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| 1 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 2 | 经颅多普勒超声(TCD)的实践标准——第2部分:临床适应证和预期结果显示文摘引言:经颅多普勒(transcranial Doppler,TCD)已被证实为一种安全有效的生理学超声检查技术。尽管成像设备可以在结构影像的基础上显示颅内血流,但成像性双功能超声或非成像性TCD检查提供的最终结果是通过频谱波形来评价生理学血流参数。总结概要:多学科专家小组确定的TCD临床适应证包括:镰状细胞病、恼缺血、右向左分流(right—to—left shunt,RLS)、蛛网膜下腔出血、脑死亡以及围手术期或术中监测。TCD检查可常规应用于住院或门诊患者的一些临床实践活动:通过完整或部分TCD检查以检测正常、狭窄或闭塞的颅内血管和侧支循环来判断动脉闭塞位置,并进一步完善颈动脉超声或无创性血管造影结果;通过血管运动反应性检查来识别首发或复发性卒中的高危患者;通过栓子监测对脑栓塞进行实时检查、定位和量化;在怀疑反常性栓塞或考虑分流封堵术治疗的患者中进行RLS检测;对溶栓治疗进行监测以促进血管再通和检测再闭塞;在血管内支架置入术、颈动脉内膜切除术和心脏外科手术中进行监测以发现围手术期栓塞、血栓形成、低灌注或高灌注。结论:通过界定实践范围,这些标准将在TCD检查的申请、检查和评价过程中给开申请单的医生、发报告的医生以及第三方提供帮助。 | Andrei V. Alexandrov Michael A. Sloan Charles H. Tegeler David N. Newell Alan Lumsden Zsolt Garami Christopher R. Levy Lawrence K.S. Wong Colleen Douville Manfred Kaps 李海峰(译) 李宏(译) 李展秀(译) | 2012 | 国际脑血管病杂志2012，20，1： | 28 |
| 3 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 4 | Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy显示文摘Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management. | Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong | 2017 | World Journal of Gastroenterology2017，23，10： | 14 |
| 5 | 尖锐心肌的梗塞: 在在新加坡的年轻成年人的临床的特征和结果显示文摘 AIM: To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS: Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS: The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6±1.2 mmol/L, 3.8±1.1 mmol/L and 0.93±0.25 mmol/L respectively. The mean left ventricular function was 44%±10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION: Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI. | Chun Pong Wong Seet Yoong Loh Kwok Kong Loh Paul Jau Lueng Ong David Foo Hee Hwa Ho | 2012 | World Journal of Cardiology2012，4，6： | 13 |
| 6 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 7 | Impact of disease severity on gastric residual volume in critical patients显示文摘AIM: To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS: Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of the study. Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were recorded on the first, fourth, seventh, and fourteenth day of the study period. GRV was measured every 4 h during enteral feeding. The relationship be-tween mean daily GRV and SOFA scores and the correlation between mean daily GRV and mean APACHE Ⅱ score of all patients were evaluated and compared. RESULTS: Of the 61 patients, 43 patients were survivors and 18 patients were non-survivors. The mean daily GRV increased as SOFA scores increased (P < 0.001, analysis of variance). Mean APACHE Ⅱ scores of all patients correlated with mean daily GRV (P = 0.011, Pearson correlation) during the study period. Patients with decreasing GRV in the first 2 d had better survival than patients without decreasing GRV (P = 0.017, log rank test). CONCLUSION: GRV is higher in more severely ill medical ICU patients. Patients with decreasing GRV had lower ICU mortality than patients without decreasing GRV. | Chien-Wei Hsu Shu-Fen Sun David Lin Lee Shoa-Lin Lin Kam-Fai Wong Hsiu-Hua Huang Hung-Ju Li | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 8 | Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002. | Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser | 2009 | World Journal of Gastroenterology2009，15，35： | 7 |
| 9 | Therapeutic interventions for heart failure with preserved ejection fraction:A summary of current evidence显示文摘Heart failure with preserved ejection fraction(HFPEF)is common and represents a major challenge in cardiovascular medicine.Most of the current treatment of HFPEF is based on morbidity benefits and symptom reduction.Various pharmacological interventions available for heart failure with reduced ejection fraction have not been supported by clinical studies for HFPEF.Addressing the specific aetiology and aggressive risk factor modification remain the mainstay in the treatment of HFPEF.We present a brief overview of the currently recommended therapeutic options with available evidence. | Muhammad Asrar ul Haq Chiew Wong Vivek Mutha Nagesh Anavekar Kwang Lim Peter Barlis David L Hare | 2014 | World Journal of Cardiology2014，6，2： | 7 |
| 10 | AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function显示文摘LSD1 (在新名称下面的 KDM1 ) 是属于黄素依赖者胺 oxidase 家庭的首先识别的离氨酸特定的 histone demethylase。这里,我们报导那 AOF1 (在新名称下面的 KDM1B ) ,与 LSD1 有关的哺乳动物的蛋白质,也为 H3K4me1 和 H3K4me2 与特性拥有 histone demethylase 活动。象 LSD1 一样,高度保存的 SWIRM 领域为它的酶的活动被要求。然而, AOF1 在几个方面不同于 LSD1。首先, AOF1 不看起来形成包含 histone deacetylases 的稳定的蛋白质建筑群。第二, AOF1 被发现在房间周期的有丝分裂的阶段期间本地化到染色体,而 LSD1 不做。第三, AOF1 镇压抄写什么时候拴住到 DNA 和这项压抑活动,独立于它的 demethylase 活动。结构、功能的分析为 demethylase 作为必要识别了它的唯一的 N 终端 Zf-CW 领域活动无关的压抑功能。一起,我们的学习在黄素依赖者胺 oxidases 的家庭作为第二 histone demethylase 识别 AOF1 并且揭示 AOF1 的 demethylase 独立的压抑功能。 | Ze Yang Jun Jiang David M Stewart Shankang Qi Kenichi Yamane Jiwen Li Yi Zhang Jiemin Wong | 2010 | Cell Research2010，20，3： | 6 |
| 11 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 5 |
| 12 | Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding显示文摘Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical intervention. Commonly utilized medical therapy includes sucralfate enemas, antibiotics, 5-aminosalicylic acid derivatives, probiotics, antioxidants, short-chain fatty acids, formalin instillation and fractionated hyperbaric oxygen. More invasive treatments include endoscopic-based, focally ablative interventions such as dilation, heater and bipolar cautery, neodymium/yttrium aluminum garnet argon laser, radiofrequency ablation or argon plasma coagulation. Despite its relatively common frequency, there is a dearth of existing literature reporting headto-head comparisons of the various treatment options via a randomized controlled approach. The purpose of our review was to present the reader a consolidation of the existing evidence-based literature with the goal of highlighting the comparative effectiveness and risks of the various treatment approaches. Finally, we outline a pragmatic approach to the treatment of radiation proctitis. In light of the lack of randomized data, our goal is to pursue as least invasive an approach as possible, with escalation of care tailored to the severity of the patient's symptoms. For those cases that are clinicallyasymptomatic or only mildly symptomatic, observation or medical management can be considered. Once a patient fails such management or symptoms become more severe, invasive procedures such as endoscopically based focal ablation or surgical intervention can be considered. Although not all recommendations are supported by level I evidence, reported case series and single-institutional studies in the literature suggest that successful treatment with cessation of symptoms can be obtained in the majority of cases. | Joseph Paul Weiner Andrew Thomas Wong David Schwartz Manuel Martinez Ayse Aytaman David Schreiber | 2016 | World Journal of Gastroenterology2016，22，31： | 5 |
| 13 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 14 | Phylogenetic and climatic constraints drive flowering phenological patterns in a subtropical nature reserve显示文摘Aims Exploring flowering patterns and detecting processes are essential when probing into the nature of reproductive traits during the life history and the interactions among different evolutionary clades.such patterns are believed to be influenced by many factors,but quantifying these impacts at the community-level remains poorly understood.Methods We investigated the flowering patterns based on long-term her-barium records in a given area from subtropical forest regions in southern China.We obtained 5258 herbarium voucher specimens collected from the Dinghushan National Nature reserve(DNNr)belonging to 166 families,943 genera and 2059 species and exam-ined the month when each species was flowering during the period 1920-2007.Important Findings The results showed that plants flowered sequentially almost through-out the whole year,showing the characteristics of subtropical evergreen broad-leaved forests.Flowering spectrums of the entire flora and the four life forms exhibited a clear unimodality that is probably typical of subtropical forest communities.Flowering pat-terns of the DNNr were positively correlated with mean rainfall,mean air temperature and mean sunshine duration.median flowering dates of the 38 large species-rich families ranged from early april to late august;25 families exhibited significant unimodal distribution patterns,whereas the remaining families were unclear or bimodal.median flowering dates of the 10 most species-rich genera ranged from middle may to later July.While the results are consist-ent with climatic factors playing a general role in flowering patterns,median flowering dates varied significantly among species-rich families and genera,suggesting that phylogenies could provide spe-cific constraints in subtropical forests. | Nan-Cai Pei WJohn Kress Bu-Feng Chen David LErickson Khoon Meng Wong Jin-Long Zhang Wan-Hui Ye Zhong-Liang Huang Dian-Xiang Zhang | 2015 | Journal of Plant Ecology2015，8，2： | 4 |
| 15 | Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography显示文摘 | Robert P. Myers Aaron Pollett Richard Kirsch Gilles Pomier‐Layrargues Melanie Beaton Mark Levstik Andres Duarte‐Rojo David Wong Pam Crotty Magdy Elkashab | 2012 | Liver Int2012，，6： | 4 |
| 16 | Bioinformatics advances in saliva diagnostics显示文摘There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic,translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval,integration and analysis of data,we have developed the Saliva Ontology and SDxMart. This article reviews the informatics advances in saliva diagnostics made possible by the Saliva Ontology and SDxMart. | Barry Smith David TW Wong | 2012 | International Journal of Oral Science2012，4，2： | 3 |
| 17 | Hepatitis B virus infection and fatty liver in the general population显示文摘 | Vincent Wai-Sun Wong Grace Lai-Hung Wong Winnie Chiu-Wing Chu Angel Mei-Ling Chim Arlinking Ong David Ka-Wai Yeung Karen Kar-Lum Yiu Shirley Ho-Ting Chu Hoi-Yun Chan Jean Woo Francis Ka-Leung Chan Henry Lik-Yuen Chan | 2011 | Journal of Hepatology2011，，3： | 3 |
| 18 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 19 | Endoscopic mucosal resection and endoscopic submucosal dissection显示文摘 | Sergey V. Kantsevoy Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Richard Kwon Petar Mamula Sarah Rodriguez Raj J. Shah Louis Michel Wong Kee Song William M. Tierney | 2008 | Gastrointestinal Endoscopy2008，，1： | 2 |
| 20 | Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial显示文摘 | Vincent Wai-Sun Wong Ruth Suk-Mei Chan Grace Lai-Hung Wong Bernice Ho-Ki Cheung Winnie Chiu-Wing Chu David Ka-Wai Yeung Angel Mei-Ling Chim Jennifer Wing-Yan Lai Liz Sin Li Mandy Man-Mei Sea Francis Ka-Leung Chan Joseph Jao-Yiu Sung Jean Woo Henry Lik-Yue | 2013 | Journal of Hepatology2013，，3： | 2 |
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