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| 1 | Gastroesophageal reflux: the features in elderlypatients显示文摘AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients. | Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F | 1999 | World Journal of Gastroenterology1999,5,5: | 12 |
| 2 | Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells显示文摘食道的有鳞的房间癌(ESCC ) 是最普通的恶意之一。识别预言肿瘤前进和治疗学的分子的目标的新 markersfor 是必要的。它被报导了 Aurora-Aand 矩阵 metalloproteinases 的那 overexpressions (MMP-2 ) 2 可以支持肿瘤的恶意的发展。然而,关系 betweenAurora -- 在肿瘤病人的 A 和 MMP-2 表示没被调查。另外, Aurora-Aregulates MMP-2 表示不充分仍然是的内在的机制阐明了。在这研究,我们表明了那曙光 A, MMP-2 与配对的正常邻近的纸巾相比是 overexpressedin ESCC 纸巾(P ? 0.0001 ) 。曙光 A 的 Overexpression 与 ESCC 的淋巴节点转移被联系(P ?=? 0.01 ) 。显著地,曙光 A 蛋白质表示断然在 ESCC 纸巾与 MMP-2 蛋白质表示被相关(r ?=? 0.66, P ? 0.0001 ) 象在 ESCC 一样,房间排队。曙光 A 表示的水平断然也与 ESCC 房间的 invasioncapability 被相关。而且,曙光 A overexpression 显著地由 upregulationof MMP-2 表示增加了 ESCC 房间侵略。另外,曙光 A overexpression 支持了原子 factor-kappaB (NF-B ) 激活,和 Aurora-A-mediatedMMP-2 upregulation 被 NF-B 废除禁止者。进一步的分析证明 NF-B 的激活是严重地在房间 overexpressing 曙光 A 的 attenuatedby AKT 禁止者。一起拿,这些数据通过激活在 ESCC 房间表明小径的 AKT/NF-B 显示那曙光 A overexpression upregulatesMMP-2 表情。这些调查结果揭示那曙光 A 可以是的 beused 为 ESCC 的恶意的行为的判断的重要指示物,并且可以是为 cancertherapy 的一个吸引人的目标。 | Xiaoxia Wang Xiaozhong Li Chaohui Li Chun He Benhong Ren Oing Deng Wei Gao Binquan Wang | 2016 | Acta Biochimica et Biophysica Sinica2016,48,6: | 6 |
| 3 | Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis显示文摘Pathogeneticfactorsafectinggastroesophagealrefluxinpatientswithesophagitisandconcomitantduodenalulcer:amultivariateanalysisZH... | Zhu, HM Huang, X Deng, CZ Porro, GP Pace, F Sangaletti, O | 1998 | World Journal of Gastroenterology1998,4,2: | 2 |
| 4 | Factors affecting Agrobactcrium-mediated transformation and regeneration of sweet orange and citrange 显示文摘 | Yu C H Huang S Chen C X Deng Z A Ling P and Gmitter F O J | 2002 | Plant Cell Tissue and Organ Culture2002,71,: | 1 |
| 5 | Large-pore apertures in a series of metal-organic frameworks显示文摘 | Deng H Grunder S Cordova K E Valente C Furukawa H Hmadeh M Gandara F Whalley A C Liu Z Asahina S Kazumori H O'Keeffe M Terasaki O Stoddart J F Yaghi O M | 2012 | Science2012,336,: | 1 |
| 6 | Preliminary application of high- definition CT gemstone spectral imaging in hand and foot tendons 显示文摘 | Deng K Zhang C O Li W | 2012 | Korean J Radiol2012,13,6: | 1 |
| 7 | Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation显示文摘 | Greenberg RA O'Hagan RC Deng H | 1999 | Oncogene1999,18,5: | 1 |
| 8 | Glycemic and glycosuric respon ses in white sturgeon (Acipenser transmontanus) after oral admin istration of simple and complex carbohydrates 显示文摘 | Deng D F Refstie S Hung S S O | 2001 | Aquaculture2001,199,: | 1 |
| 9 | Multiple functional groups of varying ratios in metal-organic frameworks显示文摘 | Deng H Doonan C J Furukawa H Ferreira R B Towne J Knobler C B Wang B Yaghi O M | | 0,,: | 1 |
| 10 | Relational repression in China: using social ties to demobilize protesters 显示文摘 | DENG Y H O'BRIEN K J | 2012 | China Quarterly2012,215,215: | 1 |
| 11 | Allogeneic bone marrow derived flk-1+Sca-1 mesenchymal stem cells leads to stable mixed chimerism and donor-specific tolerance显示文摘 | Deng WM Han O Liao LM | 2004 | Exp Hematology2004,32,9: | 1 |
| 12 | The inhibitory effects of silver nanoparticles, silver ions, and silver chloride colloids on microbial growth显示文摘 | Choi O Deng KK Kim NJ | 2008 | Water Research2008,42,12: | 1 |
| 13 | Telornerase reverse transcriptase gene is a direct target of c - Myc but is not functionally equivalent in cellular transformation 显示文摘 | Greenberg RA O' Hagan RC Deng H | 1999 | Oncogene1999,18,5: | 1 |
| 14 | Canonical piece-wise-linear represen- tation 显示文摘 | CHUA I O DENG A C | 1988 | IEEETransonCAS1988,35,: | 1 |
| 15 | Processing the azimuth-variant bistatic sat data by using monosta- tie imaging algorithms based on two-dimensional prin- ciple of stationary phase显示文摘 | WANG R DENG Y LOFFELD O | 2011 | IEEE Trans Geosci Re- mote Sens2011,49,10: | 1 |
| 16 | A canonical piecewise linear representation 显示文摘 | Chua L O Deng Anchang | 1988 | IEEE Trans Circuits Syst1988,35,1: | 1 |
| 17 | The protein kinase PKR:a molecular clock that sequentially activates survival and death programs显示文摘 | Donze O Deng J Curran J | 2004 | EMBO J2004,23,3: | 1 |
| 18 | Telomerase reverse transcriptase gene is a direct target of c-myc but is not functionally equivalent in cellular transformation 显示文摘 | Greenberg R A O'Hagan R C Deng H | 1999 | Oncogene1999,18,5: | 1 |
| 19 | The protein kinase PKR:a molecular clock that sequentially activates survival and death programs显示文摘 | Donze O Deng J Curran J | 2004 | EMBO J2004,23,3: | 1 |
| 20 | The inhibitory effects of silver nanoparticles, silver ions and silver chloride colloids on microbial growth 显示文摘 | CHOI O DENG K K KIM N | 2008 | Water Research2008,42,: | 1 |