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| 1 | Biological properties and clinical applications of berberine显示文摘Berberine,an isoquinoline alkaloid isolated from the Chinese herb Coptis chinens is and other Berber is plants,has a wide range of pharmacological properties.Berberine can be used to treat many diseases,such as cancer and digestive,metabolic,cardiovascular,and neurological diseases.Berberine has protective capacities in digestive diseases.It can inhibit toxins and bacteria,including Helicobac terpylo riprotect the intestinal epithelial barrier from injury,and ameliorate liver injury.Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis.Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies.In addition,berberine regulates glycometabolism and lipid metabolism,improves energy expenditure,reduces body weight,and alleviates nonalcoholic fatty liver disease.Berberine also improves cardiovascular hemodynamics,suppresses ischemic arrhythmias,attenuates the development of atherosclerosis,and reduces hypertension.Berberine shows potent neuroprotective effects,including antioxidative,antiapoptotic,and anti-ischemic.Furthermore,berberine exerts protective effects against other diseases.The mechanisms of its functions have been extensively explored,but much remains to be clarified.This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive,metabolic,cardiovascular,and neurological diseases. | Danyang Song Jianyu Hao Daiming Fan | 2020 | Frontiers of Medicine2020，14，5： | 30 |
| 2 | Pattern recognition receptors in health and diseases显示文摘Pattern recognition receptors(PRRs)are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens,apoptotic host cells,and damaged senescent cells.PRRs bridge nonspecific immunity and specific immunity.Through the recognition and binding of ligands,PRRs can produce nonspecific anti-infection,antitumor,and other immunoprotective effects.Most PRRs in the innate immune system of vertebrates can be classified into the following five types based on protein domain homology:Toll-like receptors(TLRs),nucleotide oligomerization domain(NOD)-like receptors(NLRs),retinoic acid-inducible gene-1(RIG-1)-like receptors(RLRs),C-type lectin receptors(CLRs),and absent in melanoma-2(AIM2)-like receptors(ALRs).PRRs are basically composed of ligand recognition domains,intermediate domains,and effector domains.PRRs recognize and bind their respective ligands and recruit adaptor molecules with the same structure through their effector domains,initiating downstream signaling pathways to exert effects.In recent years,the increased researches on the recognition and binding of PRRs and their ligands have greatly promoted the understanding of different PRRs signaling pathways and provided ideas for the treatment of immune-related diseases and even tumors.This review describes in detail the history,the structural characteristics,ligand recognition mechanism,the signaling pathway,the related disease,new drugs in clinical trials and clinical therapy of different types of PRRs,and discusses the significance of the research on pattern recognition mechanism for the treatment of PRR-related diseases. | Danyang Li Minghua Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 9 |
| 3 | Prognosis and weaning of elderly multiple organ dysfunction syndrome patients with invasive mechanical ventilation显示文摘 | Xiao Kun Su Longxiang Han Bingchao Guo Chao Feng Lin Jiang Zhaoxu Wang Huijuan Lin Yong Jia Yanhong She Danyang Xie Lixin | 2014 | Chinese Medical Journal2014，，1： | 7 |
| 4 | Study on the Hydrophobic Property of Shark-Skin-Inspired Micro-Riblets显示文摘 | Danyang Zhao Qianqian Tian Minjie Wang Yifei Jin | 2014 | Journal of Bionic Engineering2014，11，2： | 6 |
| 5 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 6 | Freeform OST-HMD system with large exit pupil diameter and vision correction capability显示文摘Compactness and light weight,large exit pupil diameter and distance,small distortion for virtual image,and see-through light paths are pivotal factors to achieve a better,wearable experience of optical see-through headmounted displays(OST-HMDs).In addition,light efficiency of the virtual image light path is an important factor for heat dissipation in HMD devices.This paper presents a new type of OST-HMD optical system that includes three wedge-shaped freeform prisms and two symmetric lenses.Based on a 0.71 in.microdisplay,an OST-HMD prototype with a diagonal field of view(FOV)of 45.3°,an F-number(F/#)of 1.8,an exit pupil size of 12 mm×8 mm,and an eye relief of 18 mm is demonstrated.The maximum value of distortion of the final system is 0.6%and 0.4%for virtual image and see-through light path,respectively.The overall dimension of the optical system per eye is no larger than 30 mm(width)×40 mm(height)×14 mm(thickness),and the weight of the optical module including lenses,holder,and microdisplay is 12.8 g.The light efficiency of the virtual image light path is up to 50%higher than those of other OST-HMD optical solutions. | DEWEN CHENG JIAXI DUAN HAILONG CHEN HE WANG DANYANG LI QIWEI WANG QICHAO HOU TONG YANG WEIHONG HOU DONGHUA WANG XIAOYU CHI BIN JIANG YONGTIAN WANG | 2022 | Photonics Research2022，10，1： | 5 |
| 7 | Synthesis of a reduction-sensitive Bletilla striata polysaccharide amphiphilic copolymer显示文摘Recently, much special attention has been focused on the development of amphiphilic copolymers.Herein, a reduction-sensitive stearic acid grafted-Bletilla striata polysaccharide copolymer(BSP-ss-SA)was synthesized and characterized. BSP-ss-SA copolymer could spontaneously form micelles with an average particle size of(106 ? 4.36) nm. Particle sizes were dramatically larger under 10 mmol/L dithiothreitol(DTT) than that in absence of 10 mmol/L DTT. Docetaxel loading content and encapsulation efficiency of micelles were 5.94 wt% and 72.75 wt%, respectively. The docetaxel release rate in vitro in micelles could be remarkably accelerated in pH 7.4 phosphate buffer solution(PBS) containing 10 mmol/L DTT compared with that of micelles(0 mmol/L DTT). Furthermore, MTT results demonstrated the anticancer activities in vitro of docetaxel-loaded BSP-ss-SA micelles on HepG2 were superior to that of docetaxel injection. BSP-ss-SA copolymer might be a promising nanocarrier for cancer chemotherapy drugs. | Dandan Sun Miao Wang Danyang Ji Jin Qiao Tong He Xin Liu Qingxiang Guan | 2018 | Chinese Chemical Letters2018，29，6： | 5 |
| 8 | In-situ optimizing the valence configuration of vanadium sites in NiV-LDH nanosheet arrays for enhanced hydrogen evolution reaction显示文摘Developing the highly active, cost-effective, environmental-friendly, and ultra-stable nonprecious electrocatalysts for hydrogen evolution reaction(HER) is distinctly indispensable for the large-scale practical applications of hydrolytic hydrogen production. Herein, we report the synthesis of well-integrated electrode, NiV layered double hydroxide nanosheet array grown in-situ on porous nickel foam(abbreviated as in-NiV-LDH/NF) via the facile one-step hydrothermal route. Interestingly, the valence configuration of vanadium(V) sites in such NiV-LDH are well dominated by the innovative use of NF as the reducing regulator, achieving the reassembled in-NiV-LDH/NF with a high proportion of trivalent V ions(V3+), and then an enhanced intrinsic electrocatalytic HER activity. The HER testing results show that the in-NiVLDH/NF drives the current densities of 10 and 100 mA cm-2 at extremely low overpotentials of 114 and 245 mV without iR-compensation respectively, even outperforms commercial 20 wt% Pt/C at the large current density of over 80 mA cm-2 in alkaline media, as well as gives robust catalytic durability of at least 100 h in both alkaline and neutral media. More importantly, this work provides a fresh perspective for designing bimetal(oxy) hydroxides electrocatalysts with efficient hydrogen generation. | Danyang He Liyun Cao Jianfeng Huang Koji Kajiyoshi Jianpeng Wu Changcong Wang Qianqian Liu Dan Yang Liangliang Feng | 2020 | Journal of Energy Chemistry2020，29，8： | 5 |
| 9 | BODIPY-derived ratiometric fluorescent sensors: pH-regulated aggregation-induced emission and imaging application in cellular acidification triggered by crystalline silica exposure显示文摘Modification of classic fluorophore to possess the emission transitions between aggregation-induced emission(AIE)and intrinsic emission offers reliable approach to the design of ratiometric fluorescent sensors.In this study,a proton acceptor benzimidazole was integrated with BODIPY to form three compounds,BBI-1/2/3,which demonstrated the AIE(~595 nm,I_(agg))in neutral aqueous medium and intrinsic BODIPYemission(~510 nm,I_(int))in acidic medium.All the three showed the ratiometric pH sensing behavior in a dual excitation/dual emission mode,yet BBI-3 displayed still the dual emission ratiometric pH sensing ability.The pH-dependent emission ratio I_(int)/I_(agg)of the three were fully reversible,and no interference was observed from normal abundant chemical species in live cells.Their different p K_a(BBI-1,p K_a4.4;BBI-2,p K_a2.7;BBI-3,p K_a3.6)suggested that the substituents on benzimidazole moiety were essential to govern their functioning pH range.The ratiometric imaging of BBI-1 in A549 cells provided an effective intracellular pH(pH_i)calibration formula corresponding to emission ratio of I_(int)/I_(agg).Ratiometric pH_iimaging in A549 cells upon small particle exposure confirmed the particle-induced cellular acidification with this formula.Both particle size and the chemical nature of the particle contribute to the observed acidification effect.The synchronization of lysosome disruption to cellular acidification in A549 cells upon crystalline silica exposure was directly observed for the first time with BBI-1,showing the potential application of BBI-1 in the study of silicosis and other related diseases.This study demonstrated that endowing fluorophore with AIE/intrinsic emission transition could be a promising strategy for ratiometric sensor design. | Yang Bai Danyang Liu Zhong Han Yuncong Chen Zhongyan Chen Yang Jiao Weijiang He Zijian Guo | 2018 | Science China Chemistry2018，61，11： | 4 |
| 10 | PCL2 regulates p53 stability and functions as a tumor suppressor in breast cancer显示文摘Polycomblike2(PCL2) is a well-known component of polycomb repressive complex 2(PRC2) and plays important roles in H3 K27 methylation and homeotic gene silencing.However,the involvement of PCL2 in breast cancer development remains unclear.Here,we established PCL2 as a tumor suppressor gene in breast cancer.Expression level of PCL2 was significantly downregulated in breast cancer tissue samples observed at different TNM stages.Ectopic expression of PCL2 could significantly inhibit cell proliferation and promoted apoptosis.PCL2 also remarkably elevated levels of p53 and its targets by increasing p53 stability.Mechanistically,PCL2 protected p53 proteins from MDM2-mediated ubiquitination and degradation by sequestering MDM2 into the nucleolus.Overexpression of PCL2 also suppressed migration and invasion by inhibiting epithelial-mesenchymal transition.PCL2 expression was correlated with Ecadherin expression and was inversely correlated with vimentin expression.Furthermore,PCL2 knockdown could attenuate anti-tumor effect of MLN4924.Taken together,our findings indicated that PCL2 played a tumor suppressor role in development and progression of breast cancer and may be a prognostic and predictive marker for breast cancer. | Yiran Liang Yang Yang Renbo Guo Shuang Gao Xinghong Guo Danyang Li Meng Wang Haruhiko Koseki Xiangzhi Li | 2018 | Science Bulletin2018，63，10： | 4 |
| 11 | Pulsed Nd:YAG laser cladding of high silicon content coating on low silicon steel显示文摘A pulsed Nd:YAG (yttrium aluminum garnet) laser-based technique was employed to clad low silicon steel with preplaced Si and Fe mixed powders for high Si content. The surface morphology, microstructural evolution, phase composition, and Si distribution, within the obtained cladding coatings, were characterized by optical microscopy (OM), field emission scanning electron microscopy (FE-SEM), with associated energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The microhardness was also measured along the depth direction of the specimens. A crack-and pore-free cladding coating through excellent metallurgical bonding with the substrate was successfully prepared on low silicon steel by means of optimized sin-gle-track and multi-track laser cladding. The phases of the coating are α-Fe, γ-Fe, and FeSi. The high microhardness of the la-ser-cladding zone is considered as an increase in Si content and as the refined microstructure produced by the laser treatment. The Si contents of the cladding coatings were about 5.8wt/ in the single-track cladding and 6.5wt/ in the multi-track cladding, respectively. | Danyang Dong Changsheng Liu Bin Zhang Jun Miao | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 4 |
| 12 | Oxide-based cathode materials for rechargeable zinc ion batteries:Progresses and challenges显示文摘With the increasing demands for electrical energy storage technologies,rechargeable zinc ion batteries(ZIBs)have been rapidly developed in recent years owing to their high safety,low cost and high energy storage capability.The cathode is an essential part of ZIBs,which hosts zinc ions and determines the capacity,rate and cycling performance of the battery.The mainstream cathodes for ZIBs are oxidebased materials with tunnel,layer or 3 D crystal structures.In this review,we mainly focus on the latest advanced oxide-based cathode materials in ZIBs,including manganese oxides,vanadium oxides,spinel compounds,and other metal oxide based cathodes.In addition,the mechanisms of zinc storage and recent development in cathode design have been discussed in detail.Finally,current challenges and perspectives for the future research directions of oxide-based cathodes in ZIBs are presented. | Yingze Zhou Fandi Chen Hamidreza Arandiyan Peiyuan Guan Yunjian Liu Yuan Wang Chuan Zhao Danyang Wang Dewei Chu | 2021 | Journal of Energy Chemistry2021，30，6： | 4 |
| 13 | Investigation of Knowledge Transfer Approaches to Improve the Acoustic Modeling of Vietnamese ASR System显示文摘It is well known that automatic speech recognition(ASR) is a resource consuming task. It takes sufficient amount of data to train a state-of-the-art deep neural network acoustic model. As for some low-resource languages where scripted speech is difficult to obtain, data sparsity is the main problem that limits the performance of speech recognition system. In this paper, several knowledge transfer methods are investigated to overcome the data sparsity problem with the help of high-resource languages.The first one is a pre-training and fine-tuning(PT/FT) method, in which the parameters of hidden layers are initialized with a welltrained neural network. Secondly, the progressive neural networks(Prognets) are investigated. With the help of lateral connections in the network architecture, Prognets are immune to forgetting effect and superior in knowledge transferring. Finally,bottleneck features(BNF) are extracted using cross-lingual deep neural networks and serves as an enhanced feature to improve the performance of ASR system. Experiments are conducted in a low-resource Vietnamese dataset. The results show that all three methods yield significant gains over the baseline system, and the Prognets acoustic model performs the best. Further improvements can be obtained by combining the Prognets model and bottleneck features. | Danyang Liu Ji Xu Pengyuan Zhang Yonghong Yan | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，5： | 4 |
| 14 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
| 15 | Progress and key challenges in catalytic combustion of lean methane显示文摘As a primary type of clean energy,methane is also the second most important greenhouse gas after CO_(2)due to the high global warming potential.Large quantities of lean methane(0.1–1.0 vol%)are emitted into the atmosphere without any treatment during coal mine,oil,and natural gas production,thus leading to energy loss and greenhouse effect.In general,it is challenging to utilize lean methane due to its low concentration and flow instability,while catalytic combustion is a vital pathway to realize an efficient utilization of lean methane owing to the reduced emissions of polluting gases(e.g.,NOxand CO)during the reaction.In particular,to efficiently convert lean methane,it necessitates both the designs of highly active and stable heterogeneous catalysts that accelerate lean methane combustion at low temperatures and smart reactors that enable autothermal operation by optimizing heat management.In this review,we discuss the in-depth development,challenges,and prospects of catalytic lean methane combustion technology in various configurations,with particular emphasis on heat management from the point of view of material design combined with reactor configuration.The target is to describe a framework that can correlate the guiding principles among catalyst design,device innovation and system optimization,inspiring the development of groundbreaking combustion technology for the efficient utilization of lean methane. | Xiangbo Feng Lei Jiang Danyang Li Shaopeng Tian Xing Zhu Hua Wang Chi He Kongzhai Li | 2022 | Journal of Energy Chemistry2022，，12： | 4 |
| 16 | Accurate machine learning models based on small dataset of energetic materials through spatial matrix featurization methods显示文摘A large database is desired for machine learning(ML) technology to make accurate predictions of materials physicochemical properties based on their molecular structure.When a large database is not available,the development of proper featurization method based on physicochemical nature of target proprieties can improve the predictive power of ML models with a smaller database.In this work,we show that two new featurization methods,volume occupation spatial matrix and heat contribution spatial matrix,can improve the accuracy in predicting energetic materials' crystal density(ρ_(crystal)) and solid phase enthalpy of formation(H_(f,solid)) using a database containing 451 energetic molecules.Their mean absolute errors are reduced from 0.048 g/cm~3 and 24.67 kcal/mol to 0.035 g/cm~3 and 9.66 kcal/mol,respectively.By leave-one-out-cross-validation,the newly developed ML models can be used to determine the performance of most kinds of energetic materials except cubanes.Our ML models are applied to predict ρ_(crystal) and H_(f,solid) of CHON-based molecules of the 150 million sized PubChem database,and screened out 56 candidates with competitive detonation performance and reasonable chemical structures.With further improvement in future,spatial matrices have the potential of becoming multifunctional ML simulation tools that could provide even better predictions in wider fields of materials science. | Chao Chen Danyang Liu Siyan Deng Lixiang Zhong Serene Hay Yee Chan Shuzhou Li Huey Hoon Hng | 2021 | Journal of Energy Chemistry2021，30，12： | 4 |
| 17 | Neural cell injury microenvironment induces neural differentiation of human umbilical cord mesenchymal stem cells显示文摘 | Jin Zhou Guoping Tia Jinge Wang Xiaoguang Luo Siyang Zhang Jianping Li Li Li Bing Xu FengZhu Xia Wang Chunhong Jia Weijin Zhao Danyang Zhao Aihua Xu | 2012 | Neural Regeneration Research2012，7，34： | 3 |
| 18 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 19 | MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling显示文摘白 adipocytes 玩在许多生理的过程的重要角色包括精力存储,内分泌的发信号,并且煽动性的回答。理解 adipocyte 形成(adipogenesis ) 的分子的机制对肥胖和它的相关疾病提供卓见进治疗学的途径。许多 transcriptional 因素和 epigenetic 酶被知道调整 adipogenesis;然而, histone 变体是否在这个过程起一个作用,是未知的。这里,我们发现了那 macroH2A1.1 (mH2A1.1 ) , histone H2A 的变体,在在 3T3-L1 房间并且在肥胖的鼠标的白脂肪质的织物的 adipocyte 区别期间是 upregulated。mH2A1.1 的脱离激活表明小径的 Wnt/-catenin,当 mH2A1.1 的 overexpression 出现在效果对面时。我们进一步发现 mH2A1.1 调整了由与 EZH2 合作表明小径的 Wnt/-catenin, histone H3K27 methyltransferase,因此在 Wnt 基因的倡导者上导致了 H3K27me2 和 H3K27me3 的累积。在宏域的变化, mH2A1.1 G224E , 和 mH2A1.1 G314E , 不仅损害了 adipogenesis,而且在 Wnt 基因的倡导者上损害了 mH2A1.1 的有约束力的能力到 EZH2 和 H3K27me2 和 H3K27me3 的丰富。一起,我们的学习在 adipogenesis 和肥胖揭示 mH2A1.1 的一个新奇规章的角色,它在白胖开发提供新卓见。 | Danyang Wan Chengyu Liu Yu Sun Wenjun Wang Kun Huang Ling Zheng | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 20 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
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