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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia. | Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 3 | Preparation of chitosan nanoparticles using methacrylic acid显示文摘 | de Moura MR Aouada FA Mattoso LC | | 0，，02： | 1 |
| 4 | Peripheral parenter- al nutrition : an option for patients with an indication for short-term parenteral nutrition显示文摘 | Correla MI Guimaraes J de Mattos LC | 2004 | Nutr Hosp2004，19，1： | 1 |
| 5 | Analysis of estrogen-and progesterone-receptor expression in endometrial polyps显示文摘 | Bamcat EC de Albuquerque Neto LC etal | 2007 | J Minim Invasive Gynecol2007，14，3： | 1 |
| 6 | Durability of percutaneous transluminal angioplasty for obstructive lesions of proximal subclavian artery:long-term results显示文摘 | De Vries JP Jager LC Van den Berg JC | 2005 | J Vasc Surg2005，41，： | 1 |
| 7 | The MEK/ERK pathway mediates COX-2-selective NSAID -induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells显示文摘 | Elder DJ Halton DE Playle LC | 2002 | Int J Cancer2002，99，3： | 1 |
| 8 | Effects of calcium hydroxide on cytokine expression in endodontic infections显示文摘 | Tavares WL de Brito LC Henriques LC | 2012 | J Endod2012，38，： | 1 |
| 9 | Prednisolone dosedependently influences inflammation and coagulation during human endotoxemia显示文摘 | de Kruif MD Lemaire LC Giebelen IA | 2007 | J Immunol2007，178，3： | 1 |
| 10 | Defensins as anti- inflammatory compounds and mueosal adjuvants显示文摘 | Kohlgraf KG Pingel LC Dietrich DE | 2010 | Future Mierobiol2010，5，： | 1 |
| 11 | Cryptococcal me ningoencephalitis and pulmonary noduleinnon-HIV-infecte- dimmunoeompetentpatient 显示文摘 | Lambertucci JR Franco R de Queiroz LC | 2005 | Rev Soc Bras Med Trop2005，38，2： | 1 |
| 12 | Phar-macodynamic interactions of antibiotics alone and in combination显示文摘 | Schentag JJ Strenkoski-Nix LC Nix DE | 1998 | Clin Infect Dis1998，27，1： | 1 |
| 13 | Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia 显示文摘 | de Kruif MD Lemaire LC Giehelen IA | 2007 | J Immunol2007，178，3： | 1 |
| 14 | Measuring affective reactivity in individuals with autism spectrum personality traits using the visual mismatch negativity event-related brain potential显示文摘 | Gayle LC Gal DE Kieffaber PD | 2012 | Front Hum Neurosci2012，6，： | 1 |
| 15 | Heel pain syndrome: Electrodianostic support for nerve entrapm ent显示文摘 | Schon LC Glennon TP Baxter DE | 1993 | Foot Ankle1993，14，3： | 1 |
| 16 | Neural correlates of cognitive impairment in posterior cortical atrophy显示文摘 | Kas A de Souza LC Samri D | 2011 | Brain2011，134，： | 1 |
| 17 | Matrix metalloproteinase and proin-flammatory cytokine production by chondrocytcs of human osteoarthriticcartilage: associations with degenerative changes显示文摘 | Tetlow LC Adlam DJ Woolley DE | 2012 | Arthritis Rheum2012，44，3： | 1 |
| 18 | Age-specific differences in treatment and survival of patients with cervical cancer in the southeast of the Netherlands,1986-t996显示文摘 | de Rijke JM van der Putten HW Lutgens LC | 2002 | Eur J Cancer2002，38，15： | 1 |
| 19 | In uence of the Additional Er:YAG Laser Conditioning Step on the Microleakage of Class V Restorations显示文摘 | Marcella EO Wendell LC Carlos de PE et M | 2006 | J of Biomed Mater Res2006，10，： | 1 |
| 20 | Peripheral parenteral nutrition: an option for patients with an indication for short-term parenteral nutrition 显示文摘 | Correia MI Guimaraes J de Mattos LC | 2004 | Nutr Hosp2004，19，1： | 1 |
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