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| 1 | Conceptual study of lunar-based SAR for global change monitoring显示文摘As an active microwave remote sensing imaging sensor, Synthetic Aperture Radar(SAR) plays an important role in earth observation. Here we establish a SAR system based on the platform of the moon. This will aid large-scale, constant, and long-term dynamic Earth observations to better meet the needs of global change research and to complement the space borne and airborne earth observations. Lunar-based SAR systems have the characteristics of high resolution and wide swath width. The swath width could be thousands of kilometers in the stripe mode and it could cover 40% of earth's surface with 10 meters or even higher spatial resolution in the scanning mode. Using the simplified observation model, here we quantitatively analyze the spatial resolution and coverage area of lunar-based SAR and simulate the observation on the Qinghai-Tibet plateau and the Amazon plain. The results show that this system could provide near 100% daily coverage of the Qinghai-Tibet plateau, whereas 40% to 70% daily coverage of the Amazon plain. Lunar-based SAR could provide large-scale, long-term and stable time series data in order to support future research of global change. | GUO HuaDong DING YiXing LIU Guang ZHANG DaoWei FU WenXue ZHANG Lu | 2014 | Science China Earth Sciences2014，57，8： | 8 |
| 2 | Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1. | Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun | 2020 | International Journal of Oral Science2020，12，4： | 7 |
| 3 | Influence of chestnut tannins on welfare,carcass characteristics,meat quality,and lipid oxidation in rabbits under high ambient temperatu re显示文摘 | Huawei Liu Daowei Zhou Jianming Tong Venkata Vaddella | | 0，，： | 1 |
| 4 | Clinical significance of E-cadherin, β-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma显示文摘 | Hua Zhang Jun Liu Dongsheng Yue Liuwei Gao Daowei Wang Hongdian Zhang Changli Wang | 2013 | Journal of Clinical Pathology2013，，11： | 1 |
| 5 | Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration显示文摘Nanomaterial-based drug sustainable release systems have been tentatively applied to bone regeneration.They,however,still face disadvantages of high toxicity,low biocompatibility,and low drug-load capacity.In view of the low toxicity and high biocompatibility of polymer nanomaterials and the excellent load capacity of hollow nanomaterials with high specific surface area,we evaluated the hollow polydopamine nanoparticles(HPDA NPs),in order to find an optimal system to effectively deliver the osteogenic drugs to improve treatment of bone defect.Data demonstrated that the HPDA NPs synthesized herein could efficiently load four types of osteogenic drugs and the drugs can effectively release from the HPDA NPs for a relatively longer time in vitro and in vivo with low toxicity and high biocompatibility.Results of qRT-PCR,ALP,and alizarin red S staining showed that drugs released from the HPDA NPs could promote osteogenic differentiation and proliferation of rat bone marrow mesenchymal stem cells(rBMSCs)in vitro.Image data from micro-CT and H&E staining showed that all four osteogenic drugs released from the HPDA NPs effectively promoted bone regeneration in the defect of tooth extraction fossa in vivo,especially tacrolimus.These results suggest that the HPDA NPs,the biodegradable hollow polymer nanoparticles with high drug load rate and sustainable release ability,have good prospect to treat the bone defect in future clinical practice. | Lu Wang Shuwei Liu Chunxia Ren Siyuan Xiang Daowei Li Xinqing Hao Shilei Ni Yixin Chen Kai Zhang Hongchen Sun | 2021 | International Journal of Oral Science2021，13，3： | 0 |
| 6 | Dynamic Capture Method for Out-of-step Center of Power Grid Based on Measurement Information显示文摘This paper dynamically captures the out-of-step center for a bulk power system based on measurement information.First,the position characteristics of the out-of-step center are discussed from the perspective of triangular geometry under different potential and uniform impedance distributions based on a two-machine system.The correlation between the out-of-step center and the oscillation center is analyzed.Second,combined with analytical geometry,it is inferred that the distribution characteristics of the out-of-step center voltage vector ends are a circle or a straight line,and the position of the out-of-step center corresponds to the intersection between the voltage drop of the line and the distribution characteristics;then,the accurate location of the out-of-step center and the determination of the appearance moment is realized.Finally,a dynamic equivalence method for a power grid is proposed based on the electrical parameters of the transmission line,and an alternative iterative correction of equivalent parameters is carried out by trajectory sensitivity,which provides a new way for capturing the out-ofstep center dynamically in a multimachine system.The proposed method is validated using a three-machine system,the IEEE-39 system and the Northwest China Power Grid,and shows potential for online applications. | Zonghan Li Dongxia Zhang Daowei Liu Shaobo Yang Gaoshang Zhao | 2021 | CSEE Journal of Power and Energy Systems2021，7，6： | 0 |
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