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| 1 | ZBP1 mediates interferon-induced necroptosis显示文摘Interferons(IFNs)play an important role in immunomodulatory and antiviral functions.IFN-induced necroptosis has been reported in cells deficient in receptor-interacting protein kinase 1(RIPK1),Fas-associated protein with death domain(FADD),or caspase-8,but the mechanism is largely unknown.Here,we report that the DNA-dependent activator of IFN regulatory factors(ZBP1,also known as DAI)is required for both type Ⅰ(β)and type Ⅱ(γ)IFN-induced necroptosis.We show that L929 fibroblast cells became susceptible to IFN-induced necroptosis when RIPK1,FADD,or Caspase-8 was genetically deleted,confirming the antinecroptotic role of these proteins in IFN signaling.We found that the pronecroptotic signal from IFN stimulation depends on new protein synthesis and identified ZBP1,an IFN-stimulated gene(ISG)product,as the de novo synthesized protein that triggers necroptosis in IFN-stimulated cells.The N-terminal domain(ND)of ZBP1 is important for ZBP1–ZBP1 homointeraction,and its RHIM domain in the C-terminal region interacts with RIPK3 to initiate RIPK3-dependent necroptosis.The antinecroptotic function of RIPK1,FADD,and caspase-8 in IFN-treated cells is most likely executed by caspase-8-mediated cleavage of RIPK3,since the inhibitory effect on necroptosis was eliminated when the caspase-8 cleavage site in RIPK3 was mutated.ZBP1-mediated necroptosis in IFN-treated cells is likely physiologically relevant,as ZBP1 KO mice were significantly protected against acute systemic inflammatory response syndrome(SIRS)induced by TNF+IFN-γ. | Daowei Yang Yaoji Liang Shubo Zhao Yan Ding Qiuyu Zhuang Qilin Shi Tingting Ai Su-Qin Wu Jiahuai Han | 2020 | Cellular & Molecular Immunology2020，17，4： | 5 |
| 2 | Supported single Au(Ⅲ) ion catalysts for high performance in the reactions of 1,3-dicarbonyls with alcohols显示文摘 | Daowei Gao Xin Zhang Ying Yang Xiaoping Dai Hui Sun Yuchen Qin Aijun Duan | 2016 | Nano Research2016，9，4： | 3 |
| 3 | Perturbation of Auxin Homeostasis Caused by Mitochondrial FtSH4 Gene-Mediated Peroxidase Accumulation Regulates Arabidopsis Architecture显示文摘反应的氧种类和植物生长素在调整植物开发和形态基因的 changes.However 的网络起重要作用,位于在他们之间的相互作用下面的分子的机制糟糕被理解。孤立的这研究一妈(更腋的射击) 异种,它作为 mitochondrial AAA 朊酶 AtFtSH4 的等位基因被识别,并且在由调停调整植物开发描绘了 FtSH4 基因的功能在氢过氧化物之间的 peroxidase 依赖的相互影响(H 2 O 2) 和植物生长素动态平衡。侏儒症和增加的腋的分支的显型在妈观察了(作为 ftsh4-4 重命名) 从在 IAA 集中的减少的变异的结果。表明基因, includingIAA1, IAA2,和 IAA3 的几植物生长素的表达式层次,以及几植物生长素绑定和运输基因,在 ftsh4-4 植物显著地减少了。然而, H 2 O 2 和 peroxidases 层次,也举办 IAA oxidase 活动,显著地在 ftsh4-4 植物被提高。ftsh4-4 显型能被表示 iaaM 基因或由将 peroxidase 基因 PRX34 和 PRX33 击倒颠倒。两条途径能在 ftsh4-4 异种增加植物生长素层次。一起拿,提供的这些结果为在 mitochondrialATP 依赖的朊酶之间的相互作用指导分子、基因的证据, H 2 调整植物生长和 development.Key 词的 O 2, 和植物生长素动态平衡: | Shengchun Zhang Juelin Wu Dongke Yuan Daowei Zhang Zhigang Huang Langtao Xiao Chengwei Yang | 2014 | Molecular Plant2014，7，5： | 3 |
| 4 | Defect-density control of platinum-based nanoframes with high-index facets for enhanced electrochemical properties显示文摘Structure-engineered platinum-based nanoframes(NFs)at the atomic level can effectively improve the catalytic performance for fuel cells and other heterogeneous catalytic fields.We report herein,a microwave-assisted wet-chemical method for the preparation of platinum-copper-cobalt NFs with tunable defect density and architecture,which exhibit enhanced activity and durability towards the electro-oxidation reactions of methanol(MOR)and formic acid(FAOR).By altering the reduction/capping agents and thus the nucleation/growth kinetics,trimetallic platinum-copper-cobalt hexapod NFs with different density high-index facets are achieved.Especially,the rough hexapod nanoframes(rh-NFs)exhibit excellent specific activities towards MOR and FAOR,7.25 and 5.20 times higher than those of benchmark Pt/C,respectively,along with prolonged durability.The excellent activities of the rh-NFs are assigned to a synergistic effect,including high density of defects and high-index facets,suitable d-band center,and open-framework structure.This synergistic working mechanism opens up a new way for enhancing their electrocatalytic performances by increasing defect density and high-index facets in open-framework platinum-based NFs. | Shaohan Yang Shuna Li Lianghao Song Yipin Lv Zhongyao Duan Chunsheng Li Raphael Francesco Praeg Daowei Gao Guozhu Chen | 2019 | Nano Research2019，12，11： | 3 |
| 5 | Depositional System and Seismic Response of Subsurface Brines Reservoirs in Western Qaidam Basin,China显示文摘It is a major continuous depocenter in Dalangtan area,western Qaidam basin since Early Cenozoic,which is most important Neogene salt deposits center in Qaidam basin.The Miocene Saline lake was developed firstly | LI Qi LI Yujie YANG Qiangqiang ZHANG Daowei | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
| 6 | Dynamic Capture Method for Out-of-step Center of Power Grid Based on Measurement Information显示文摘This paper dynamically captures the out-of-step center for a bulk power system based on measurement information.First,the position characteristics of the out-of-step center are discussed from the perspective of triangular geometry under different potential and uniform impedance distributions based on a two-machine system.The correlation between the out-of-step center and the oscillation center is analyzed.Second,combined with analytical geometry,it is inferred that the distribution characteristics of the out-of-step center voltage vector ends are a circle or a straight line,and the position of the out-of-step center corresponds to the intersection between the voltage drop of the line and the distribution characteristics;then,the accurate location of the out-of-step center and the determination of the appearance moment is realized.Finally,a dynamic equivalence method for a power grid is proposed based on the electrical parameters of the transmission line,and an alternative iterative correction of equivalent parameters is carried out by trajectory sensitivity,which provides a new way for capturing the out-ofstep center dynamically in a multimachine system.The proposed method is validated using a three-machine system,the IEEE-39 system and the Northwest China Power Grid,and shows potential for online applications. | Zonghan Li Dongxia Zhang Daowei Liu Shaobo Yang Gaoshang Zhao | 2021 | CSEE Journal of Power and Energy Systems2021，7，6： | 0 |
| 7 | Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis显示文摘Introduction The dissemination of cancer cells to organs initiates the formation of an aggressive cancer phenotype and is a predominant cause of cancer-associated death.For most epithelial cancers,lymphatic system metastasis has been characterized as the most common and earliest metastatic pathway,and the detection of metastasis in lymph nodes(LNs)often predicts poor survival among patients'.Although increasing attention is being paid to the clinical importance of LN metastasis,the underlying mechanisms have remained unclear in the past decade.Accumulating evidence suggests that the occurrence of LN metastasis is not stochastic but is a programming biological event regulated by the bidirectional crosstalk between metastasis-initiating cancer cells and the tumor microenvironment(TME)2.However,the regulators and patterns of cancer-TME communication in LN metastasis remain to be furtherexplored. | Changhao Chen Yuming Luo Hanhao Zheng Dingwen Zhang Yao Kong Jiabin Yang Mingjie An Yan Lin Daowei Lin Rufu Chen | 2023 | Cancer Biology & Medicine2023，20，3： | 0 |
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