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| 1 | Environmental records of lacustrine sediments in different time scales:Sediment grain size as an example显示文摘Sediment grain size is a conventional proxy of climatic changes. Larger sediment grain size is often interpreted to indicate dry climate during lower lake level while smaller sedi- ment grain size implies wet climate during higher lake level. Through detailed study on sediment grain sizes in Lake Erhai and Lake Chenghai, this paper reveals the different indication signifi- cances of sediment grain sizes in different time scales, different resolution investigations. For long time-scale and low resolution (102a or 103a) studies, larger sediment grain size indicates lower lake level, smaller lake area and drier climate while smaller sediment grain size indicates higher lake level, larger lake area and wetter climate. For short time-scale and high resolution (a or 10a) studies, larger sediment grain size reflects more rainfall and wetter climate while smaller sediment grain size reflects less rainfall and drier climate. Environmental information revealed by lacustrine sediment records is often different in different time scales because of the variance of sedimentation resolution, sampling resolution and dating precision. Therefore, paleoclimate im- plications of environmental proxies in long time-scale and low resolution investigations could not be mechanically applied to short time-scale and high resolution studies. Only after synthetically analyzing the influence manner and extent of all factors on the sediment records in different time scales, can credible conclusions be obtained. | CHEN Jing’an1, WAN Guojiang1, David Dian Zhang2, ZHANG Feng1 & HUANG Ronggui1 1. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 2. Department of Geography and Geology, University of Hong Kong, Pokfulam Road, Hong Kong, China | 2004 | Science China Earth Sciences2004，47，10： | 27 |
| 2 | Recent advances on phylogenomics of gymnosperms and a new classification显示文摘Living gymnosperms comprise four major groups:cycads,Ginkgo,conifers,and gnetophytes.Relationships among/within these lineages have not been fully resolved.Next generation sequencing has made available a large number of sequences,including both plastomes and single-copy nuclear genes,for reconstruction of solid phylogenetic trees.Recent advances in gymnosperm phylogenomic studies have updated our knowledge of gymnosperm systematics.Here,we review major advances of gymnosperm phylogeny over the past 10 years and propose an updated classification of extant gymnosperms.This new classification includes three classes(Cycadopsida,Ginkgoopsida,and Pinopsida),five subclasses(Cycadidae,Ginkgoidae,Cupressidae,Pinidae,and Gnetidae),eight orders(Cycadales,Ginkgoales,Araucariales,Cupressales,Pinales,Ephedrales,Gnetales,and Welwitschiales),13 families,and 86 genera.We also described six new tribes including Acmopyleae Y.Yang,Austrocedreae Y.Yang,Chamaecyparideae Y.Yang,Microcachrydeae Y.Yang,Papuacedreae Y.Yang,and Prumnopityeae Y.Yang,and made 27 new combinations in the genus Sabina. | Yong Yang David Kay Ferguson Bing Liu Kang-Shan Mao Lian-Ming Gao Shou-Zhou Zhang Tao Wan Keith Rushforth Zhi-Xiang Zhang | 2022 | Plant Diversity2022，44，4： | 10 |
| 3 | The Subcellular Localization and Blue-Light- Induced Movement of Phototropin 1-GFP in Etiolated Seedlings of Arabidopsis thalianaw显示文摘Phototropin 1 (phot1 ) 是为向光性,叶绿体运动,有气孔的洞,叶扩大,并且响应蓝光的太阳的追踪的一个光敏电阻器。有 PHOT1::GFP 的后面的更早的工作(Sakamoto 和布里格斯, 2002 ) ,我们调查了模式细胞并且在 34 d 的 phot1 的 subcellular 本地化 Arabidopsis thalinana 的旧变白的幼苗。是从本国的在上游的序列表示了, PHOT1::GFP 熔化蛋白质在子叶的离开轴心的纸巾并且在胚轴的伸长的区域强烈被表示。它中等在根顶附近在射击 / 根转变地区并且在房间被表示。一个荧光信号在根外皮,根帽子,和根是无法发现的顶端的分裂组织本身。子叶边缘附近的叶肉房间的血浆膜显得一致地标记但是跨墙由最近的房间部门创造了更强烈被标记。单个房间类型标记的模式与房间类型和发展舞台变化。蓝光的处理原因 PHOT1::GFP,均匀地相对开始在血浆膜散布了,与强烈标记的有小斑点的区域和完全缺乏在胚轴延伸区域在外皮的房间观察的 fluorescencea 现象最好的另外的区域重新组织变得进不同马赛克。伴随物与或追随者这个重组,进在所有房间类型的细胞质的 PHOT1::GFP 行动除了警卫房间调查了。它在黑暗在几个小时以后由未辩别出的机制从细胞质消失。它在细胞质的外观也不它在黑暗的最终的消失被翻译禁止者酮环己酰亚胺也不阻止,尽管后者过程被延迟。我们假设那 blue-light-induced phot1 重新本地化调制 blue-light-activated 信号 transduction。 | Ying-Lang Wan William Eisinger David Ehrhardt Ulrich Kubitscheck Frantisek Baluska Winslow Briggs | 2008 | Molecular Plant2008，1，1： | 10 |
| 4 | 牧草如何生长——植物生长与放牧管理之关联(英文)显示文摘适当管理饲料饲草资源的基本原则是理解多年生牧草如何生长。长期以来 ,对根系生长有了基本的了解 ,对去叶和环境对根系生长的影响也知之甚多。然而 ,对去叶、干旱及其他环境因素对多年生牧草的影响以及这些牧草对去叶的反应缺乏应有的理解。从牧草返青到开花 ,植物处于短枝阶段 ,适度放牧并不对多年生牧草的健康和活力造成危害 ,因为植物会弥补其失去的叶片。然而 ,当牧草从短枝向长枝阶段 (节间伸长和开花期 )转移时 ,碳水化合物主要用于节间伸长和开花过程。在开花后和休眠前期 ,碳水化合物主要向茎基和植物基部转移 ,以供来年新枝条的发育。因此 ,在花后和休眠前期 ,放牧系统必须被调节到“无放牧”状态。“无放牧”状态 ,如休息、轮牧、延迟轮牧和快速轮牧制 ,其价值在于这种定期的禁牧可提高多年生牧草的活力 ,改善草地的健康状况 ,并且在不利的环境条件下 。 | Ronald E Sosebee David B Wester J Carlos Villalobos Carlton M Britton Changgui Wan Hisham Nofal | 2005 | 草业学报2005，14，1： | 8 |
| 5 | What Security Questions Do Developers Ask? A Large-Scale Study of Stack Overflow Posts显示文摘安全总是是一个流行、批评的话题。与信息技术的快速的发展,它总是正在吸引民族注意。然而,自从安全有长历史,它论及改变很多的大量话题,从经典密码学到最近流行活动安全。有需要调查安全相关的话题和趋势,它能是为安全研究人员,安全教育者和安全专业人员的一个指南。到地址上述在这篇论文,我们需要在栈溢出上在安全相关的问题上进行大规模研究。栈溢出是一个流行联机问题和答案地点让软件开发者传达,协作,并且分享与对方一起的信息。在在栈溢出上张贴的众多的问题之中有许多不同话题,安全相关的问题占据一个大比例并且有一个重要、重要的位置。我们首先使用二条启发规则从数据集提取基于帖子的标签与安全有关的问题。然后我们使用一个先进话题模型,潜伏的 Dirichlet 分配(LDA ) 调节了使用基因算法(GA ) ,基于他们的文章聚类不同安全相关的问题。在获得安全相关的问题的不同话题以后,我们使用他们的元数据做各种各样的分析。我们总结所有话题进五个主要范畴,并且也调查不同话题的流行和困难。基于我们的学习的结果,我们为研究人员,教育者和专业人员结束几个含意。 | Xin-Li Yang David Lo Xin Xia Zhi-Yuan Wan Jian-Ling Sun | 2016 | Journal of Computer Science & Technology2016，31，5： | 8 |
| 6 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 5 |
| 7 | Effect of nitrogen fertilization on yield, N content, and nitrogen fixation of alfalfa and smooth bromegrass grown alone or in mixture in greenhouse pots显示文摘Planting grass and legume mixtures on improved grasslands has the potential advantage of realizing both higher yields and lower environmental pollution by optimizing the balance between applied N fertilizer and the natural process of legume biological nitrogen fixation. However, the optimal level of N fertilization for grass-legume mixtures, to obtain the highest yield, quality, and contribution of N2 fixation, varies with species. A greenhouse pot experiment was conducted to study the temporal dynamics of N2 fixation of alfalfa(Medicago sativa L.) grown alone and in mixture with smooth bromegrass(Bromus inermis Leyss.) in response to the addition of fertilizer N. Three levels of N(0, 75, and 150 kg ha–1) were examined using 15N-labeled urea to evaluate N2 fixation via the 15 N isotope dilution method. Treatments were designated N0(0.001 g per pot), N75(1.07 g per pot) and N150(2.14 g per pot). Alfalfa grown alone did not benefit from the addition of fertilizer N; dry matter was not significantly increased. In contrast, dry weight and N content of smooth bromegrass grown alone was increased significantly by N application. When grown as a mixture, smooth bromegrass biomass was increased significantly by N application, resulted in a decrease in alfalfa biomass. In addition, individual alfalfa plant dry weight(shoots+roots) was significantly lower in the mixture than when grown alone at all N levels. Smooth bromegrass shoot and root dry weight were significantly higher when grown with alfalfa than when grown alone, regardless of N application level. When grown alone, alfalfa's N2 fixation was reduced with N fertilization(R2=0.9376, P=0.0057). When grown in a mixture with smooth bromegrass, with 75 kg ha–1 of N fertilizer, the percentage of atmospheric N2 fixation contribution to total N in alfalfa(%Ndfa) had a maximum of 84.07 and 83.05% in the 2nd and 3rd harvests, respectively. Total 3-harvest %Ndfa was higher when alfalfa was grown in a mixture than when grown alone(shoots: |t|=3.39, P=0.0096; root: |t|=3.57, P=0.0073). We believe this was due to smooth bromegrass being better able to absorb available soil N(due to its fibrous root system), resulting inlower soil N availability and allowing alfalfa to develop an effective N2 fixing symbiosis prior to the 1st harvest. Once soil N levels were depleted, alfalfa was able to fix N2, resulting in the majority of its tissue N being derived from biological nitrogen fixation(BNF) in the 2nd and 3rd harvests. When grown in a mixture, with added N, alfalfa established an effective symbiosis earlier than when grown alone; in monoculture BNF did not contribute a significant portion of plant N in the N75 and N150 treatments, whereas in the mixture, BNF contributed 17.90 and 16.28% for these treatments respectively. Alfalfa has a higher BNF efficiency when grown in a mixture, initiating BNF earlier, and having higher N2 fixation due to less inhibition by soil-available N. For the greatest N-use-efficiency and sustainable production, grass-legume mixtures are recommended for improving grasslands, using a moderate amount of N fertilizer(75 kg N ha–1) to provide optimum benefits. | XIE Kai-yun LI Xiang-lin HE Feng ZHANG Ying-jun WAN Li-qiang David B Hannaway WANG Dong QIN Yan Gamal M A Fadul | 2015 | Journal of Integrative Agriculture2015，14，9： | 5 |
| 8 | Revision of the Conchostracan Genus Tenuestheria from the Upper Cretaceous Lanxi Formation in Zhejiang and Its Biostratigraphic Significance in Southeast China显示文摘从在 Jinhua 的 Lanxi 形成的 conchostracan 类 Tenuestheria 的诊断,在东南中国的浙江省被修订在一台扫描电子显微镜下面跟随类型种类的考试,它在没以前被认出的甲壳上揭示了一些词法特征。Tenuestheria 动物志的重要性在中国的这个区域在六 Turonian-Santonian 形成的关联的上下文被考虑。在相关的 Cenomanian Nemestheria 和 Turonian Linhaiella 动物志的价值内在的早迟了的白垩纪形成也被注意。 | LI Gang WAN Xiaoqiao Helmut WILLEMS David J. BATTEN | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 4 |
| 9 | Comparison of ocular modulation transfer function determined by a ray-tracing aberrometer and a double-pass system in early cataract patients显示文摘 | Qiao Liya Wan Xiuhua Cai Xiaogu Balamurali Vasudevan Xiong Ying Tan Jiaxuan Guan Zheng David A Atchison Wang Ningli | 2014 | Chinese Medical Journal2014，，19： | 3 |
| 10 | Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation显示文摘AIM:To evaluate the anti-HIV activity and mechanism of action of wikstroelide M,a daphnane diterpene from Daphne acutiloba Rehder(Thymelaeaceae).METHOD:The anti-HIV activities of wikstroelide M against different HIV strains were evaluated by cytopathic effect assay and p24 quantification assay with ELISA.The inhibitory effect of wikstroelide M on HIV reverse transcription was analyzed by real-time PCR and ELISA.The effect of wikstroelide M on HIV-1 integrase nuclear translocation was observed with a cell-based imaging assay.The effect of wikstroelide M on LEDGF/p75-IN interaction was assayed by molecular docking.RESULTS:Wikstroelide M potently inhibited different HIV-1 strains,including HIV-1IIIB,HIV-1A17,and HIV-19495,induced a cytopathic effect,with EC50 values ranging from 3.81 to 15.65 ng·mL-1.Wikstroelide M also had high inhibitory activities against HIV-2ROD and HIV-2CBL-20-induced cytopathic effects with EC50 values of 18.88 and 31.90 ng·mL-1.The inhibitory activities of wikstroelide M on the three HIV-1 strains were further confirmed by p24 quantification assay,with EC50 values ranging from 15.16 to 35.57 ng·mL-1.Wikstroelide M also potently inhibited HIV-1IIIB induced cytolysis in MT-4 cells,with an EC50 value of 9.60 ng·mL-1.The mechanistic assay showed that wikstroelide M targeted HIV-1 reverse transcriptase and nuclear translocation of integrase through disrupting the interaction between integrase and LEDGF/p75.CONCLUSION:Wikstroelide M may be a potent HIV-1 and HIV-2 inhibitor,the mechanisms of action may include inhibition of reverse trascriptase activity and inhibition of integrase nuclear translocation through disrupting the interaction between integrase and LEDGF/p75. | ZHANG Xuan HUANG Sheng-Zhuo GU Wan-Gang YANG Liu-Meng CHEN Huan ZHENG Chang-Bo ZHAO You-Xing WAN David Chi-Cheong ZHENG Yong-Tang | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 3 |
| 11 | Design,synthesis characterization and in vitro biological activity of a series of 3-aryl-6-(bromoarylmethyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors显示文摘Bromination 被用作策略在药用的化学改进生物活动。以便在与 7H-thiazolo 的新奇 acetylcholinesterase 禁止者的 structureactivity 关系上学习[ 3,2-b ]-1, 2 , 4-triazin-7-one 支架基于我们的以前的工作并且分子的建模,一系列新奇3-aryl-6-( bromoarylmethyl )-7H-thiazolo[3,2-b]-1, 2 , 4-triazin-7-one 衍生物被分子的停靠设计,由集体系列,红外线的系列,质子 NMR 和元素的分析综合了并且描绘。疼痛的学习禁止的活动与 huperzine 用 Ellman 比色的试金被执行 -- 是的 A 积极控制。大多数所有目标混合物在 10 mol/L 展出了超过 45% 抑制。初步的 structureactivity 关系在在父母原子核的 C6 位置的苯基戒指是溴原子和氢氧根组在目标混合物的疼痛禁止的活动的起的重要角色。 | He Nan Xu Zhe Jin Si Jie Liu Hong Min Liu Shuo Li Huang Quan Lin David Chicheong Wan Chun Hu | 2012 | Chinese Chemical Letters2012，23，7： | 3 |
| 12 | M0S2 dual-gate transistors with electrostatically doped contacts显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)such as molybdenum disulfide(M0S2)have been intensively investigated because of their exclusive physical properties for advaneed electronics and optoelectronics.In the present work,we study the M0S2 transistor based on a novel tri-gate device architecture,with dual-gate(Dual-G)in the channel and the buried side-gate(Side-G)for the source/drain regi ons.All gates can be in depe ndently con trolled without in terfere nee.For a MoS2 sheet with a thick ness of 3.6 nm,the Schottky barrier(SB)and non-overlapped channel region can be effectively tuned by electrostatically doping the source/drain regions with Side-G.Thus,the extri nsic resista nee can be effectively lowered,and a boost of the ON-state cur re nt can be achieved.Mean while,the cha nn el c ontrol remai ns efficient under the Dual-G mode,with an ON-OFF current ratio of 3 x 107 and subthreshold swing of 83 mV/decade.The corresponding band diagram is also discussed to illustrate the device operati on mechanism.This no vel device structure ope ns up a new way toward fabricati on of high-performance devices based on 2D-TMDs. | Fuyou Liao Yaocheng Sheng Zhongxun Guo Hongwei Tang Yin Wang Lingyi Zong Xinyu Chen Antoine Riaud Jiahe Zhu Yufeng Xie Lin Chen Hao Zhu Qingqing Sun Peng Zhou Xiangwei Jiang Jing Wan Wenzhong Bao David Wei Zhang | 2019 | Nano Research2019，12，10： | 2 |
| 13 | Synthesis and biological activity of 3,6-diaryl-7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives as novel acetylcholinesterase inhibitors显示文摘Acetylcholinesterase inhibitors played significant roles in treatment of Alzheimer's disease.Based on the research foundation of our previous work and molecular modeling,twelve 3,6-diaryl-7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives were synthesized and characterized by mass spectra,infrared spectra,NMR and elemental analyses.The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive control.All target compounds exhibited more than 40% inhibition at 10 μM.Some target compounds showed good inhibition against AChE.The preliminary structure-activity relationships were the halogen atoms at the phenyl ring at the C6 position,the hydroxy groups and the long side chains at the phenyl ring at the C3 position of the parent nucleus played significant roles in the AChE inhibitory activity of the target compounds. | WAN David ChiCheong | 2010 | Science China Chemistry2010，53，11： | 2 |
| 14 | Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1显示文摘 | SampaPal Stephen JPolyak NazneenBano Wan ChongQiu Robert LCarithers MargaretShuhart David RGretch AditiDas | 2010 | Journal of Gastroenterology and Hepatology2010，，3： | 2 |
| 15 | Operational Reliability Modeling and Assessment of Battery Energy Storage Based on Lithium-ion Battery Lifetime Degradation显示文摘Battery energy storage(BES)systems can effectively meet the diversified needs of power system dispatching and assist in renewable energy integration.The reliability of energy storage is essential to ensure the operational safety of the power grid.However,BES systems are composed of battery cells.This suggests that BES performance depends not only on the configuration but also on the operating state over different lifetime durations.The lack of safety and reliability is the main bottleneck preventing widespread applications of BES systems.Therefore,a reliability assessment algorithm and a weak-link analytical method for BES systems are proposed while considering battery lifetime degradation.Firstly,a novel lithium-ion battery model is proposed to identify the degradation rate of solid electrolyte interphase film formation and capacity plummeting.The impacts of different operating conditions are considered in stress factor models.Then,a reliability assessment algorithm for a BES system is introduced based on a universal generating function.An innovative weak-link analytical method based on the reliability importance index is proposed that combines the evaluation results of state-oriented and state-change-oriented indexes through an entropy weight method.The model,algorithm,indexes,and the usefulness are demonstrated in case studies based on aging test data and actual bus operating data.The results demonstrate the effects of the battery status and working conditions on BES reliability.Weak-link analysis is also used to assist BES systems in avoiding short-board batteries to achieve long lifetimes and efficient operation. | Lin Cheng Yuxiang Wan Yanglin Zhou David Wenzhong Gao | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，6： | 2 |
| 16 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 1 |
| 17 | Tourists’ satisfaction, recommendation and revisiting Singapore显示文摘 | Tak Kee Hui David Wan Alvin Ho | 2006 | Tourism Management2006，，4： | 1 |
| 18 | Determinants Of Firm Innovation in Singapore 显示文摘 | David Wan Chin Huat Ong Francis Lee | 2005 | Technovation2005，25，3： | 1 |
| 19 | An Exploratory Study on Interlocking Directorates in Listed Finns inSingapore 显示文摘 | Chin - Huat Ong David Wan Kee - Sing Ong | 2003 | Corporate Governance2003，11，4： | 1 |
| 20 | Human resource strategy and firm performance in Pacific Rim countries 显示文摘 | Bea J Shrh-Jer Chen Tai Wai David Wan | 2003 | International Journal of Human Resource Management2003，14，8： | 1 |
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