维普中文期刊产品整合服务
4篇 您的检索式:作者名="Deng Lan CUI"
    题名 作者 年代 出处 被引量
1The Unfolding of Equivariant Bifurcation Problems with Two Types of State Variables in the Presence of Parameter Symmetry显示文摘与二展开 equivariant 分叉问题在组的行动下面州的变量打字(螕,螖) 被使用 DA 鈥揳l gebraic 工具讨论。主要结果之一是展开定理的 equivariant versal。关键词 equivariant 分叉问题 - 展开的 versal -( 螕,螖)鈥揺q uivalence 先生(2000 ) 题目分类 58C27 由 P. R 的国家自然科学基础支持了。中国(号码 10271023 ) 和湖南省(号码 04JJ3072 )Deng Lan CUI Yang Cheng LI 2006Acta Mathematica Sinica,English Series2006,22,5:6
2Awareness Status of Chronic Disabling Neurological Diseases among Elderly Veterans显示文摘Ji-Ping Tan Lin-Qi Zhu Jun Zhang Shi-Min Zhang Xiao-Yang Lan Bo Cui Yu-Cheng Deng Ying-Hao Li Guang-Hua Ye Lu-Ning Wang 2015Chinese Medical Journal2015,,10:4
3Serological investigations on West Nile virus in birds and horses in Shanghai, China 显示文摘Lan DL Wang CS Deng B Zhou JP Cui L Tang C Yue H Hua XG 2013Epidemiol Infect2013,141,3:1
4Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines.Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia 2024Protein & Cell2024,15,2:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费