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| 1 | Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats显示文摘The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel disease in rats.Naringin(20,40 and 80 mg/kg) was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4%(v/v) acetic acid solution.The degree of colonic mucosal damage was analyzed by examining mucosal damage,ulcer area,ulcer index and stool consistency.Intrarectal administration of 4%acetic acid resulted in significant modulation of serum alkaline phosphatase,lactate dehydrogenase,superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA) and myeloperoxidase(MPO) content along with colonic nitric oxide(NO),xanthine oxidase(XO) level and protein carbonyl content in the colonic tissue as well as in blood.Naringin(40 and 80 mg/kg) exerted a dose dependent(P < 0.05) ameliorative effect,as it significantly increased hematological parameter as well as colonic SOD and GSH.There was a significant(P < 0.05)and dose dependant inhibition of macroscopical score,ulcer area along with colonic MDA,MPO activity by the7 days of pretreatment of naringin(40 and 80 mg/kg).Biochemical studies revealed a significant(P < 0.05) dose dependant inhibition in serum alkaline phosphatase(ALP) and lactate dehydrogenase(LDH) levels by pretreatment of naringin.Increased levels of colonic NO,XO,protein carbonyl content and DNA damage were also significantly decreased by naringin pretreatment.The findings of the present investigation propose that naringin has an anti-inflammatory,anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA,MPO,NO and XO,thus reducing DNA damage. | Venkatashivam Shiva Kumar Anuchandra Ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar | 2014 | The Journal of Biomedical Research2014，28，2： | 8 |
| 2 | 用椰壳制活性炭吸附去除三价铋离子(英文)显示文摘In present study,we report the preparation of coconut shell activated carbon as adsorbent and its appli-cation for Bi(Ⅲ) removal from aqueous solutions.The developed adsorbent was characterized with scanning elec-tron microscope(SEM),Fourier Transform Infrared(FTIR),C,H,N,S analyzer,and BET surface area analyzer.The parameters examined include agitation time,initial concentration of Bi(Ⅲ),adsorbent dose and temperature.The maximum adsorption of Bi(Ⅲ)(98.72%) was observed at 250 mg·L-1 of Bi(Ⅲ) and adsorbent dose of 0.7 g when agitation was at 160 r·min-1 for 240 min at(299±2) K.The thermodynamic parameters such as Gibb's free energy(△Gθ),enthalpy(△Hθ) and entropy(△Sθ) were evaluated.For the isotherm models applied to adsorption study,the Langmuir isotherm model fits better than the Freundlich isotherm.The maximum adsorption capacity from the Langmuir isotherm was 54.35 mg?g?1 of Bi(Ⅲ).The kinetic study of the adsorption shows that the pseudo second order model is more appropriate than the pseudo first order model.The result shows that,coconut shell ac-tivated carbon is an effective adsorbent to remove Bi(Ⅲ) from aqueous solutions with good adsorption capacity. | SARTAPE Ashish MANDHARE Aniruddha SALVI Prathmesh PAWAR Dattatraya RAUT Prakash ANUSE Mansing KOLEKAR Sanjay | 2012 | Chinese Journal of Chemical Engineering2012，20，4： | 3 |
| 3 | A novel preoperative inflammatory marker prognostic score in patients with localized and metastatic renal cell carcinoma显示文摘Objective:Several inflammatory markers have been studied as potential biomarkers in renal cell carcinoma(RCC),however few reports have analyzed their prognostic value in aggregate and in non-clear cell histologies.We hypothesize that a combination of specific inflammatory markers into an RCC Inflammatory Score(RISK)could serve as a rigorous prognostic indicator of overall survival(OS)in patients with clear cell and non-clear cell RCC.Methods:Combination of preoperative C-reactive protein(CRP),albumin,erythrocyte sedimentation rate(ESR),corrected calcium,and aspartate transaminase to alanine transaminase(AST/ALT)ratio was used to develop RISK.RISK was developed using grid-search methodology,receiver-operating-characteristic(ROC)analysis,and sensitivity-specificity trade-off analysis.Prognostic value of RISK was analyzed using the KaplaneMeier method and Cox proportional regression models.Predictive accuracy was compared with RISK to Size,Size,Grade,and Necrosis(SSIGN)score,University of California-LOS Angeles(UCLA)Integrated Staging System(UISS),and Leibovich Prognosis Score(LPS). | Rishi R.Sekar Dattatraya Patil Yoram Baum Jeffrey Pearl Anna Bausum Mehmet A.Bilen Omer Kucuk Wayne B.Harris Bradley C.Carthon Mehrdad Alemozaffar Christopher P.Filson John G.Pattaras Peter T.Nieh Kenneth Ogan Viraj A.Master | 2017 | Asian Journal of Urology2017，4，4： | 2 |
| 4 | Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma显示文摘 | Navjot Kaur Sivarajan Chettiar Sachin Rathod Phalguni Rath Dattatraya Muzumdar M.L. Shaikh Anjali Shiras | 2013 | Molecular and Cellular Neuroscience2013，，： | 2 |
| 5 | Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways显示文摘 | Sachin S. Rathod Sandhya B. Rani Mohsina Khan Dattatraya Muzumdar Anjali Shiras | 2014 | FEBS Open Bio2014，，： | 1 |
| 6 | Atlantoaxial Fixation Using Plate and Screw Method: A Report of 160 Treated Patients显示文摘 | Atul Goel Ketan I. Desai Dattatraya P. Muzumdar | 2002 | Neurosurgery2002，，6： | 1 |
| 7 | Treatment of posterior fossa tumors in children 显示文摘 | Muzumdar Dattatraya Ventureyra Enrique CG | 2010 | Expert review of neurotherapeutics2010，10，4： | 1 |
| 8 | Artificial Neural Network (ANN) Based Pavement Deterioration Models for Low Volume Roads in India 显示文摘 | Dattatraya T T | 2012 | International Journal of Pavement Research and Technology2012，5，2： | 1 |
| 9 | Reactive robots and amnesics: a comparative study in memoryless behavior 显示文摘 | DATTATRAYA A | 1999 | IEEE Trans on Systems Man and Cybernetics Part C:Applications and Reviews1999，29，2： | 1 |
| 10 | Wavelet Based ImageFusion Using Pixel Based Maximum Selection Rule显示文摘 | Godse Deepa Li A Bormane Dattatraya S | 2011 | International Jour-nal of Engineering Science&Technology2011，37，： | 1 |
| 11 | AlON: A brief history of its emergence and evolution显示文摘 | James W. McCauley Parimal Patel Mingwei Chen Gary Gilde Elmar Strassburger Bhasker Paliwal K.T. Ramesh Dattatraya P. Dandekar | 2008 | Journal of the European Ceramic Society2008，，2： | 1 |
| 12 | Basak,et ah Variability in Foliar Essential Oils among Different Morphotypes of Lantana Spe- cies Complexes,and Its Taxonomic and Ecological Significance 显示文摘 | Amit Lovel Dattatraya Naik Sandip K | 2010 | Chemistry & Biodiversity2010，6，12： | 1 |
| 13 | Shock response of heavy tungsten alloy显示文摘 | Dattatraya P D William J W | 1999 | International Journal of Plasticity1999，15，12： | 1 |
| 14 | A prospective study of patient reported urinary incontinence among American, Norwegian and Spanish men 1 year after prostatectomy显示文摘Objective:To compare pre-and post-radical prostatectomy(RP)responses in the urinary incontinence domain of Expanded Prostate Cancer Index Composite-26(EPIC-26)in cohorts from the USA,Norway and Spain.Methods:A prospective study of pre-and 1-year post-treatment responses in American(nZ537),Norwegian(nZ520)and Spanish(nZ111)patients,establishing the prevalence of urinary incontinence defined according to published dichotomization.Thereafter we focused on the response alternatives“occasional dribbling”,pad use and problem experience.A multivariate logistic regression analysis(significance level≤0.01)considered risk factors for“not retaining total control”. | Anne Holck Storas Martin GSanda Olatz Garin Peter Chang Dattatraya Patil Catrina Crociani Jose Francisco Suarez Milada Cvancarova Jon Havard Loge Sophie DFossa | 2020 | Asian Journal of Urology2020，7，2： | 1 |
| 15 | Atlantoaxial Fixation Using Plate and Screw Method: A Report of 160 Treated Patients显示文摘 | Atul Goel Ketan I. Desai Dattatraya P. Muzumdar | 2002 | Neurosurgery2002，，6： | 1 |
| 16 | Surgical management of giant pituitary adenomas显示文摘 | Atul Goel Dattatraya Muzumdar | 2004 | Inter Congress Series2004，1259，： | 1 |
| 17 | Comparative quantitative analysis of fruit oil from Hippophae rhamnoides(seabuckthorn) by qNMR, FTIR and GC–MS显示文摘Objective: To develop a qNMR method for quantitative analysis of triacylglycerols in fruit oil of Hippophae rhamnoides(seabuckthorn, SBT) and analyze commercial samples of SBT oils using GC–MS and FTIR.Methods: SBT fruit oil(IPHRFH) was extracted with hexane and the triglyceride(TAG) was isolated by vacuum liquid chromatography. Six different branded SBT oils purchased from e-commerce suppliers(Amazon) and in-house prepared SBT oil was analyzed by qNMR and fatty acyl composition of TAGs determined by using NMR. In-house oil was also analysed by GC–MS and FTIR spectroscopy.Results: The qNMR results showed that the oil contained 80.3% of triacylglycerol(TAG). The SBT oil TAGs comprised of linolenate 6.6%, palmitoleate/oleate 65.4%, and total saturated fatty acyl chain including palmitate 28% as determined by qNMR. GC–MS analysis revealed that the major acyl functionalities present in the TAG were palmitoleic acid 36.5%, oleic acid 12.9%, palmitic acid 21.2%, and linoleic acid 18%. Of the six commercial samples analyzed, samples from only one supplier(SW) were fruit oil;All others were the seed oils or mix of fruit oil and seed oil. The labels for samples except for the SW did not indicate whether it was fruit oil or seed oil.Conclusion: The results suggest that SBT oil should be analyzed by combination of GC–MS, FTIR and qNMR for factual content of free fatty acid or TAGs, which are chemically different in nature and affect the quality of oil. GC–MS showed the content of omega free fatty acids after hydrolysis, while qNMR and FTIR showed the content of TAGs. The major acyl functionalities found in SBT fruit oil TAGs are palmitoleate/palmitate/oleate, while linoleate and linonelate make up a minor fraction. Furthermore,analysis of commercial samples showed discrepancies between label claims and actual content. | Dattatraya Dinkar Gore Furkan Ahmad Kulbhushan Tikoo Arvind Kumar Bansal Dinesh Kumar Inder Pal Singh | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 18 | Elevated preoperative neutrophil-tolymphocyte ratio may be associated with decreased overall survival in patients with metastatic clear cell renal cell carcinoma undergoing cytoreductive nephrectomy显示文摘Objective:Inflammatory serum markers have proven to be a powerful predictive tool of patient prognosis in cancer treatment for a wide variety of solid organ malignancies,predominantly in the context of localized disease.In this study we evaluated the preoperative neutrophil-to-lymphocyte ratio(NLR)as a predictive tool in patients with metastatic clear cell renal cell carcinoma(RCC).Methods:Sixty-four patients with metastatic clear cell RCC undergoing nephrectomy were selected.Only patients with preoperative NLR were included for survival analysis.Patients were categorized into high and low NLR score determined by plotting the NLR ROC curve.Multivariable analysis was performed.Results:Median age was 60.8 years(38.2-81.2).Median follow-up time was 8.1 months(0.1-106.3).Fuhrman grade distribution was:2(3.1%)grade 1,6(9.4%)grade 2,24(37.5%)grade 3 and 32(50.0%)grade 4.Median NLR score was 3.5(1.4-31.0).NLR4 was associated with decreased overall survival compared toNLR<4(p=0.017).Multivariable survival analysis showed NLR4 as an independent predictor of survival(Hazard ratio(HR)2.41,95%CI 1.05-5.50,p=0.03).Conclusion:Elevated preoperative NLR is associatedwith poor prognosis in patients withmetastatic kidney cancer.Preoperative NLR is a useful tool,which can predict prognosis,stratify patients for postoperative surveillance,and help guide decisions for therapy. | Yoram S.Baum Dattatraya Patil Jonathan H.Huang Stephanie Spetka Mersiha Torlak Peter T.Nieh Mehrdad Alemozaffar Kenneth Ogan Viraj A.Master | 2016 | Asian Journal of Urology2016，3，1： | 0 |
| 19 | Hypogonadism is independently associated with varicocele repair-in a contemporary cohort of men in the USA显示文摘We aimed to identify demographic and clinical predictors of varicocele repair in a contemporary cohort of men in the USA.We queried the 2009-2015 MarketScan Database using relevant ICD9,ICD10,and CPT codes to identify all 18-45 year olds with varicoceles.Differences in age,area of residence,clinical characteristics,and medical management between men who did and did not undergo varicocelectomy (open,laparoscopic,or microsurgical)during the study period were compared using unpaired t-tests and Chi-squared tests for continuous and categorical variables,respectively.Multivariable logistic regression analysis was used to evaluate age,semen analyses,and serum hormone assessment as predictors of varicocele repair.SAS version 9.4 was used for all statistical analyses.Significance was set at P <0.05.Approximately 40%of men with varicoceles underwent repair, primarily through an open approach.Men who underwent repair were more likely to have a diagnosis of male infertility (15.5%vs 7.9%,P <0.001)and male hypogonadism (3.4% vs 0.9%)and were more likely to complete semen analyses (36.1%vs 12.2%, P <0.001)and serum testosterone evaluation (42.5%vs 18.8%,P <0.001).In multivariable regression models,the strongest predictors of varicocele repair were semen analysis (OR =2.78,95%Ch 2.56-3.02),age 18-25 years (OR =2.66,95%CI. 2.36-2.98),and serum testosterone evaluation (OR =1.67,95%CI.1.51-1.86).Although male infertility remains the most important indication for varicocele repair,male hypogonadism is emerging as an independent predictor of varicocelectomy,which may represent a change in the clinical management of varicoceles in the USA. | Cailey Guercio Dattatraya Patil Akanksha Mehta | 2019 | Asian Journal of Andrology2019，21，1： | 0 |
| 20 | Survival benefit with extended lymphadenectomy for advanced renal malignancy: A population-based analysis显示文摘Objective:We used population-based data to examine the possible benefit of extended lymphadenectomy for patients with renal malignancy in the setting of more advanced disease.Methods:The Surveillance,Epidemiology,and End Results(SEER)database was utilized to identify non-metastatic,T3-T4 renal cancer patients from 2004-2015 treated with removal of≥1 lymph node at the time of nephrectomy.Non-parametric bivariate statistics were used to assess associations between covariates of interest and extended lymphadenectomy(≥10 lymph nodes removed).Cancer-specific survival(CSS)and overall survival(OS)benefit was evaluated using Kaplane-Meier analysis.Results:Of the 4397 patients identified,816(18.6%)underwent extended lymphadenectomy.For patients with T3a disease,5-year CSS and OS benefit with extended lymphadenectomy did not reach statistical significance(CSS:hazard ratio[HR]0.98,95%confidence interval[CI]0.77-1.24;OS:HR 0.96,95%CI 0.77-1.20).Conversely,for those with T3b-T3c disease,extended lymphadenectomy led to statistically significant improvements in both 5-year CSS and OS compared to non-extended lymphadenectomy(CSS:HR 0.78,95%CI 0.61-0.99;OS:HR 0.72,95%CI 0.58-0.90).Finally,for those with T4 disease,use of extended lymphadenectomy had OS benefit after 5 years(OS:HR 0.51,HR 0.29-0.90,p = 0.02).Conclusion:Based on population-level data,extended lymphadenectomy was associated with improved survival in select patients with advanced renal malignancy treated with surgical nephrectomy.Understanding the basis of these real-world findings in the face of conflicting randomized trial results will be key,moving forward. | Dean Laganosky Christopher P.Filson Dattatraya Patil Viraj A.Master | 2020 | Asian Journal of Urology2020，7，1： | 0 |
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