|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 3 | 结膜滤过泡组织病理学特性显示文摘目的:描述并比较在修复小梁切除术和由于疏忽造成的滤过泡时得到的的结膜的组织学特征并评价抗纤维变性药物的作用。方法:我们对经过晚期滤过泡修复的28只眼的结膜标本采用常规石蜡制作的方法和光学显微镜下检查进行仔细观察:19只眼为渗漏的小梁切除术滤过泡,5只眼为无渗漏的小梁切除术滤过泡,4只眼为由于疏忽造成的滤过泡。定量分析的组织学特征包括结膜上皮的厚度,基质血管供应,鳞状组织化生,基质炎症细胞浸润和杯状细胞的密度。并且分析了手术类型,存在渗漏,先前的局部用药,应用抗纤维化药物都与组织学检查所见并置对比。结果:与由于疏忽造成的滤过泡的对照组相比,小梁切除术的滤过泡(渗漏的和无渗漏的)显示上皮的厚度(P〈0.02),杯状细胞的密度(P〈0.001)和血管供应(P〈0.001)全部降低。接受过抗纤维化药物的结膜比先前未受抗纤维化药物影响的结膜的上皮细胞层数更少(P〈0.05)。结论:小梁切除术后切除的薄的滤过泡的组织学分析证明上皮的厚度和杯状细胞的密度与由于疏忽造成的滤过泡相比均降低。与正常结膜相比。 | Brian A. Francis Lee T. Du Kathryn Najafi Raghu Murthy Usha Kurumety Narsing Rao Don S. Minckler 李航(译) 申敏如(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 8 |
| 4 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 5 | Emerging radiotherapy technologies and trends in nasopharyngeal cancer显示文摘AbTechnology has always driven advances in radiotherapy treatment.In this review,we describe the main technological advances in radiotherapy over the past decades for the treatment of nasopharyngeal cancer(NPC)and highlight some of the pressing issues and challenges that remain.We aim to identify emerging trends in radiation medicine.These include advances in personalized medicine and advanced imaging modalities,standardization of planning and delineation,assessment of treatment response and adaptive re-planning,impact of particle therapy,and role of artificial intelligence or automation in clinical care.In conclusion,we expect significant improvement in the therapeutic ratio of radiotherapy treatment for NPC over the next decade. | Michelle Tseng Francis Ho Yiat Horng Leong Lea ChoungWong Ivan WK Tham Timothy Cheo Anne WM Lee | 2020 | Cancer Communications2020，40，9： | 5 |
| 6 | Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma显示文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome. | Shilpa Jain Shashideep Singhal Franto Francis Cristina Hajdu Jin-Hua Wang Arief Suriawinata Yin-Quan wang Miao Zhang Elizabeth H Weinshel Fritz Francois Zhi-Heng Pei Peng Lee Ru-Liang Xu | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 7 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 8 | Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Vincenzo Mazzaferro MD Yun Shin Chun MD Ronnie T. P. Poon MS PhD Myron E. Schwartz MD Francis Y. Yao MD J. Wallis Marsh MD Sherrie Bhoori MD Sung-Gyu Lee MD PhD | 2008 | Annals of Surgical Oncology2008，，4： | 2 |
| 9 | Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots显示文摘 | Francis CW Blinc A Lee S | | 0，，： | 1 |
| 10 | Overriding imatinib resistance with a novel Abl kinase inhibitor显示文摘 | Neil P Shah Chris Tran Francis Y Lee | 2004 | Science2004，305，： | 1 |
| 11 | Time course of detection of viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion显示文摘 | Steven N Francis Lee Marcia L | 2000 | J Infect Dis2000，175，： | 1 |
| 12 | AC-microgrids versus DC-microgrids with distributed energy resources:a review显示文摘 | Jackson John Justo Francis Mwasilu Lee Ju | 2013 | Renewable and Sustainable Energy Reviews2013，24，： | 1 |
| 13 | AC-microgrids versus DC-microgrids with distributed energy resources: A review显示文摘 | Jackson J J Francis M Ju Lee | 2013 | Renewable and Sustainable Energy Reviews2013，24，： | 1 |
| 14 | Determinants Of Firm Innovation in Singapore 显示文摘 | David Wan Chin Huat Ong Francis Lee | 2005 | Technovation2005，25，3： | 1 |
| 15 | Parental Weight Status and Girls Television Viewing,Snacking,and Body Mass Indexes显示文摘 | Lee YBLL | 2003 | Obes Res2003，11，1： | 1 |
| 16 | Cultural discount of cinematic achievement: the academy awards and U.S. movies’ East Asian box office显示文摘 | Francis L. F. Lee | 2009 | Journal of Cultural Economics2009，，4： | 1 |
| 17 | Genetic Linkage of Bietti Crystallin Corneoretinal Dystrophy to Chromosome 4q35显示文摘 | Xiaodong Jiao Francis L. Munier Fumino Iwata Mutsuko Hayakawa Atsushi Kanai June Lee Daniel F. Schorderet Muh-Shy Chen Muriel Kaiser-Kupfer J. Fielding Hejtmancik | 2000 | The American Journal of Human Genetics2000，，5： | 1 |
| 18 | Time course of detection of viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion显示文摘 | Teven N Francis Lee Marcia L | 2000 | J InfectDis2000，175，： | 1 |
| 19 | Advanced Reproductive Age and Fertility显示文摘 | Kimberly Liu Allison Case Anthony P. Cheung Sony Sierra Saleh AlAsiri Belina Carranza-Mamane Allison Case Cathie Dwyer James Graham Jon Havelock Robert Hemmings Francis Lee Kimberly Liu Ward Murdock Vyta Senikas Tannys D.R. Vause Benjamin Chee-Man Wong | 2011 | International Journal of Gynecology and Obstetrics2011，，1： | 1 |
| 20 | Pharmacokinetics and safety of a unilamellar liposomal formulation of amphotericin B (AMBisome) in rabbits显示文摘 | Lee J W Amantea M A Francis P A | 1994 | Antimicrob Agents Chemother1994，38，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员