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| 1 | Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis显示文摘 | Daquan Meng Mingli Yuan Xiaojuan Li Lijun Chen Jie Yang Xin Zhao Wanli Ma Jianbao Xin | 2013 | Lung Cancer2013，，1： | 1 |
| 2 | Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis显示文摘 | Daquan Meng Mingli Yuan Xiaojuan Li Lijun Chen Jie Yang Xin Zhao Wanli Ma Jianbao Xin | 2013 | Lung Cancer2013，，1： | 1 |
| 3 | Effects of abiotic components induced by biochar on microbial communities显示文摘 | Daquan Sun Jun Meng Wenfu Chen | 2013 | Acta Agriculturae Scandinavica Section B - Soil & Plant Science2013，，7： | 1 |
| 4 | Intratumoural microbiota:a new frontier in cancer development and therapy显示文摘Human microorganisms,including bacteria,fungi,and viruses,play key roles in several physiological and pathological processes.Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,which have been confirmed to be closely related to oncogenesis.The concept of intratumoural microbiota was subsequently proposed.Microbiota could colonise tumour tissues through mucosal destruction,adjacent tissue migration,and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment.Mechanistic studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations,affecting epigenetic modifications,promoting inflammation response,avoiding immune destruction,regulating metabolism,and activating invasion and metastasis.Since more comprehensive and profound insights about intratumoral microbiota are continuously emerging,new methods for the early diagnosis and prognostic assessment of cancer patients have been under examination.In addition,interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy,especially immunotherapy,although there are some inevitable challenges.Here,we aim to provide an extensive review of the concept,development history,potential sources,heterogeneity,and carcinogenic mechanisms of intratumoural microorganisms,explore the potential role of microorganisms in tumour prognosis,and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field. | Yaqi Cao Hui Xia Xueyun Tan Chunwei Shi Yanling Ma Daquan Meng Mengmeng Zhou Zhilei Lv Sufei Wang Yang Jin | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 5 | CD47KO/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy显示文摘Tumor vaccines trigger tumor-specific immune responses to prevent or treat tumors by activating the hosts’immune systems,and therefore,these vaccines have potential clinical applications.However,the low immunogenicity of the tumor antigen itself and the low efficiency of the vaccine delivery system hinder the efficacy of tumor vaccines that cannot produce high-efficiency and long-lasting antitumor immune effects.Here,we constructed a nanovaccine by integrating CD47KO/CRT dual-bioengineered B16F10 cancer cell membranes and the unmethylated cytosine-phosphate-guanine(CpG)adjuvant.Hyperbranched PEI25k was used to load unmethylated cytosine-phosphate-guanine(CpG)through electrostatic adsorption to prepare PEI25k/CpG nanoparticles(PEI25k/CpG-NPs).CD47KO/CRT dual-bioengineered cells were obtained by CRISPR-Cas9 gene editing technology,followed by the cell surface translocation of calreticulin(CRT)to induce immunogenic cell death(ICD)in vitro.Finally,the extracted cell membranes were coextruded with PEI25k/CpG-NPs to construct the CD47KO/CRT dual-bioengineered cancer cell membrane-coated nanoparticles(DBE@CCNPs).DBE@CCNPs could promote endocytosis of antigens and adjuvants in murine bone marrow derived dendritic cells(BMDCs)and induce their maturation and antigen cross-presentation.To avoid immune checkpoint molecule-induced T cell dysfunction,the immune checkpoint inhibitor,the anti-PD-L1 antibody,was introduced to boost tumor immunotherapy through a combination with the DBE@CCNPs nanovaccine.This combination therapy strategy can significantly alleviate tumor growth and may open up a potential strategy for clinical tumor immunotherapy. | Shengyang Liu Jiayan Wu Yuanji Feng Xiaoya Guo Tong Li Meng Meng Jie Chen Daquan Chen Huayu Tian | 2023 | Bioactive Materials2023，，4： | 0 |
| 6 | Mental health, health-related quality of life, and lung function after hospital discharge in healthcare workers with severe COVID-19: a cohort study from China显示文摘Coronavirus disease 2019(COVID-19)is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.It is highly contagious and can cause death in severe cases.As reported by the World Health Organization(WHO),as of 6:36 pm Central European Summer Time(CEST),12 August 2022,there had been 585950285 confirmed cases of COVID-19,including 6425422 deaths(WHO,2022).According to previous studies,healthcare workers(HCWs)have a higher risk of developing COVID-19 compared with the general community,and the severity of COVID-19 is closely related to the health-related effects after discharge(Huang et al.,2021). | Lijuan XIONG Qian LI Xiongjing CAO Huangguo XIONG Daquan MENG Mei ZHOU Yanzhao ZHANG Xinliang HE Yupeng ZHANG Liang TANG Yang JIN Jiahong XIA Yu HU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 0 |
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