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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 3 | Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines显示文摘AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The water extract from Rhizoma Coptidis,Radix Scutellariae and Radix isatidis could significantly inhibit the H.pylori activity with their MIC less than 7.8 mg/mL,suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H.pylori infection.CONCLUSION:Rhizoma Coptidis,Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H.pylori. | Feng Ma Ye Chen Jing Li He-Ping Qing Ji-De Wang YaLi Zhang Yang Bai Bei-Guo Long | 2010 | World Journal of Gastroenterology2010，16，44： | 34 |
| 4 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 5 | Re-Os and U-Pb Geochronology of the Erlihe Pb-Zn Deposit,Qinling Orogenic Belt,Central China,and Constraints on Its Deposit Genesis显示文摘The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs concordantly at the transitional location of an upright fold.Re and Os isotopic analyses for paragenetic pyrites with sphalerite and galena from the ore body have been used to determine the timing of mineralization and to trace the source of metallogenic materials.The Re-Os isotopic data of four pyrite samples construct an isochron,yielding a weighted average age of 226±17 Ma(mean square weighted deviation=1.7),which is considered the main mineralization age.A dioritic porphyrite vein sample,showing weaker mineralization,was also dated using the SHRIMP zircon UPb isotopic method to constrain the youngest metallogenic age of the ore deposit,because it distributes along a group of tensional joints cutting not only the upright fold in the deposit field,but also the main ore bodies.The dioritic porphyrite sample yields a weighted mean ^(206)Pb/^(238)U age of 221±3 Ma,which is slightly younger than the Re-Os isotopic isochron age of the pyrites,considered as the upper age limit of the mineralization,namely the ending age of the mineralization.The Os isotopic compositions of sulfide minerals distribute within a range between Os isotopic compositions of the crust and the mantle, indicating that the ore deposit can be derived from magma-related fluid,and the metallogenic materials are most likely derived from the mixing source of the crust and the mantle.The Erlihe Pb-Zn deposit and associated dioritic porphyrite vein,important records of Qinling tectonic-magmatism-mineralization activities,were formed during the Triassic collisional orogeny processes. | ZHANG Fan LIU Shuwen LI Qiugen SUN Yali WANG Zongqi YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 30 |
| 6 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 7 | Polymer-based EMI shielding composites with 3D conductive networks:A mini-review显示文摘High-frequency electromagnetic waves and electronic products can bring great convenience to people’s life,but lead to a series of electromagnetic interference(EMI)problems,such as great potential dangers to the normal operation of elec-tronic components and human safety.Therefore,the research of EMI shield-ing materials has attracted extensive attention by the scholars.Among them,polymer-based EMI shielding materials with light weight,high specific strength,and stable properties have become the current mainstream.The construction of 3D conductive networks has proved to be an effective method for the prepara-tion of polymer-based EMI shielding materials with excellent shielding effective-ness(SE).In this paper,the shielding mechanism of polymer-based EMI shield-ing materials with 3D conductive networks is briefly introduced,with emphasis on the preparation methods and latest research progress of polymer-based EMI shielding materials with different 3D conductive networks.The key scientific and technical problems to be solved in the field of polymer-based EMI shielding materials are also put forward.Finally,the development trend and application prospects of polymer-based EMI shielding materials are prospected. | Lei Wang Zhonglei Ma Yali Zhang Lixin Chen Dapeng Cao Junwei Gu | 2021 | SusMat2021，1，3： | 22 |
| 8 | Lightweight and robust rGO/sugarcane derived hybrid carbon foams with outstanding EMI shielding performance显示文摘Increasingly severe electromagnetic pollution is now in urgent need of materials with lightweight,excellent flame retardancy,and outstanding electromagnetic interference shielding effectiveness(EMI SE).Renewable source-derived carbon foams and graphene have attracted extensive attention due to their 3D porous structure and remarkable electrical conductivity().In this work,annealed sugarcane(ASC)was prepared by removal of lignin from sugarcane via hydrothermal reaction,followed by annealing treatment.Then graphene oxide(GO)was filled by vacuum-assisted impregnation process and thermally annealed to obtain the ASC/reduced graphene oxide(rGO)hybrid foams.When the loading of rGO is 17 wt.%,the ASC/rGO hybrid foam(density,of 0.047 g/cm^3)exhibits the optimal of 6.0 S/cm,EMI SE of 53 dB,specific SE(SSE=SE/)/thickness(t)of 3830 dB·cm^2/g,and compressive strength of 1.33 MPa,which is 76%,36%,13%and 6%higher than those of ASC,respectively.Moreover,ASC/rGO presents excellent flame retardancy,thermal stability,and heat insulation,which remains constant under burning on an alcohol lamp and presents low thermal conductivity of 115.19 mW(m·K),close to the requirement for heat insulation.Synergistic effect of ASC and rGO not only significantly increase of ASC/rGO,but fully utilizes the capability of ASC and rGO to attenuate electromagnetic waves by virtue of unique porous structures and abundant interfaces.Such kind of lightweight EMI materials with excellent mechanical property,shielding performance,flame retardancy,and heat insulation is expected to tackle the key scientific and technical bottleneck problems of EMI materials,and will greatly expand the application of carbon nanomaterials in the field of aerospace industry. | Lei Wang Xuetao Shi Junliang Zhang Yali Zhang Junwei Gu | 2020 | Journal of Materials Science & Technology2020，52，17： | 18 |
| 9 | Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway显示文摘Matrine 被使用了在反煽动性并且反癌症治疗很长时间。然而,在 colorectal 癌症(CRC ) 的反变形的效果和相关机制仍然是不清楚的。在这研究,我们调查了 matrine 的管理是否能经由调整表明小径的 p38 禁止人的 CRC 房间的增长,活动性,和侵略。结果证明 matrine 在 vitro 并且在 vivo 禁止了 CRC 房间的移植和侵略。在为 24 h 与 matrine 被对待以后,另外,表示在 CRC 房间矩阵 metalloproteinase-2 (MMP-2 ) 和 MMP-9 以及朊酶活动铺平以一种剂量依赖者方式被减少。而且, matrine 显然减少了 p38 的 phosphorylation 水平。有 p38 禁止者(SB203580 ) 和 matrine 的联合治疗在 CRC 房间导致了侵略以及 MMP-2/-9 表示的 synergistic 减小。matrine 在 vivo 禁止了 CRC 肿瘤的增长和转移,这也被发现。在结论, p38 发信号小径可以由减少 MMP-2/-9 的表示在 CRC 房间的移植和侵略上在 matrine 的禁止的效果包含,建议 matrine 可以是为 CRC 的一个潜在的治疗学的代理人。 | Hongtao Ren Shuqun Zhang Hongbing Ma Yali Wang Di Liu Xijing Wang Zhongwei Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 16 |
| 10 | A Perspective for Developing Polymer-Based Electromagnetic Interference Shielding Composites显示文摘The rapid development of aerospace weapons and equipment,wireless base stations and 5G communication technologies has put forward newer and higher requirements for the comprehensive performances of polymer-based electromagnetic interference(EMI)shielding composites.However,most of currently prepared polymer-based EMI shielding composites are still difficult to combine high performance and multi-functionality.In response to this,based on the research works of relevant researchers as well as our research group,three possible directions to break through the above bottlenecks are proposed,including construction of efficient conductive networks,optimization of multi-interfaces for lightweight and multifunction compatibility design.The future development trends in three directions are prospected,and it is hoped to provide certain theoretical basis and technical guidance for the preparation,research and development of polymer-based EMI shielding composites. | Yali Zhang Junwei Gu | 2022 | Nano-Micro Letters2022，14，6： | 16 |
| 11 | Multifunctional Ti_(3)C_(2)T_(x)-(Fe_(3)O_(4)/polyimide)composite films with Janus structure for outstanding electromagnetic interference shielding and superior visual thermal management显示文摘Flexible multifunctional polymer-based electromagnetic interference(EMI)shielding composite films have important application values in the fields of 5G communication technology,wearable electronic devices and artificial intelligence.In this work,Fe_(3)O_(4)/polyamic acid(PAA)nanofiber films are prepared by in-situ polymerization and electrospinning technology,and Ti_(3)C_(2)T_(x)nanosheets are deposited on the surface of the Fe_(3)O_(4)/PAA nanofiber films via vacuum-assisted filtration.Then,Janus Ti_(3)C_(2)T_(x)-(Fe_(3)O_(4)/polyimide(PI))composite films are obtained by thermal imidization.The two sides of the Janus films exhibit completely different properties.The Fe_(3)O_(4)/PI side has excellent hydrophobicity and insulation property,and the Ti_(3)C_(2)T_(x)side has hydrophilicity and terrific conductivity.When the mass fraction of Ti_(3)C_(2)T_(x)is 80 wt.%,the Janus Ti_(3)C_(2)T_(x)-(Fe_(3)O_(4)/PI)composite film has excellent EMI shielding performances and mechanical properties,with EMI shielding effectiveness,tensile strength and Young’s modulus reaching 66 dB,114.5 MPa and 5.8 GPa,respectively.At the same time,electromagnetic waves show different absorption shielding effectiveness(SEA)when incident from two sides of the Janus films.When the electromagnetic waves are incident from the Fe_(3)O_(4)/PI side,the SEA of the Janus film is 58 dB,much higher than that when the electromagnetic waves are incident from the Ti_(3)C_(2)T_(x)side(39 dB).In addition,the Ti_(3)C_(2)T_(x)side of the Janus Ti_(3)C_(2)T_(x)-(Fe_(3)O_(4)/PI)composite films also has excellent electrothermal and photothermal conversion performances.When the applied voltage is 4 V,the stable surface temperature reaches 108°C;when it is irradiated by simulated sunlight with power density of 200 mW/cm2,the stable surface temperature reaches 95℃. | Yali Zhang Zhonglei Ma Kunpeng Ruan Junwei Gu | 2022 | Nano Research2022，15，6： | 16 |
| 12 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 13 | Performance deterioration modeling and optimal preventive maintenance strategy under scheduled servicing subject to mission time显示文摘Servicing is applied periodically in practice with the aim of restoring the system state and prolonging the lifetime. It is generally seen as an imperfect maintenance action which has a chief influence on the maintenance strategy. In order to model the maintenance effect of servicing, this study analyzes the deterioration characteristics of system under scheduled servicing. And then the deterioration model is established from the failure mechanism by compound Poisson process. On the basis of the system damage value and failure mechanism, the failure rate refresh factor is proposed to describe the maintenance effect of servicing. A maintenance strategy is developed which combines the benefits of scheduled servicing and preventive maintenance. Then the optimization model is given to determine the optimal servicing period and preventive maintenance time, with an objective to minimize the system expected life-cycle cost per unit time and a constraint on system survival probability for the duration of mission time. Subject to mission time, it can control the ability of accomplishing the mission at any time so as to ensure the high dependability. An example of water pump rotor relating to scheduled servicing is introduced to illustrate the failure rate refresh factor and the proposed maintenance strategy. Compared with traditional methods, the numerical results show that the failure rate refresh factor can describe the maintenance effect of servicing more intuitively and objectively. It also demonstrates that this maintenance strategy can prolong the lifetime, reduce the total lifetime maintenance cost and guarantee the dependability of system. | Li Dawei Zhang Zhihua Zhong Qianghui Zhai Yali | 2014 | Chinese Journal of Aeronautics2014，27，4： | 14 |
| 14 | Structural Design Strategies of Polymer Matrix Composites for Electromagnetic Interference Shielding:A Review显示文摘With the widespread application of electronic communication technology,the resulting electromagnetic radiation pollution has been significantly increased.Metal matrix electromagnetic interference(EMI)shielding materials have disadvantages such as high density,easy corrosion,difficult processing and high price,etc.Polymer matrix EMI shielding composites possess light weight,corrosion resistance and easy processing.However,the current polymer matrix composites present relatively low electrical conductivity and poor EMI shielding performance.This review firstly discusses the key concept,loss mechanism and test method of EMI shielding.Then the current development status of EMI shielding materials is summarized,and the research progress of polymer matrix EMI shielding composites with different structures is illustrated,especially for their preparation methods and evaluation.Finally,the corresponding key scientific and technical problems are proposed,and their development trend is also prospected. | Chaobo Liang Zhoujie Gu Yali Zhang Zhonglei Ma Hua Qiu Junwei Gu | 2021 | Nano-Micro Letters2021，13，11： | 14 |
| 15 | Significant Reduction of Interfacial Thermal Resistance and Phonon Scattering in Graphene/Polyimide Thermally Conductive Composite Films for Thermal Management显示文摘The developing flexible electronic equipment are greatly affected by the rapid accumulation of heat,which is urgent to be solved by thermally conductive polymer composite films.However,the interfacial thermal resistance(ITR)and the phonon scattering at the interfaces are the main bottlenecks limiting the rapid and efficient improvement of thermal conductivity coefficients(λ)of the polymer composite films.Moreover,few researches were focused on characterizing ITR and phonon scattering in thermally conductive polymer composite films.In this paper,graphene oxide(GO)was aminated(NH_(2)-GO)and reduced(NH_(2)-rGO),then NH_(2)-rGO/polyimide(NH_(2)-rGO/PI)thermally conductive composite films were fabricated.Raman spectroscopy was utilized to innovatively characterize phonon scattering and ITR at the interfaces in NH_(2)-rGO/PI thermally conductive composite films,revealing the interfacial thermal conduction mechanism,proving that the amination optimized the interfaces between NH_(2)-rGO and PI,reduced phonon scattering and ITR,and ultimately improved the interfacial thermal conduction.The in-planeλ(λ∥)and through-planeλ(λ_(⊥))of 15 wt%NH_(2)-rGO/PI thermally conductive composite films at room temperature were,respectively,7.13 W/mK and 0.74 W/mK,8.2 timesλ∥(0.87 W/mK)and 3.5 timesλ_(⊥)(0.21 W/mK)of pure PI film,also significantly higher thanλ∥(5.50 W/mK)andλ_(⊥)(0.62 W/mK)of 15 wt%rGO/PI thermally conductive composite films.Calculation based on the effective medium theory model proved that ITR was reduced via the amination of rGO.Infrared thermal imaging and finite element simulation showed that NH_(2)-rGO/PI thermally conductive composite films obtained excellent heat dissipation and efficient thermal management capabilities on the light-emitting diodes bulbs,5G high-power chips,and other electronic equipment,which are easy to generate heat severely. | Kunpeng Ruan Yongqiang Guo Chuyao Lu Xuetao Shi Tengbo Ma Yali Zhang Jie Kong Junwei Gu | 2021 | Research2021，，1： | 14 |
| 16 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 17 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 18 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 19 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 20 | Mechanically strong and folding-endurance Ti_(3)C_(2)T_(x) MXene/PBO nanofiber films for efficient electromagnetic interference shielding and thermal management显示文摘Electromagnetic interference(EMI)shielding materials with excellent flexibility and mechanical properties and outstanding thermal conductivity have become a hot topic of research in functional composites.In this study,the“sol-gel-film conversion technique”is used to assemble polyetherimidefunctionalized Ti_(3)C_(2)T_(x) nanosheets(f-Ti_(3)C_(2)T_(x))with poly(p-phenylene-2,6-benzobisoxazole)(PBO)nanofibers(PNFs),followed by dialysis and vacuum drying to prepare f-Ti_(3)C_(2)T_(x)/PNF films with lamellar structures.When the loading of f-Ti_(3)C_(2)T_(x) is 70 wt%,the f-Ti_(3)C_(2)T_(x)/PNF film presents optimal comprehensive properties,with an EMI shielding effectiveness(SE)of 35 dB and a specific SE/thickness((SSE,SE/density)/t)of 8211 dB cm^(2)/g,a tensile strength of 125.1 MPa,an in-plane thermal conductivity coefficient(λ)of 5.82 W/(m K),and electrical conductivity of 1943 S/m.After repeated folding for 10,000 cycles,the EMI SE and the tensile strength of f-Ti_(3)C_(2)T_(x)/PNFs films still remain 33.4 dB and 116.1 MPa,respectively.Additionally,the f-Ti_(3)C_(2)T_(x)/PNF film also shows excellent thermal stability,flame retardancy,and structural stability.This would provide a novel method for the design and fabrication of multifunctional composite films and considerably expand the applications of MXene-and PNF-based composites in the fields of EMI shielding and thermal management. | Lei Wang Zhonglei Ma Yali Zhang Hua Qiu Kunpeng Ruan Junwei Gu | 2022 | Carbon Energy2022，4，2： | 12 |
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