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| 1 | A nowcasting model for the prediction of typhoon tracks based on a long short term memory neural network显示文摘It is of vital importance to reduce injuries and economic losses by accurate forecasts of typhoon tracks. A huge amount of typhoon observations have been accumulated by the meteorological department, however, they are yet to be adequately utilized. It is an effective method to employ machine learning to perform forecasts. A long short term memory(LSTM) neural network is trained based on the typhoon observations during 1949–2011 in China's Mainland, combined with big data and data mining technologies, and a forecast model based on machine learning for the prediction of typhoon tracks is developed. The results show that the employed algorithm produces desirable 6–24 h nowcasting of typhoon tracks with an improved precision. | GAO Song ZHAO Peng PAN Bin LI Yaru ZHOU Min XU Jiangling ZHONG Shan SHI Zhenwei | 2018 | Acta Oceanologica Sinica2018，37，5： | 17 |
| 2 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 3 | Field experimental study on pullout forces of rice seedlings and barnyard grasses for mechanical weed control in paddy field显示文摘Pullout forces of rice seedling and barnyard grass were tested by universal testing machine controlled by WDW-5 type microcomputer to obtain the pullout forces of rice seedling and barnyard grass.The measured pullout force was used to improve the weeding rate and reduce the rice seedling damage rate caused by mechanical weeding device.According to the measured continuous curve of pullout forces of rice seeding and barnyard grasses in weeding period,the best range of force required to pull out barnyard grasses from soil with no injury and damage to rice seedlings was discussed.Reasons for the difference in the pulling force were analyzed.Results show that,with the increment of the number of single cell rice seedlings the pullout force increases.The pullout forces of single cell rice seedlings and barnyard grasses at first increased slowly reaching the maximum value followed by rapid drop and finally it remained steady.The minimum pullout forces recorded during rice seedlings at the first and the second weeding periods were 2.57 N and 9.70 N,respectively,while the minimum forces during the first and second weeding periods were recorded as 1.24 N and 7.51 N,respectively,for barnyard grasses.The results show that the pullout forces of weeding to rice seedlings and barnyard grasses should be within 1.24 N to 2.57 N and 7.51 N to 9.70 N respectively in the first and second weeding periods. | Wang Jinwu Tao Guixiang Liu Yongjun Pan Zhenwei Zhang Chunfeng | 2014 | International Journal of Agricultural and Biological Engineering2014，7，6： | 4 |
| 4 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
| 5 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 6 | Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection显示文摘Bitter receptors function primarily in sensing taste,but may also have other functions,such as detecting pathogenic organisms due to their agile response to foreign objects.The mouse taste receptor type-2 member 138(TAS2R138)is a member of the G-protein-coupled bitter receptor family,which is not only found in the tongue and nasal cavity,but also widely distributed in other organs,such as the respiratory tract,gut,and lungs.Despite its diverse functions,the role of TAS2R138 in host defense against bacterial infection is largely unknown.Here,we show that TAS2R138 facilitates the degradation of lipid droplets(LDs)in neutrophils during Pseudomonas aeruginosa infection through competitive binding with PPARG(peroxisome proliferator-activated receptor gamma)antagonist:A/-(3-oxododecanoyl)-L-homoserine lactone(AHL-12),which coincidently is a virulence-bound signal produced by this bacterium(P.aeruginosa).The released PPARG then migrates from nuclei to the cytoplasm to accelerate the degradation of LDs by binding PLIN2(perilipin-2).Subsequently,the TAS2R138-AHL-12 complex targets LDs to augment their degradation,and thereby facilitating the clearance of AHL-12 in neutrophils to maintain homeostasis in the local environment.These findings reveal a crucial role for TAS2R138 in neutrophil-mediated host immunity against P.aeruginosa infection. | Qinqin Pu Kai Guo Ping Lin Zhihan Wang Shugang Qin Pan Gao Colin Combs Nadeem Khan Zhenwei Xia Min Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 7 | Large-conductance Ca^2+-activated K^+ currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells 显示文摘 | Benzhi Caia Dongmei Gong a Zhenwei Pan | 2007 | Life Sciences2007，80，22： | 1 |
| 8 | The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes显示文摘 | Chaoqian Xu Yanjie Lu Zhenwei Pan Wenfeng Chu Xiaobin Luo Huixian Lin Jiening Xiao Hongli Shan Zhiguo Wang and Baofeng Yang | | Journal of Cell Science0，120，17： | 1 |
| 9 | Mi- croRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ os- teosarcoma oncogene/transforming growth factor-E1 pathway显示文摘 | ZHENWEI PAN Z SUN X SHAN H | 2012 | Circulation2012，126，： | 1 |
| 10 | Prevention and control measures of the major cold-region diseases (hypertension) in China显示文摘Hypertension is the most common cardiovascular condition in clinical practice and a major risk factor for stroke and cardiovascular events.There are more than 270 million hypertension patients in China,and the prevalence of hypertension in the high-latitude cold areas is significantly higher than in the low-latitude warm areas.The unique epidemiological characteristics and risk factors of hypertension in the cold regions of China urge for establishment of the prevention and control system for targeted and more effective management of the condition. | Zhenwei Pan Yong Zhang Tengfei Pan Haihai Liang Baofeng Yang | 2021 | Frigid Zone Medicine2021，1，1： | 1 |
| 11 | Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice显示文摘Methyltransferase-like 3(Mettl3)is a component of methyltransferase complex that mediates m6A modification of RNAs,and participates in multiple biological processes.However,the role of Mettl3 in cardiac electrophysiology remains unknown.This study aims to explore the ventricular arrhythmia susceptibility of Mettl3+/–mice and the underlying mechanisms.Mice were anesthetized with 2%avertin(0.1 mL/10 g body weight)for echocardiography and programmed electrical pacing.Whole-cell patch clamp technique was used to examine the electrophysiological property of cardiomyocytes.The expression of Cav1.2 was determined by qRT-PCR and western blot analysis.The m6A medication of mRNA was examined by MeRIP-Seq and MeRIP-qPCR.No differences are found in the morphology and function of the hearts between Mettl3+/–mice and wild-type(WT)controls.The QT and QTc intervals of Mettl3+/–mice are significantly longer.High-frequency electrical stimulation showed that heterozygous knockout of Mettl3 increases ventricular arrhythmia susceptibility.The whole-cell patch-clamp recordings showed that the APD is prolonged in Mettl3+/–ventricular myocytes and more EADs were observed.The density of ICa-L is substantially increased in ventricular myocytes of Mettl3+/–mice.The pore-forming subunit of L-type calcium channel Cav1.2 is upregulated in Mettl3+/–mice,while the mRNA of its coding gene CACNA1C does not change.MeRIP-Seq and MeRIP-qPCR showed that the m6A methylation of CACNA1C mRNA is decreased in cultured Mettl3-knockdown cardiomyocytes and Mettl3+/–hearts.Collectively,deficiency of Mettl3 increases ventricular arrhythmia susceptibility due to the upregulation of Cav1.2 by reducing m6A modification on CACNA1C mRNA in mice.This study highlights the role of m6A modification in the regulation of cardiac electrophysiology. | Ling Shi Xuexin Jin Zheng Li Rui Gong Yang Guo Jiudong Ma Yang Zhang Benzhi Cai Baofeng Yang Dongmei Gong Zhenwei Pan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 12 | Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1expression and activation of p38-MAPK and ERK1/2显示文摘 | Zhenwei Pan Weiming Zhao Xiangying Zhang | 2011 | British journal of Pharmacology2011，162，3： | 1 |
| 13 | Tanshinone H Aprotects against sudden cardiac death induced by lethal arrhyth-mias via repression of microRNA - 1 显示文摘 | Hongli Shan Xuelian Li Zhenwei Pan | 2009 | Br J Pharmacol2009，158，5： | 1 |
| 14 | iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis显示文摘Currently, there remains a great need to elucidate the molecular mechanism of acute myocardial infarction in order to facilitate the development of novel therapy. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is a member of the ASPP family proteins and an evolutionarily preserved inhibitor of p53 that is involved in many cellular processes, including apoptosis of cancer cells. The purpose of this study was to investigate the possible role of iASPP in acute myocardial infarction. The protein level of iASPP was markedly reduced in the ischemic hearts in vivo and hydrogen peroxide-exposed cardiomyocytes in vitro. Overexpression of iASPP reduced the infarct size and cardiomyocyte apoptosis of mice subjected to 24 h of coronary artery ligation. Echocardiography showed that cardiac function was improved as indicated by the increase in ejection fraction and fractional shortening. In contrast, knockdown of iASPP exacerbated cardiac injury as manifested by impaired cardiac function, increased infarct size, and apoptosis rate. Mechanistically, overexpression of iASPP inhibited, while knockdown of iASPP increased the expressions of p53 and Bax, the key regulators of apoptosis. Taken together, our results suggested that iASPP is an important regulator of cardiomyocyte apoptosis, which represents a potential target in the therapy of myocardial infarction. | Timur Yagudin Yue Zhao Haiyu Gao Yang Zhang Ying Yang Xiaofang Zhang Wenbo Ma Tolessa Muleta Daba Vladimir Ishmetov Kai Kang Baofeng Yang Zhenwei Pan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 1 |
| 15 | Studies on the Aromatic Dihalocarbonyl Ylides and Their Deoxygenation显示文摘The deoxygenation reaction of heptanones, cycloheptanone, cycloheptatrienone or substituted cycloheptatrienone with dihalo-carbene results in carbon monoxide and corresponding halides. The yield of CO produced by 2 , 4 , 6-triphenylcycloheptatrienone is 2.6-3.5 times as high as that produced by the saturated heptanones. The structures, energies, charge distributions, bond orders, and other relative parameters of the dihalocarbonyl glides were calculated by using the SCF-MNDO method. The obtained data reveal that the ylides from cycloheptatrienone have aromatic structure and are different from those produced from saturated cycloheptanone. The reactivities of the dihalocarbonyl ylides are discussed. It is proposed that this aromatic structure should be responsible for the high yield of CO from the reaction of cycloheptatrienone with dihalocarbene. | Huan Zhenwei, Pan Yinming, Qu Xiaosu and Gao Zhenheng (Department of Chemistry, Nankai University, Tianjin) | 1989 | Chemical Research in Chinese Universities1989，5，1： | 0 |
| 16 | Ablation of apoptosis-stimulating of p53 protein 1 protects mice from acute hepatic injury and dysfunction via NF-κB pathway in CCl4-induced hepatotoxicity显示文摘Acute liver injury(ALI)is characterized by apoptosis,inflammation,and oxidative stress,and pathogenic mechanism of ALI is poorly understood.Apoptosis-stimulating of p53 protein 1(ASPP1)is involved in environmental responses,tumor growth,and NF-κB activity,which is of critical importance to ALI.However,the role of ASPP1 in ALI remains largely unexplored.The current study aimed to determine the role of ASPP1 in ALI induced by CCl4 and the underlying mechanism.ASPP1 expression was detected in wild type(WT)mice with ALI induced by CCl4.The function of ASPP1 in ALI induced by CCl4 was investigated using conventional knockout ASPP1 mice.ASPP1 expression significantly increased in ALI mice at 24 hours after CCl4 injection.Deletion of ASSP1 ameliorated apoptosis,inflammation,and necrosis in ALI relative to WT mice.In addition,deficiency of ASPP1 improved liver flood flow as well as ALT and AST levels.The levels of phosphorylated p65 and phosphorylated IκBαwere lower in ASPP1-/-mice than in WT mice with ALI.These results implicate that deletion of ASPP1 may act via inhibition of the NF-кB pathway and protect mice from ALI,which may be a new potential therapeutic target for the treatment of ALI. | Tolessa Muleta Daba Xiang Huang Timur Yagudin Ying Yang Jiangang Wang Xiaoyu Fu Yue Zhao Haiyu Gao Yang Zhou Zhenwei Pan Xiangyu Zhong | 2021 | Frigid Zone Medicine2021，1，1： | 0 |
| 17 | Crystal face dependent intrinsic wettability of metal oxide surfaces显示文摘Knowledge of intrinsic wettability at solid/liquid interfaces at the molecular level perspective is significant in understanding crucial progress in some fields,such as electrochemistry,molecular biology and earth science.It is generally believed that surface wettability is determined by the surface chemical component and surface topography.However,when taking molecular structures and interactions into consideration,many intriguing phenomena would enrich or even redress our understanding of surface wettability.From the perspective of interfacial water molecule structures,here,we discovered that the intrinsic wettability of crystal metal oxide is not only dependent on the chemical components but also critically dependent on the crystal faces.For example,the(1I02)crystal face ofα-Al2O3 is intrinsically hydrophobic with a water contact angle near 90°,while another three crystal faces are intrinsically hydrophilic with water contact angles<65°.Based on surface energy analysis,it is found that the total surface energy,polar component and Lewis base portion of the hydrophobic crystal face are all smaller than the other three hydrophilic crystal faces indicating that they have different surface states.DFT simulation further revealed that the adsorbed interfacial water molecules on each crystal face hold various orientations.Herein,the third crucial factor for surface wettability from the perspective of the molecular level is presented,that is the orientations of adsorbed interfacial water molecules apart from the macro-level chemical component and surface topography.This study may serve as a source of inspiration for improving wetting theoretical models and designing controllable wettability at the molecular/atomic level. | Zhongpeng Zhu Zhenwei Yu Frank FYun Deng Pan Ye Tian Lei Jiang Xiaolin Wang | 2021 | National Science Review2021，8，1： | 0 |
| 18 | Tanshinone IIA Protects against Sudden Cardiac Death Induced by Lethal Arrhythmias via Repression of microRNA-1显示文摘 | Xuelian Li Hongli Shan Li Zhang Zhenwei Pan Yanjie Lv Baofeng Yang | 2008 | 中国药理通讯2008，25，2： | 0 |
| 19 | Hydroxychloroquine induces long QT syndrome by blocking hERG channel显示文摘Objective:In March 2022,more than 600 million cases of Corona Virus Disease 2019(COVID-19)and about 6 million deaths have been reported worldwide.Unfortunately,while effective antiviral therapy has not yet been available,chloroquine(CQ)/hydroxychloroquine(HCQ)has been considered an option for the treatment of COVID-19.While many studies have demonstrated the potential of HCQ to decrease viral load and rescue patients'lives,controversial results have also been reported.One concern associated with HCQ in its clinical application to COVID-19 patients is the potential of causing long QT interval(LQT),an electrophysiological substrate for the induction of lethal ventricular tachyarrhythmias.Yet,the mechanisms for this cardiotoxicity of HCQ remained incompletely understood.Materials and methods:Adult New Zealand white rabbits were used for investigating the effects of HCQ on cardiac electrophysiology and expression of ion channel genes.HEK-293T cells with sustained overexpression of human-ether-a-go-go-related gene(hERG)K+channels were used for whole-cell patch-clamp recordings of hERG K+channel current(IhERG).Quantitative RT-PCR analysis and Western blot analysis were employed to determine the expression of various genes at mRNA and protein levels,respectively.Results:electrocardiogram(ECG)recordings revealed that HCQ prolonged QT and RR intervals and slowed heart rate in rabbits.Whole-cell patch-clamp results showed that HCQ inhibited the tail current of hERG channels and slowed the reactivation process from inactivation state.HCQ suppressed the expression of hERG and hindered the formation of the heat shock protein 90(Hsp90)/hERG complex.Moreover,the expression levels of connexin 43(CX43)and Kir2.1,the critical molecular/ionic determinants of cardiac conduction thereby ventricular arrythmias,were decreased by HCQ,while those of Cav1.2,the main Ca2+handling proteins,remained unchanged and SERCA2a was increased.Conclusion:HCQ could induce LQT but did not induce arrhythmias,and whether it is suitable for the treatment of COVID-19 requires more rigorous investigations and validations in the future. | Xin Zhao Lihua Sun Chao Chen Jieru Xin Yan Zhang Yunlong Bai Zhenwei Pan Yong Zhang Baoxin Li Yanjie Lv Baofeng Yang | 2023 | Frigid Zone Medicine2023，3，2： | 0 |
| 20 | Corrigendum to:iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis显示文摘Acta Biochimica et Biophysica Sinica,30 October 2020,http://gffzzd3cc09b8251d45dfsbpc6ofnp6ppn69uu.ffgz.tsg.suse.edu.cn/10.1093/abbs/gmaal04 Following the publication of this article,the authors notified the journal they had neither labeled the bottom images in Fig.5.as Fig.5G,nor included information about these images in the figure caption.In addition,the authors had provided the journal with the wrong representative images of the NC and SI groups.The corrected figure and caption appear below,and the authors apologize for these errors. | Timur Yagudin Yue Zhao Haiyu Gao Yang Zhang Ying Yang Xiaofang Zhang Wenbo Ma Tolessa Muleta Daba Vladimir Ishmetov Kai Kang Baofeng Yang Zhenwei Pan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
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