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| 1 | Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells显示文摘肝是有有免疫力的规定的优美机制的一个 tolerogenic 机关保证本地、全身的有免疫力的忍耐的保养到自我和外国抗原,但是那也能对病原体装有效有免疫力的回答。尽管有主要 histo 相容性建筑群失配,肝 allografts 的有免疫力的特权在猪首先被认出,并且称为 “肝忍耐 effect”。而且,肝移植自发地与仅仅低剂量的免疫力的抑制被接受,并且为一样的施主的非肝的共同移植的 allografts 导致忍耐。尽管这 immunotolerogenic 环境在机关移植的背景是有利的,它在象肝炎 B 一样的长期的传染的肝疾病是有害的,导致 tumorigenesis 完成的病原体坚持和弱反肿瘤或 C,疟疾,血吸虫病或。肝是 T 房间激活的一个主要地点,但是它得到 T 房间的差或不完全的激活,导致他们的未成功的激活,疲劳,他们的受动器功能的抑制和早死亡。这被病原体利用并且能损害病原体控制和清理或允许肿瘤生长。T 房间的肝的 priming 被传统的很多个本地人和 nonconventional 调停介绍抗原的房间(APC ) 由有免疫力的偏差支持忍耐, T 房间变应力缺乏或 apoptosis 感应,并且产生并且膨胀规章的 T 房间。这评论将集中于通讯在之间古典并且在在感应的忍耐和愿望的肝的 nonclassical APC 和淋巴细胞在这个过程讨论最近的卓见进天生的淋巴细胞的角色。 | Andrea Kristina Horst Katrin Neumann Linda Diehl Gisa Tiegs | 2016 | Cellular & Molecular Immunology2016，13，3： | 26 |
| 2 | Role of microparticles in endothelial dysfunction and arterial hypertension显示文摘Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. | Thomas Helbing Christoph Olivier Christoph Bode Martin Moser Philipp Diehl | 2014 | World Journal of Cardiology2014，6，11： | 14 |
| 3 | CuZn37黄铜板料微塑性成形中的尺寸效应研究显示文摘为研究金属微塑性成形特点,对厚度不同及粗细两种晶粒尺寸的黄铜箔试样进行了单向拉伸和微弯曲实验,并采用经典塑性理论和应变梯度理论对弯曲回弹角进行了预测.粗晶粒板料试样单向拉伸实验表明,CuZn37黄铜的硬化曲线存在一种明显的尺寸效应,即板料厚度越小,屈服强度越高.弯曲回弹实验结果也存在另一种明显的尺寸效应现象,即板料厚度越小,回弹角越大.对这两种尺寸效应产生的原因进行了分析,指出应变梯度硬化对微成形工艺过程有重要影响. | 李河宗 董湘怀 王倩 申昱 DIEHL A HAGENAH H ENGEL U MERKLEIN M | 2011 | 材料科学与工艺2011，19，4： | 12 |
| 4 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 5 | Risk factors for colonoscopic perforation: A population-based study of 80118 cases显示文摘AIM: To assess the incidence and risk factors associated with colonic perforation due to colonoscopy. METHODS: This was a retrospective cross-sectional study. Patients were retrospectively eligible for inclusion if they were 18 years and older and had an inpatient or outpatient colonoscopy procedure code in any facility within the Geisinger Health System during the period from January 1, 2002 to August 25, 2010. Data are presented as median and inter-quartile range, for continuous variables, and as frequency and percentage for categorical variables. Baseline comparisons across those with and without a perforation were made using the two-sample t -test and Pearson's χ2 test, as appropriate.RESULTS: A total of 50 perforations were diagnosed out of 80118 colonoscopies, which corresponded to an incidence of 0.06% (95%CI: 0.05-0.08) or a rate of 6.2 per 10000 colonoscopies. All possible risk factors associated with colonic perforation with a P -value < 0.1 were checked for inclusion in a multivariable logbinomial regression model predicting 7-d colonic perforation. The final model resulted in the following risk factors which were significantly associated with risk of colonic perforation: age, gender, body mass index, albumin level, intensive care unit (ICU) patients, inpatient setting, and abdominal pain and Crohn's disease as indications for colonoscopy. CONCLUSION: The cumulative 7 d incidence of colonic perforation in this cohort was 0.06%. Advanced age and female gender were significantly more likely to have perforation. Increasing albumin and BMI resulted in decreased risk of colonic perforation. Having a colonoscopy indication of abdominal pain or Crohn's disease resulted in a higher risk of colonic perforation. Colonoscopies performed in inpatients and particularly the ICU setting had substantially greater odds of perforation. Biopsy and polypectomy did not increase the risk of perforation and only three perforations occurred with screening colonoscopy. | Uzair Hamdani Raza Naeem Fyeza Haider Pardeep Bansal Michael Komar David L Diehl H Lester Kirchner | 2013 | World Journal of Gastroenterology2013，19，23： | 9 |
| 6 | 成人期智力的年龄特征:中美比较研究显示文摘 | 申继亮 陈勃 王大华 Gisela Labouvie-Vief Manfred Diehl | 2001 | 心理科学2001，24，3： | 8 |
| 7 | Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease显示文摘 | Mark L. Palmeri Michael H. Wang Ned C. Rouze Manal F. Abdelmalek Cynthia D. Guy Barry Moser Anna Mae Diehl Kathryn R. Nightingale | 2011 | Journal of Hepatology2011，，3： | 5 |
| 8 | Immunosuppression for in vivo research: state-of-the-at protocols and experimental approaches显示文摘几乎,用非自体同源的房间,织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制,抑制免疫力的协议是在移植实验的一个关键元素。然而,没有详细知识,标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当,因此,保证推进调查。这评论与种类特定的药 metabolization 和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇 immunomodulatory 策略的当代的知识,例如间充质的干细胞或抗体的使用。因此,这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和 immunomodulation 策略提高现出症状之前的潜的移植研究的预兆的价值。 | Rita Diehl Fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze | 2017 | Cellular & Molecular Immunology2017，14，2： | 5 |
| 9 | The diagnosis and management of non‐alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association显示文摘 | Naga Chalasani Zobair Younossi Joel E. Lavine Anna Mae Diehl Elizabeth M. Brunt Kenneth Cusi Michael Charlton Arun J. Sanyal | 2012 | Hepatology2012，，6： | 5 |
| 10 | Improvedendoscopicretrogradecholangiopancreatographybrushincreases diagnosticyieldofmalignantbiliarystrictures显示文摘AIM: To determine if a new brush design could im-prove the diagnostic yield of biliary stricture brushings. METHODS: Retrospective chart review was performed of all endoscopic retrograde cholangiopancreatography procedures with malignant biliary stricture brushing between January 2008 and October 2012. A standard wire-guided cytology brush was used prior to proto-col implementation in July 2011, after which, a new 9 French wire-guided cytology brush(Infinity sampling device, US Endoscopy, Mentor, OH) was used for all cases. All specimens were reviewed by blinded pa-thologists who determined whether the sample waspositive or negative for malignancy. Cellular yield was quantified by describing the number of cell clusters seen. RESULTS: Thirty-two new brush cases were compared to 46 historical controls. Twenty-five of 32 (78%) cases in the new brush group showed abnormal cellular find-ings consistent with malignancy as compared to 17 of 46(37%) in the historical control group(P = 0.0003). There was also a significant increase in the average number of cell clusters of all sizes(21.1 vs 9.9 clusters, P = 0.0007) in the new brush group compared to his-torical controls. CONCLUSION: The use of a new brush design for brush cytology of biliary strictures shows increased di-agnostic accuracy, likely due to improved cellular yield, as evidenced by an increase in number of cellular clus-ters obtained. | Shieh FK Luong-Player A Khara HS Liu H Lin F Shellenberger MJ Johal AS Diehl DL | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 4 |
| 11 | Mechanisms of Disease Progression in NASH显示文摘 | Brittany N. Bohinc Anna Mae Diehl | 2012 | Clinics in Liver Disease2012，，3： | 3 |
| 12 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 13 | Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease显示文摘 | Janice Jou Steve Choi Anna Diehl | 2008 | Semin Liver Dis2008，，04： | 3 |
| 14 | Endoscopic mucosal resection and endoscopic submucosal dissection显示文摘 | Sergey V. Kantsevoy Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Richard Kwon Petar Mamula Sarah Rodriguez Raj J. Shah Louis Michel Wong Kee Song William M. Tierney | 2008 | Gastrointestinal Endoscopy2008，，1： | 2 |
| 15 | A role for c- myc in the regulation of thymocyte differentiation and possibly positive selection显示文摘 | Broussard- Diehl C Bauer SR Scheuermann RH | 1996 | J Immunol1996，156，9： | 2 |
| 16 | Dietary Composition and Nonalcoholic Fatty Liver Disease显示文摘 | Steven Solga Amir R. Alkhuraishe Jeanne M. Clark Mike Torbenson Ashli Greenwald Anna Mae Diehl Thomas Magnuson | 2004 | Digestive Diseases and Sciences2004，，10： | 2 |
| 17 | Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism显示文摘 | Yuping Chen Steve S. Choi Gregory A. Michelotti Isaac S. Chan Marzena Swiderska-Syn Gamze F. Karaca Guanhua Xie Cynthia A. Moylan Francesca Garibaldi Richard Premont Hagir B. Suliman Claude A. Piantadosi Anna Mae Diehl | 2012 | Gastroenterology2012，，5： | 2 |
| 18 | Cytokines in alcoholic and nonalcoholic steatohepatitis显示文摘 | Tilg H Diehl AM | | 0，，： | 2 |
| 19 | The prevalence and etiology of elevated aminotransferase levels in the United States显示文摘 | Jeanne M Clark Frederick L Brancati Anna Mae Diehl | 2003 | The American Journal of Gastroenterology2003，，5： | 2 |
| 20 | Nonalcoholic fatty liver disease: An agenda for clinical research显示文摘 | Zobair M. Younossi Anna Mae Diehl Janus P. Ong | 2002 | Hepatology2002，，： | 2 |
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