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| 1 | A novel preoperative inflammatory marker prognostic score in patients with localized and metastatic renal cell carcinoma显示文摘Objective:Several inflammatory markers have been studied as potential biomarkers in renal cell carcinoma(RCC),however few reports have analyzed their prognostic value in aggregate and in non-clear cell histologies.We hypothesize that a combination of specific inflammatory markers into an RCC Inflammatory Score(RISK)could serve as a rigorous prognostic indicator of overall survival(OS)in patients with clear cell and non-clear cell RCC.Methods:Combination of preoperative C-reactive protein(CRP),albumin,erythrocyte sedimentation rate(ESR),corrected calcium,and aspartate transaminase to alanine transaminase(AST/ALT)ratio was used to develop RISK.RISK was developed using grid-search methodology,receiver-operating-characteristic(ROC)analysis,and sensitivity-specificity trade-off analysis.Prognostic value of RISK was analyzed using the KaplaneMeier method and Cox proportional regression models.Predictive accuracy was compared with RISK to Size,Size,Grade,and Necrosis(SSIGN)score,University of California-LOS Angeles(UCLA)Integrated Staging System(UISS),and Leibovich Prognosis Score(LPS). | Rishi R.Sekar Dattatraya Patil Yoram Baum Jeffrey Pearl Anna Bausum Mehmet A.Bilen Omer Kucuk Wayne B.Harris Bradley C.Carthon Mehrdad Alemozaffar Christopher P.Filson John G.Pattaras Peter T.Nieh Kenneth Ogan Viraj A.Master | 2017 | Asian Journal of Urology2017，4，4： | 2 |
| 2 | Pathophysiology and Management of Infectious Staghorn Calculi显示文摘 | Kelly A. Healy Kenneth Ogan | 2007 | Urologic Clinics of North America2007，，3： | 2 |
| 3 | Renal cell carcinoma in patients with end‐stage renal disease has favorable overall prognosis显示文摘 | Adam B. Shrewsberry Adeboye O. Osunkoya Kun Jiang Ruth Westby Daniel Canter John Pattaras Nicole Turgeon Viraj A. Master Kenneth Ogan | 2014 | Clin Transplant2014，，： | 1 |
| 4 | Too Frail for Surgery?: Initial Results of a Large Multidisciplinary Prospective Study Examining Pre-operative Variables Predictive of Poor Surgical Outcomes显示文摘 | Louis M. Revenig Daniel J. Canter Maxwell D. Taylor Caroline Tai John F. Sweeney Juan M. Sarmiento David A. Kooby Shishir K. Maithel Viraj A. Master Kenneth Ogan | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 5 | Effects of Obesity and Weight Loss in Patients With Nononcological Urological Disease显示文摘 | Vivek Natarajan Viraj Master Kenneth Ogan | 2009 | The Journal of Urology2009，，6： | 1 |
| 6 | Elevated preoperative neutrophil-tolymphocyte ratio may be associated with decreased overall survival in patients with metastatic clear cell renal cell carcinoma undergoing cytoreductive nephrectomy显示文摘Objective:Inflammatory serum markers have proven to be a powerful predictive tool of patient prognosis in cancer treatment for a wide variety of solid organ malignancies,predominantly in the context of localized disease.In this study we evaluated the preoperative neutrophil-to-lymphocyte ratio(NLR)as a predictive tool in patients with metastatic clear cell renal cell carcinoma(RCC).Methods:Sixty-four patients with metastatic clear cell RCC undergoing nephrectomy were selected.Only patients with preoperative NLR were included for survival analysis.Patients were categorized into high and low NLR score determined by plotting the NLR ROC curve.Multivariable analysis was performed.Results:Median age was 60.8 years(38.2-81.2).Median follow-up time was 8.1 months(0.1-106.3).Fuhrman grade distribution was:2(3.1%)grade 1,6(9.4%)grade 2,24(37.5%)grade 3 and 32(50.0%)grade 4.Median NLR score was 3.5(1.4-31.0).NLR4 was associated with decreased overall survival compared toNLR<4(p=0.017).Multivariable survival analysis showed NLR4 as an independent predictor of survival(Hazard ratio(HR)2.41,95%CI 1.05-5.50,p=0.03).Conclusion:Elevated preoperative NLR is associatedwith poor prognosis in patients withmetastatic kidney cancer.Preoperative NLR is a useful tool,which can predict prognosis,stratify patients for postoperative surveillance,and help guide decisions for therapy. | Yoram S.Baum Dattatraya Patil Jonathan H.Huang Stephanie Spetka Mersiha Torlak Peter T.Nieh Mehrdad Alemozaffar Kenneth Ogan Viraj A.Master | 2016 | Asian Journal of Urology2016，3，1： | 0 |
| 7 | Major histocompatibility complex I upregulation in clear cell renal cell carcinoma is associated with increased survival显示文摘Objective:To examine the prognostic value of tumor major histocompatibility complex I(MHCI)expression on survival and recurrence in patients with clear cell renal cell carcinoma(RCC).Methods:Fifty-three patients that underwent nephrectomy at our institution for clear cell RCC(T1eT3)with4 years of follow-up were queried from our nephrectomy database.Immunohistochemical staining for MHCI was performed on tumor specimens and MHCI expression was quantified with an automated image analysis technique.Patients were divided into high and low MHCI expression groups in order to study the relationship between MHCI expression and prognosis using the KaplaneMeier method and log-rank test.Results:Overall survival and recurrence free survival were increased in the high MHCI expression group compared to the low MHCI expression group(log-rank,p=0.036 and p=0.028,respectively).Patients alive at the end of the study had higher MHCI expression(mean positivity score 0.82)than those that died of disease(mean positivity score 0.76,t test,p=0.030).Patients that did not develop recurrence during the study period had higher MHCI expression(mean positivity score 0.83)than those that did develop recurrence(mean positivity score 0.78),but this difference was not significant(t test,p =0.079). | Rishi R.Sekar Claire M.De La Calle Dattatraya Patil Sarah A.Holzman Yoram Baum Umer Sheikh Jonathan H.Huang Adeboye O.Osunkoya Brian P.Pollack Haydn T.Kissick Kenneth Ogan Viraj A.Master | 2016 | Asian Journal of Urology2016，3，2： | 0 |
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