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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。 | Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao | 2015 | Nano Research2015，8，8： | 11 |
| 3 | Rumen microbiome structure and metabolites activity in dairy cows with clinical and subclinical mastitis显示文摘Background:Due to the high prevalence and complex etiology,bovine mastitis(BM)is one of the most important diseases to compromise dairy cow health and milk quality.The shift in milk compositions has been widely investigated during mastitis,but recent studies suggested that gastrointestinal microorganism also has a crucial effect on the inflammation of other peripheral tissues and organs,including the mammary gland.However,research focused on the variation of rumen inner-environment during mastitis is still limited.Therefore,the ruminal microbial profiles,metabolites,and milk compositions in cows with different udder health conditions were compared in the present study.Furthermore,the correlations between udder health status and ruminal conditions were investigated.Based on the somatic cell counts(SCC),California mastitis test(CMT)parameters and clinical symptoms of mastitis,60 lactating Holstein dairy cows with similar body conditions(excepted for the udder health condition)were randomly divided into 3 groups(n=20 per group)including the healthy(H)group,the subclinical mastitis(SM)group and the clinical mastitis(CM)group.Lactation performance and rumen fermentation parameters were recorded.And rumen microbiota and metabolites were also analyzed via 16S rRNA amplicon sequencing and untargeted metabolomics,respectively.Results:As the degree of mastitis increased,rumen lactic acid(LA)(P<0.01),acetate,propionate,butyrate,valerate(P<0.001),and total volatile fatty acids(TVFAs)(P<0.01)concentrations were significantly decreased.In the rumen of CM cows,the significantly increased bacteria related to intestinal and oral inflammation,such as Lachnospiraceae(FDR-adjusted P=0.039),Moraxella(FDR-adjusted P=0.011)and Neisseriaceae(FDR-adjusted P=0.036),etc.,were accompanied by a significant increase in 12-oxo-20-dihydroxy-leukotriene B4(FDR-adjusted P=5.97×10^(−9))and 10beta-hydroxy-6beta-isobutyrylfuranoeremophilane(FDR-adjusted P=3.88×10^(−10)).Meanwhile,in the rumen of SM cows,the Ruminiclostridium_9(FDR-adjusted P=0.042)and Enterorhabdus(FDR-adjusted P=0.043)were increased along with increasing methenamine(FDR-adjusted P=6.95×10^(−6)),5-hydroxymethyl-2-furancarboxaldehyde(5-HMF)(FDR-adjusted P=2.02×10^(−6))and 6-methoxymellein(FDR-adjusted P=2.57×10^(−5)).The short-chain fatty acids(SCFAs)-producing bacteria and probiotics in rumen,including Prevoterotoella_1(FDRadjusted P=0.045)and Bifidobacterium(FDR-adjusted P=0.035),etc.,were significantly reduced,with decreasing 2-phenylbutyric acid(2-PBA)(FDR-adjusted P=4.37×10^(−6)).Conclusion:The results indicated that there was a significant shift in the ruminal microflora and metabolites associated with inflammation and immune responses during CM.Moreover,in the rumen of cows affected by SM,the relative abundance of several opportunistic pathogens and the level of metabolites which could produce antibacterial compounds or had a competitive inhibitory effect were all increased. | Yue Wang Xuemei Nan Yiguang Zhao Linshu Jiang Mengling Wang Hui Wang Fan Zhang Fuguang Xue Dengke Hua Jun Liu Junhu Yao Benhai Xiong | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 4 | Functional groups to modify g-C3N4 for improved photocatalytic activity of hydrogen evolution from water splitting显示文摘Rational modification by functional groups was regarded as one of efficient methods to improve the photocatalytic performance of graphitic carbon nitride(g-C3 N4).Herein,g-C3 N4 with yellow(Y-GCN)and brown(C-GCN)were prepared by using the fresh urea and the urea kept for five years,respectively,for the first time.Experimental results show that the H2 production rate of the C-GCN is 39.06μmol/h,which is about 5 times of the Y-GCN.Meantime,in terms of apparent quantum efficiency(AQ.E)at 420 nm,C-GCN has a value of 6.3%and nearly 7.3 times higher than that of Y-GCN(0.86%).The results of XRD,IR,DRS,and NMR show,different from Y-GCN,a new kind of functional group of—N=CH—was firstly in-situ introduced into the C-GCN,resulting in good visible light absorption,and then markedly improving the photocatalytic performance.DFT calculation also confirms the effect of the—N=CH—group band structure of g-C3N4.Furthermore,XPS results demonstrate that the existence of—N=CH—groups in C-GCN results in tight interaction between C-GCN and Pt nanoparticles,and then improves the charge separation and photocatalytic performance.The present work demonstrates a good example of'defect engineering'to modify the intrinsic molecular structure of g-C3N4 and provides a new avenue to enhance the photocatalytic activity of g-C3N4 via facile and environmental-friendly method. | Fan Yu Laichun Wang Qiuju Xing Dengke Wang Xunheng Jiang Guangchao Li Anmin Zheng Fanrong Ai Jian-Ping Zou | 2020 | Chinese Chemical Letters2020，31，6： | 1 |
| 5 | Study on formation mechanism by monitoring the morphology and structure evolu- tion of nearly monodispersed Fe3O4 submicroparticles with controlled particle sizes 显示文摘 | FAN Ting PAN Dengke ZHANG Hui | 2011 | Ind Eng Chem Res2011，50，： | 1 |
| 6 | Dietary supplementation with inulin improves lactation performance and serum lipids by regulating the rumen microbiome and metabolome in dairy cows显示文摘This study investigated the effects of inulin on rumen fermentation parameters,ruminal microbiome and metabolites,as well as lactation performance and serum indexes in dairy cows.Sixteen Holstein dairy cows with similar body conditions were randomly divided into 2 groups(n=8 per group),with inulin addition at 0 and 200 g/d percow.The experiment lasted for 6 weeks,including a 1-week adaptation period and a 5-week treatment period.At the end of the experimental period,the milk,serum and rumen fluid were sampled and analyzed.The microbiome and metabolome in the rumen fluid were analyzed via 16 S rRNA sequencing and untargeted metabolomics,respectively.The results showed that supplementation with inulin(200 g/d per cow)increased the milk yield(P=0.001),milk protein(P=0.032),lacto se rate(P=0.004)and proportion of saturated fatty acids(SFA)in milk(P<0.001),but decreased the proportion of unsaturated fatty acids(USFA)(P=0.041).Rumen pH(P=0.040)and the concentration of NH3-N(P=0.024)were decreased;however,acetate(P<0.001),propionate(P=0.003),butyrate(P<0.001)and lactic acid(LA)(P=0.043)were increased.The total cholesterol(TC)(P=0.008)and triglycerides(TG)(P=0.01)in serum were also reduced.Additionally,inulin addition elevated the relative abundance of several beneficial symbiotic and short-chain fatty acid(SCFA)-producing bacteria,such as Muribaculaceae(false discovery rate[FDR]-adjusted P<0.01),Acetitomaculum(FDR-adjusted P=0.043),and Bu tyrivibrio(FDR-adjusted P=0.036),while elevating the levels of L-lysine(FDR-adjusted P=4.24×10^(-3)),L-proline(FDR-adjusted P=0.0158),and L-phenylalanine(FDRadj usted P=0.027).In contrast,several pathogens and ruminal bacteria abu ndant in high-fat diets,such as Escherichia-Sh igella(FD R-adj usted P=0.022),Erysipelo trichaceaeUCG-004(FD R-adjusted P<0.01)and RF39(FDR-adjusted P=0.042)were decreased along with the reduction of lysophosphatidylcholine(LysoPC)(18:1(9 Z))(FDR-adjusted P=1.03×10^(-3)),LysoPC(16:0)(FDR-adjusted P=0.0108),LysoPC(18:2(9 Z,12 Z))(FDRadjusted P=1.65×10^(-3))and 8-methylnonenoate.In conclusion,dietary inulin supplementation could increase the relative abundance of commensal microbiota and SCFA-producing bacteria,upregulate amino acidmetabolism and downregulate lipid metabolism in the rumen of dairy cows,which might further improve lactation performance and the level of serum lipids. | Yue Wang Xuemei Nan Yiguang Zhao Linshu Jiang Hui Wang Dengke Hua Fan Zhang Yapin Wang Jun Liu Junhu Yao Benhai Xiong | 2021 | Animal Nutrition2021，，4： | 1 |
| 7 | Smooth support vector machine based on circular tangent function显示文摘Support vector machines(SVMs) have been intensively applied in the domains of speech recognition, text categorization, and faults detection. However, the practical application of SVMs is limited by the non-smooth feature of objective function. To overcome this problem, a novel smooth function based on the geometry of circle tangent is constructed. It smoothes the non-differentiable term of unconstrained SVM, and also proposes a circle tangent smooth SVM(CTSSVM). Compared with other smooth approaching functions, its smooth precision had an obvious improvement. Theoretical analysis proved the global convergence of CTSSVM. Numerical experiments and comparisons showed CTSSVM had better classification and learning efficiency than competitive baselines. | Zhang Jie Fan Xuhui Ban Dengke | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，1： | 1 |
| 8 | Template-based knowledge reuse method for generating high-speed railway virtual construction scenes显示文摘Virtual construction has become an important approach to the high-quality development of high-speed railways,but existing methods have problems such as low efficiency in generating virtual construction scenes and the inability to reuse construction knowledge.To support the rapid visual representation of multiple types of construction processes and construction methods,a template-based knowledge reuse method is proposed.The method includes using a component-based modeling mode to build body structure models of a high-speed railway project and generate a 3D scene;decomposing the construction process and building a construction process knowledge base;establishing joint linkage models of construction machinery and forming a construction method knowledge template;and fusing multiple types of information according to a time sequence to visualize the construction process.Based on the template-based knowledge reuse method,a prototype system was developed,and virtual construction experiments were carried out.The results show that this method achieves the reuse of construction knowledge at different levels including construction machinery level,construction method level,and work site level.Compared with animation software for virtual construction,this method improves the production efficiency by 87%.Moreover,this method can provide a multilevel knowledge reuse scheme for diversified virtual construction. | Heng Zhang Wen Zhao Zujie Han Jun Zhu Qing Zhu Xinwen Ning Dengke Fan Hua Wang Fengpin Jia Wei Fang Bin Yang Weilian Li | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 9 | Research on the pressure variation law and enhancing CBM extraction application effect of CO_(2) phase transition jet coal seam fracturing technology显示文摘Due to the limited permeability and high methane content of the majority of China’s coal seams,significant coal mining gas disasters frequently occur.There is an urgent need to artificially improve the permeability of coalbed methane(CBM)reservoirs,enhance the recovery efficiency of CBM and prevent mine gas accidents.As a novel coal rock fracture technology,the CO_(2) phase transition jet(CPTJ)has been widely used due to its advantages of safety and high fragmentation efficiency.In this study,to ascertain the effects of the pressure of CPTJ fracturing,the influence of its jet pressure on cracked coal rock was revealed,and its effect on CBM extraction was clarified.In this research,the law of CPTJ pressure decay with time was investigated using experimental and theoretical methods.Based on the results,the displacement and discrete fracture network law of CPTJ fracturing coal rock under different jet pressure conditions were studied using particle flow code numerical simulation.Finally,field experiments were conducted at the Shamushu coal mine to assess the efficiency of CPTJ in enhancing CBM drainage.The results showed that the pressure of the CPTJ decreased exponentially with time and significantly influenced the number and expansion size of cracks that broke coal rock but not their direction of development.CPTJ technology can effectively increase the number of connected microscopic pores and fractures in CBM reservoirs,strongly increase the CBM drainage flow rate by between 5.2 and 9.8 times,and significantly reduce the CBM drainage decay coefficient by between 73.58%and 88.24%. | Xin BAI Zhuoli ZHOU Guicheng HE Dongming ZHANG Han YANG Zenrui FAN Dengke WANG | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
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