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| 1 | Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome:A randomized,double-blind study显示文摘AIM:To assess the effects and safety of Lactobacillus casei rhamnosus LCR35 complete freeze-dried culture(LCR35) in patients suffering from irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in 50 patients complaining of IBS symptoms complying with RomeⅢcriteria.Patients were allocated to receive either LCR35(n = 25) at a minimum daily dose of 6 × 108 colony forming units or placebo(n = 25) for 4 wk.At inclusion,after treatment and 2 wk later,patients completed the IBS severity scale.Change from baseline in the IBS severity score at the end of treatment was the primary efficacy criterion.Changes were compared between groups in the whole population and in IBS subtypes(IBS with predominance of constipation,IBS with predominance of diarrhoea,mixed IBS,unsubtyped IBS).The presence of lactobacillus casei rhamnosus in stools was investigated at inclusion and at the end of treatment.The gastrointestinal quality of life questionnaire and the hospital anxiety and depression(HAD) scale were also completed.RESULTS:Both groups were balanced for baseline characteristics.In 85% of patients,stool analyses showed that lactobacillus casei rhamnosus able to survive in the digestive tract.In the whole population,improvements in the IBS severity score did not differ significantly between treatments with a 25% decrease after 4-wk treatment,and a 15% decrease from baseline 2 wk later in both groups.In IBS subgroups,statistical analysis could not be performed due to small sample size,but a clinical response in favour of LCR35 was observed in IBS patients with predominance of diarrhoea:no change in the symptom severity score was seen with the placebo after 4 wk treatment,whereas a clinically relevant decrease occurred with LCR35(-37% vs-3%).Furthermore,in spite of an increase in symptom intensity,the IBS severity score was maintained below the baseline value 2 wk later with LCR35(-19% from baseline),whilst a slight 5% increase from baseline was observed with placebo.In the IBS subgroup with predominance of diarrhoea only,a clinically relevant decrease in abdominal pain severity score(-36%)was observed with LCR35,whereas no change occurred with placebo.In mixed IBS patients,the 20% and 30% decreases in the IBS severity score observed after treatment with LCR35 and placebo,respectively,were maintained 2 wk later in both groups.A clinical response slightly in favour of placebo was observed at the end of the treatment period in IBS patients with predominance of constipation(-41% vs-20%) and unsubtyped IBS patients(-47% vs-17%),with the same value maintained 2 wk later.In both groups,no clinically relevant changes were observed either for the gastrointestinal quality of life index or HAD score.Thus,these results suggest that sub-grouping of IBS patients may be important for optimizing treatment responses by the physician.CONCLUSION:This pilot study suggests that LCR35 could have some efficacy in IBS patients complaining of diarrhoea.These preliminary results need to be conf irmed in larger studies. | Michel Dapoigny Thierry Piche Philippe Ducrotte Bernard Lunaud Jean-Michel Cardot Annick Bernalier-Donadille | 2012 | World Journal of Gastroenterology2012，18，17： | 10 |
| 2 | Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome显示文摘 | J. Matricon M. Meleine A. Gelot T. Piche M. Dapoigny E. Muller D. Ardid | 2012 | Aliment Pharmacol Ther (pt)2012，，11： | 6 |
| 3 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 4 | Large-balloon dilation of the sphincter of Oddi after sphincterotomy or infundibulotomy to extract large calculi or multiple common bile duct stones without using mechanical lithotripsy显示文摘 | Laurent Poincloux Olivier Rouquette Jocelyn Privat Daniel Gorce Armand Abergel Michel Dapoigny Gilles Bommelaer | 2013 | Scandinavian Journal of Gastroenterology2013，，2： | 2 |
| 5 | Enhanced weathering input from South Asia to the Indian Ocean since the late Eocene显示文摘nhanced silicate weathering induced by the uplift of the Himalayan-Tibetan Plateau(HTP)has been considered as the major cause of pCO_(2) decline and Cenozoic cooling.However,this hypothesis remains to be validated,largely due to the lack of a reliable reconstruction of the HTP weathering flux.Here,we present a 37-million-year record of the difference in the seawater radiogenic neodymium isotopic composition(△ε_(Nd))of Ocean Drilling Program(ODP)sites and Fe-Mn crusts between the northern and central Indian Ocean,which indicates the contribution of regional weathering input from the South Asian continent to the Indian Ocean.The results show a long-term increase in △ε_(Nd) and thus provide the first critical evidence of enhanced South Asian weathering input since the late Eocene.The evolution coincided well with major pulses of surface uplift in the HTP and global climatic transitions.Our foraminiferal eNd record suggests that tectonic uplift and silicate weathering in South Asia,especially in the Himalayas,might have played a significant role in the late Cenozoic cooling. | Zehua Song Shiming Wan Christophe Colin Christian France-Lanord Zhaojie Yu Arnaud Dapoigny Hualong Jin Mengjun Li Jin Zhang Debo Zhao Xuefa Shi Anchun Li | 2023 | Science Bulletin2023，，3： | 2 |
| 6 | Motility in iIrritable bowel syndrome显示文摘 | Muller-Lissner S Coremans G Dapoigny M | 1997 | Digestion1997，58，： | 1 |
| 7 | The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota显示文摘 | L. Crouzet E. Gaultier C. Del’Homme C. Cartier E. Delmas M. Dapoigny J. Fioramonti A. Bernalier‐Donadille | 2013 | Neurogastroenterol Motil2013，，4： | 1 |
| 8 | Irritable bowel syndrome in France: quality of life, medical management, and costs: the Encoli study显示文摘 | Catherine Brun-Strang Michel Dapoigny Antoine Lafuma Jean Pierre Wainsten Francis Fagnani | 2007 | European Journal of Gastroenterology & Hepatology2007，，12： | 1 |
| 9 | He mass spec- trometry for very low - level measurement of organic tritium in envi- romnental samples显示文摘 | Jean -Baptiste P Fourr6 E Dapoigny A | 2010 | J Environ Radioact2010，101，2： | 1 |
| 10 | Role of alimentation in irritable bowel syndrome 显示文摘 | Dapoigny M Stockbrugger RW Azpiroz F | 2003 | Digestion2003，67，4： | 1 |
| 11 | Nongastroin-testinal disorders in the irritable bowel syndrome显示文摘 | Azpiroz F Dapoigny M Pace F | 2000 | Digestion2000，62，1： | 1 |
| 12 | Role of alimentation in irritable bowel syndrome显示文摘 | Dapoigny M Stockbrtügger RW Azpiroz F | 2003 | Digestion2003，67，4： | 1 |
| 13 | Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome显示文摘 | Chassard C Dapoigny M Scott KP | | 0，，： | 1 |
| 14 | Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome 显示文摘 | Chassard C Dapoigny M Scott KP etal | 2012 | Aliment Pharmacol Ther2012，35，7： | 1 |
| 15 | Relationship between severity of symptoms and quality of life in 858 patients with irritable bowel syndrome显示文摘 | Benoit Coffin Michel Dapoigny Denis Cloarec Denis Comet Fran?ois Dyard | 2004 | Gastroenterologie Clinique et Biologique2004，，1： | 1 |
| 16 | Nongastrointestinal disorders in the irritable bowel syndrome显示文摘 | Azpiroz F dapoigny M Pace F | 2000 | Digestion2000，，1： | 1 |
| 17 | Chronic intestinal pseudo-obstruction in systemic lupus erythematosus显示文摘 | Cacoub P Dapoigny M Kahan A | 1998 | Gut1998，43，1： | 1 |
| 18 | Nongas- trointestinal disorders in the irritable bowel syndrome 显示文摘 | Azpiroz F Dapoigny M Pace F | 2000 | Digestion2000，62，1： | 1 |
| 19 | Large-balloon dilation of the sphincter of Oddi after sphincterotomy or infundibulotomy to extract large calculi or multiple common bile duct stones without using mechanical lithotripsy显示文摘 | Laurent Poincloux Olivier Rouquette Jocelyn Privat Daniel Gorce Armand Abergel Michel Dapoigny Gilles Bommelaer | 2013 | Scandinavian Journal of Gastroenterology2013，，2： | 1 |
| 20 | The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota显示文摘 | L. Crouzet E. Gaultier C. Del’Homme C. Cartier E. Delmas M. Dapoigny J. Fioramonti A. Bernalier‐Donadille | 2013 | Neurogastroenterol Motil2013，，4： | 1 |
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