani | 2010 | Crop Protection2010，，10： | 1 |
| 7 | Beneficialarthropods regulating population of insect pests on cotton显示文摘 | CACAYORIN N D SOLSOLOY A D DAMO M C | 1993 | Cotton Res (Philippines)1993，6，： | 1 |
| 8 | Pulsatile Vesus steady component of blood pressure: a cross-sectional analysis and a prospective analysis on cardiovascular mortality显示文摘 | Damo B Gierd X Safer M | 1998 | Hypertension1998，13，： | 1 |
| 9 | IL-33 reduces the devel- opment of atherosclerosis 显示文摘 | Miller AM Damo X Asquith DL | 2008 | J Exper Med2008，205，2： | 1 |
| 10 | Pilot selection batteries: shortcomings and perspectives显示文摘 | Damos DL | 1996 | Int J Aviat Psychol1996，6，2： | 1 |
| 11 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 12 | Voltammetric determination of 4-nitrophenol at a lithium tctracyanocthylenide (LiTCNE)modified glassy carbon electrode显示文摘 | Luz R Damos F Oliveim A | 2004 | Talanta2004，64，： | 1 |
| 13 | Electrochemical properties of self-assembled monolayer based on mono-(6-deoxy-6-mercapto)- βcyclodextrin toward controlled molecular recognition 显示文摘 | F S Damos R Luz L T Kubota | 2006 | Electrochimica Acta2006，53，4： | 1 |
| 14 | Temporal lobe dysfunction and correlation of regional cerebral blood folw abnormalities with psychopathology in schizophrenia and major depression-a study with single photon emission computed tomography显示文摘 | Klemm E Damos P Grunwald F | 2006 | Psychiatry Res2006，68，： | 1 |
| 15 | Phase H study of sor- afenib in patients with metastatic or recurrent sarcomas显示文摘 | Maki RG D~damo DR Keohan ML | 2009 | J Clin Oncol2009，27，19： | 1 |
| 16 | Development and statis- tical evaluation of models in forecasting moth phenology of ma- jor Lepidopterous peach pest complex for integrated pest man- agement programs 显示文摘 | Damos P T Savopoulou - Soultani M | 2010 | Crop Protection2010，29，10： | 1 |
| 17 | Protective Immune Responses Induced by Vaccination with an Expression Genomic Library of Leishmania major 显示文摘 | David P Damo X David H | 1999 | The Journal of Immunology1999，163，： | 1 |
| 18 | High false alarm rates on a vig- ilance task may indicate recreational drug use显示文摘 | DAMOS D L PARKER E S | 1994 | J Clin ExpNeuropsychol1994，16，5： | 1 |
| 19 | Hepatocyte targeted expression by integrase defec- tive lentiviral vectors induces antigen specific tolerance in mice with low genotoxic risk显示文摘 | Mdtrai J Cantore A Bartholomae C C Annoni A Wang W Acosta-Sanchez A Samara-Kuko E De Waele L Ma L Genovese P Damo M Arens A Goudy K Nichols T C yon Kalle C Chuah M K L Roncarolo M G Schmidt M Driessche T V Naldini L | 2011 | Hepatology2011，53，5： | 1 |
| 20 | T1/ST2-an IL-1 receptor-like modulator of immune responses 显示文摘 | Vladimir T Matthew J S Damo Xu | 2004 | Cytokine Growth Factor Rev2004，15，： | 1 |
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