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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘 | Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella | 2003 | Hypertension: Journal of The American Heart Association2003，，6： | 4 |
| 3 | Management of ventricular tachycardia storm in patients with structural heart disease显示文摘Electrical storm(ES) is a medical emergency characterized by repetitive episodes of sustained ventriculararrhythmias(VAs) in a limited amount of time(at least 3 within a 24-h period) leading to repeated appropriate implantable cardioverter defibrillator therapies. The occurrence of ES represents a major turning point in the natural history of patients with structural heart disease being associated with poor short-and longterm survival particularly in those with compromised left ventricular ejection fraction(LVEF) that can develop hemodynamic decompensation and multi-organ failure. Management of ES is challenging with limited available evidence coming from small retrospective series and a substantial lack of randomized-controlled trials. In general, a multidisciplinary approach including medical therapies such as anti-arrhythmic drugs, sedation, as well as interventional approaches like catheter ablation, may be required. Accurate patient risk stratification at admission for ES is pivotal and should take into account hemodynamic tolerability of VAs as well as comorbidities like low LVEF, advanced NYHA class and chronic pulmonary disease. In high risk patients, prophylactic mechanical circulatory support with left ventricular assistance devices or extracorporeal membrane oxygenation should be considered as bridge to ablation and recovery. In the present manuscript we review the available strategies for management of ES and the evidence supporting them. | Daniele Muser Pasquale Santangeli Jackson J Liang | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 4 | Chronic kidney disease and prevalent atrial fibrillation: The Chronic Renal Insufficiency Cohort (CRIC)显示文摘 | Elsayed Z. Soliman Ronald J. Prineas Alan S. Go Dawei Xie James P. Lash Mahboob Rahman Akinlolu Ojo Val L. Teal Nancy G. Jensvold Nancy L. Robinson Daniel L. Dries Lydia Bazzano Emile R. Mohler Jackson T. Wright Harold I. Feldman | 2010 | American Heart Journal2010，，6： | 2 |
| 5 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 6 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 7 | Fractional exhaled nitric oxide measurements are most closely associated with al-lergic sensitization in school-age children 显示文摘 | Daniel J Jackson MD Christine M | 2009 | J Allergy Clin Imrnunol2009，124，： | 1 |
| 8 | The salting-out effect and phase separation in aqueous solutions of electrolytes and poly(ethylene glycol)显示文摘 | Michael J. Hey Daniel P. Jackson Hong Yan | 2005 | Polymer2005，，8： | 1 |
| 9 | Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma显示文摘 | Elena Goleva Daniel A. Searing Leisa P. Jackson Brittany N. Richers Donald Y.M. Leung | 2012 | The Journal of Allergy and Clinical Immunology2012，，5： | 1 |
| 10 | Gastrointestinal Polyposis in Childhood: Clinicopathologic and Genetic Features显示文摘 | Amy Lowichik W. Daniel Jackson Cheryl M. Coffin | | Pediatric and Developmental Pathology0，，： | 1 |
| 11 | Isolation of Pseudomonas solanacearum-specfic DNA probe by subtraction hybridization and construction of species-specific oligonucleotide primers for sensitive detection by the polymerase chain reaction显示文摘 | Seal S E Jackson L A Daniels M J | 1992 | Appl Environ Microbiol1992，58，： | 1 |
| 12 | Emerging Issues in Pediatric Asthma: Gaps in EPR-3 Guidelines for Infants and Children显示文摘 | Daniel J. Jackson | 2014 | Current Allergy and Asthma Reports2014，，12： | 1 |
| 13 | Oxidative Stress Measured by Urine F2-Isoprostane Level is Associated With Prostate Cancer显示文摘 | Daniel A. Barocas Saundra Motley Michael S. Cookson Sam S. Chang David F. Penson Qi Dai Ginger Milne L. Jackson Roberts Jason Morrow Raoul S. Concepcion Joseph A. Smith Jay H. Fowke | 2011 | The Journal of Urology2011，，6： | 1 |
| 14 | Alloy:A lightweight object modelling notation显示文摘 | Daniel Jackson | 2002 | ACM Transactions on Software Engineering and Methodology(TOSEM)2002，11，2： | 1 |
| 15 | Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children显示文摘 | Daniel J Jackson MD Christine M | 2009 | J Allergy Clin Immunol2009，124，5： | 1 |
| 16 | Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘 | Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella | 2003 | Hypertension: Journal of The American Heart Association2003，，6： | 1 |
| 17 | Longitudinal Algorithms to Estimate Cardiorespiratory Fitness显示文摘 | Enrique G. Artero Andrew S. Jackson Xuemei Sui Duck-chul Lee Daniel P. O’Connor Carl J. Lavie Timothy S. Church Steven N. Blair | 2014 | Journal of the American College of Cardiology2014，，21： | 1 |
| 18 | A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling显示文摘 | Hiroki Iwai Minsoo Kim Yuko Yoshikawa Hiroshi Ashida Michinaga Ogawa Yukihiro Fujita Daniel Muller Teruo Kirikae Peter K. Jackson Shuji Kotani Chihiro Sasakawa | 2007 | Cell2007，，4： | 1 |
| 19 | Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘 | Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella | 2003 | Hypertension: Journal of The American Heart Association2003，，6： | 1 |
| 20 | Prognostic Value of Admission Fasting Glucose Levels in Patients With Acute Coronary Syndrome显示文摘 | Louis Kolman Yu-Chen Hu Daniel G. Montgomery Kelly Gordon Kim A. Eagle Elizabeth A. Jackson | 2009 | The American Journal of Cardiology2009，，4： | 1 |
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