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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial显示文摘 | Simon Heller John Buse Miles Fisher Satish Garg Michel Marre Ludwig Merker Eric Renard David Russell-Jones Areti Philotheou Ann Marie Ocampo Francisco Huiling Pei Bruce Bode | 2012 | The Lancet2012，，9825： | 2 |
| 3 | Quantitative Eas- ing And Unconventionalmonetary Policy - An Introduction显示文摘 | Michael Joyce David Miles Andrew Scott and Dimitri Vayanos | 2012 | The Economic Journal2012，，122： | 1 |
| 4 | Quantitative Easing and Unconventional Monetary Policy-an Introduction显示文摘 | Michael Joyce David Miles Andrew Scott and Dimitri Vayanos | 2012 | The Economic Journal2012，122，564： | 1 |
| 5 | Public attitudes and consultation in traffic calming schemes 显示文摘 | Taylor David Tight Miles | 1997 | Transport Policy1997，4，3： | 1 |
| 6 | Adenomatoid odontogenic tumor mimicking a dentigerous cyst 显示文摘 | Miguel Bravo David White Lili Miles | 2005 | Int J Pediatr Otolaryngol2005，69，11： | 1 |
| 7 | Quantitative easing and unconventional monetary policy-an introduction显示文摘 | Michael Joyce David Miles | 2012 | The Economic Journal2012，，11： | 1 |
| 8 | A Benthic Terrain Classification Scheme for American Samoa显示文摘 | Emily R. Lundblad Dawn J. Wright Joyce Miller Emily M. Larkin Ronald Rinehart David F. Naar Brian T. Donahue S. Miles Anderson Tim Battista | 2006 | Marine Geodesy2006，，2： | 1 |
| 9 | Governance in a Global Economy:Political Authority in Transition显示文摘 | Kahler Miles Lake David A | 2004 | Political Science & Politics2004，，7： | 1 |
| 10 | The AustralianCancer Anaemia Survey:a snapshot of anaemia in adult patientswith cancer显示文摘 | Tara Seshadri H Miles Prince David R Bel | 2005 | MJA2005，182，9： | 1 |
| 11 | Bevacizumab and osteonecrosis of the jaw: incidence and association with bisphosphonate therapy in three large prospective trials in advanced breast cancer显示文摘 | Valentina Guarneri David Miles Nicholas Robert Véronique Diéras John Glaspy Ian Smith Christoph Thomssen Laura Biganzoli Tanya Taran PierFranco Conte | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 12 | Usefulness of fractional flow reserve to improve diagnostic efficiency in patients with non-ST elevation myocardial infarction 显示文摘 | David C Miles B Fiona F | 2013 | Am J Cardiol2013，111，1： | 1 |
| 13 | Measuring Efficiency and Risk in the Major Bond Market显示文摘 | Steven G Hall David K Miles | 1992 | Oxford Economic Papers1992，，10： | 1 |
| 14 | Vitamin B- 12 and neural tube defects: The Canadian experience 显示文摘 | Thompson Miles D Cole David E Ray Joel G | 2009 | The American Journal of Clinical Nutrition2009，89，2： | 1 |
| 15 | The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications显示文摘 | Bianca Zingales Michael A. Miles David A. Campbell Michel Tibayrenc Andrea M. Macedo Marta M.G. Teixeira Alejandro G. Schijman Martin S. Llewellyn Eliane Lages-Silva Carlos R. Machado Sonia G. Andrade Nancy R. Sturm | 2012 | Infection Genetics and Evolution2012，，2： | 1 |
| 16 | Use of the Double-Pass Technique to Quantify Ocular Scatter in Patients with Uveitis: A Pilot Study显示文摘 | Nanavaty Mayank A Stanford Miles R Sharma Rohit Dhital Anish Spalton David J Marshall John | 2010 | Ophthalmologica2010，，1： | 1 |
| 17 | Evaluation of seismic slope per- formance models using a regional case study 显示文摘 | Scott B Miles David K Keeper | 2000 | Environmental Engineering Geoscience2000，6，1： | 1 |
| 18 | Design techniques for cascoded CMOS op amps with improved PSRR and common-mode input range显示文摘 | Ribner David B Copeland Miles A | 1984 | IEEE Journal of Solid-State Circuits1984，19，6： | 1 |
| 19 | The diagnosis and reproductive outcome after surgical treatment of the complete septate uterus, duplicated cervix and vaginal septum显示文摘 | Phillip E Patton Miles J Novy David M Lee Lee R Hickok | 2004 | American Journal of Obstetrics and Gynecology2004，，6： | 1 |
| 20 | Risk, Return and Portfolio Allocation under Alternative Pension Systems with Incomplete and Imperfect Financial Markets显示文摘 | David Miles Ales Cemy | 2006 | The Economic Journal2006，，6： | 1 |
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